<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30733

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMPPIRSEKRMQKRISEQKISARRALRDAAQYWSKFIARCILQRLERERFNDFIRLVHSQHPLPSILVAELFLRPQPDNDVSPDPRIPPYIQALSQHGYVDAPSILRALYKYSSLHAQLNPVAQLGAMDAMDDEKGREDGASGKKPMRRWRSSSWLEEVMFYHVIKTMVEGTAFRDTRAALQLCHVMSQWMELFTSVSTSFAADVMGDVHQNTQHRDDLDVARAAFIPLLLRLVETPLLVKAIGKPFAKSIRKYFSKSLARFVQTLQPTPFVDRLEMFRTDTLAKLDPADKKKQAAANAAMDELLDTTVGLDSFVIPDMPISNTRAALYIYLNASGQTQSGVIDLILASFDVLANAVFRSEASKDAHLLKTFLISKLPLIVCQLCTGFDINSTEFCITEALNRVDTTIFPTTSLMFDETRSNNPYTDSVREEFCTACALHGLVQRDHVERILGETSMSYESSLEKHSKDRLVQDCFADAEKMQGLIRDVEKIDGNVGAVAHALVDIMRQLCHNKDTVSLHLLCSQLAQKPHTLDILLLFEKVSAILQPLCQLLDNWHYEEDQGEYQPIYEEFGSILLLILAFSYRYNLTAVDMGIMSPDSSVAKILTSAHVSRERDDLSDQEKGHVTGWIKGLFSSDSGGLGDDLMSSCTPHDFHSLVATIFQNIVVAYAHGYLKDEALKGGIEYLVDTFLLPSLVPALRFLADYLWVEQKEQKAIIRILQLILLPSSISGEASAMLSSVRNLVAAPLDHSLRTYQRQDPKNQNIEPLLMALRDNLPLSRRTGGADHCELDSWTISSSTGMAGALRHTVQGLVQWAIHPAANTIAAPYTHRQLMAMTRVAGAKRTLCLLVDEVRTQSEAGSASIVYDVVGAMICAPDVTNEPPPAKGMLGASGHAPVTTGRPLTLRQMLALWAEQARTLQKKDATFADIVVRLHRRVEAHMVMPPPQTMLEAPGIQLDLTIGGSGLGDVDAMAAAGGGVDSVGLDMGMGAPGSAGGMDTTGDGDLFGGLDTSMDMFGWDSMDLTGT
Length1025
PositionTail
OrganismClaviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Claviceps.
Aromaticity0.07
Grand average of hydropathy-0.092
Instability index41.46
Isoelectric point5.69
Molecular weight113201.55
Publications
PubMed=23468653

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30733
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.61|      22|      22|     966|     987|       1
---------------------------------------------------------------------------
  966-  987 (39.65/24.51)	GDVDAMAAAGGGVDSVGLDMGM
  991- 1012 (40.96/25.58)	GSAGGMDTTGDGDLFGGLDTSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.75|      18|      18|     508|     525|       4
---------------------------------------------------------------------------
  508-  525 (34.22/23.73)	QLCHNKD......TVS..LHLLCSQL
  527-  552 (22.53/13.08)	QKPHTLDilllfeKVSaiLQPLCQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     180.81|      41|     144|     456|     496|       5
---------------------------------------------------------------------------
  428-  452 (19.55/ 7.65)	.....................VRE.EFCT..ACA..LHGLVqRDhVERI....LG
  456-  496 (72.47/49.11)	MSYESSLEK.....H.SKDRLVQD.CFAD..AEK..MQGLI.RD.VEKID.GNVG
  595-  641 (38.20/22.26)	MSPDSSVAKiltsaHvSRER....dDLSD..QEKghVTGWI.KG.LFSSDsGGLG
  645-  682 (50.58/31.96)	MSSCTPHDF.....H.S...LVAT.IFQNivVAY..AHGYL.KD..EALK.GGI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.57|      24|      34|     152|     177|       6
---------------------------------------------------------------------------
  152-  177 (39.53/31.26)	SSWLEevMFYHVIKTM...VEGTAFRDTR
  187-  213 (39.04/24.51)	SQWME..LFTSVSTSFaadVMGDVHQNTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.84|      17|      21|     245|     261|       7
---------------------------------------------------------------------------
  245-  261 (28.78/18.12)	PFAKSIRKYFSKSLARF
  269-  285 (28.06/17.50)	PFVDRLEMFRTDTLAKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30733 with Med5 domain of Kingdom Fungi
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