<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30732

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFAQYDTNTLVLNNISSISFRVYEPTAEKSQFFGLIAVEIESRLRERGHIVYYDASRRCIWTFKVQRKAGSSNQGSEDLSQSLGSHIHLLASGEEGIFDPGSLQKPRVVPQGGLSSTSSAPSALAVDQSQRQKPGSSSQIEVSHLQEQDQTITVVPTVDSKGAQSEPTSSKVIYENFIIATVLTISTAFSKRSGSIPLDYRTLLLSEQVLGNAGLGYNGEQKPTIGTFKAYMTSTGNLVLSLGFSVCRGMLLCNETLNLGPASLGNRILAAPFGMIAGNQLPSPVEVGTSSMAHTPNTQVLSFRGAPDVQDSPWRQTCSKLLQFRGIARSRLADCPWMNVLVSNSKFYDTKPDHKRQQLANSTVMFPWPGALCFRKKPIDALSTGRTGDSVLSRQEEHRDPLGDAQAWFKSFCEREEQIAKRKQERAAASKEAAALASRQSRSIGQSPLAIRRPSTTAAGSMYPTPPDVLQSLNGVVPALDGTSSSPGNSLATVALPINDHNSSDYAATIAPHDFGQDQEPKREGVDSHLLGNPEHIYGDMGGDMFGDNDITEADFNFFDEDPGGVDLDTAMGSMSDEAIGVNTTSNLDEGNSSTTEFRKQDILLENETEAFTKPELRHAISSQKGARRGRGSRRVSFKRDLSPFDPQTVFKKVRPSFRAADETSHANTDGTRRRKAFEKIEFDPMLPLINKKYEKGGQFDYTKIASSEKPKLTLGTVPQTNYLKRHRRPKRRSKHHNPDGLQCSSFLASLTRTGPLFSGSSPIKSNSQNSDGELSSCDSEQDDSSSDDESMSPARFRVKFVSLDDDAASHVTSLKEADALEEPDHQLAVELPRLYKPETPEIPLSVLFADPEPLSLEISLGDEDLIQVAQILTEQAATGTLHLGISVAADAKSSSVTERNHQGLLVEARSSLQLLREVVSSYLPGTASIHLKGFLDTRDVPLQGQPTRPQPRQVPGREANAPEQQKRPSNLYQIPSPHLEVRRTEAKLSVLPSAITFWELLGLAPSSGSKDIASVCVFPGCKGMSDSVKTFLSRVKSVYEVLRLGSVDNLALSPDMDDGILPYEVDQTSASPATTATGHGSALASSMETLRDALSNLAVSDTNVVVFFVYVPSNPGSIVEACVAFQQFFDSYQKELLAKKEPVSNEIVLQLVSADILSSPTSVVVTPSQELVKLCLETYDRCTLFGGPMPAPAIRLEQALPRIIEFKLVHTPSASLAKENSCIHIAYAQSVDDRWITAAWTDDRGNQQATASYCMGRKGRPLSRLRNEVAHEIWDSTLDLVAACKVHWRVIITKCGPMDRDEIEFWIDLARTEIKASVTLILMTVDTNPSLQLIPPAVKLPQAATAPLNTNLGSAAQPNNNLVVSPDQSTATPGVSETGTADTPDMDVILLDVTDQTWGAVLGHRLNSSASITDLQPALISGYLIKRTGPRVEDPLTAMEINLVHTDASPRSYEPLLREMLSHFRGLATLSRARGVVARDTDVRPLHIAAAEKGVRAMYLLM
Length1504
PositionKinase
OrganismClaviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Claviceps.
Aromaticity0.06
Grand average of hydropathy-0.341
Instability index51.08
Isoelectric point5.73
Molecular weight163782.50
Publications
PubMed=23468653

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30732
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     553.51|     188|     310|     546|     855|       1
---------------------------------------------------------------------------
  446-  676 (277.04/310.83)	GQSPlaIRRPSTTAAGSMypTPPDVLQslngvvpaldGTSSSPGNSLAT.......VAL..PINDHNSS..DYAATIAP.HDFGQD....QEPKREGVD.SHLLGNPEHiygdmggdmfgdnditeaDFNFFDEDPGGV.DLDTAMGSMSDEAIGVNTTSnlDEGNSSTTEFRKQDILLENETEAftkPELRHAISSQKGarrgrGSRRVSFKRDLSPFDPQTVFKKVRPSFRAAdETSHANTDGTRRR
  761-  969 (276.48/182.87)	GSSP..IKSNSQNSDGEL..SSCDSEQ..........DDSSSDDESMSParfrvkfVSLddDAASHVTSlkEADALEEPdHQLAVElprlYKPETPEIPlSVLFADPEP...............lslEISLGDEDLIQVaQILTEQAATGTLHLGISVAA..DAKSSSVTERNHQGLLVEARSSL...QLLREVVSSYLP.....GTASIHLKGFLDTRDVPLQGQPTRPQPRQV.PGREANAPEQQKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.25|      32|     310|    1046|    1090|       2
---------------------------------------------------------------------------
 1046- 1090 (42.36/45.81)	LGSV....DNLALSPDmddgilpyevdQTSASPATTATghGSALASSME
 1354- 1389 (52.90/26.81)	LGSAaqpnNNLVVSPD...........QSTATPGVSET..GTADTPDMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.85|      19|      20|     296|     315|       3
---------------------------------------------------------------------------
  296-  315 (32.52/27.02)	TpNTQVLSFRGA..PDVQDSPW
  318-  338 (31.33/19.63)	T.CSKLLQFRGIarSRLADCPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.59|      21|      24|     236|     256|       5
---------------------------------------------------------------------------
  236-  256 (39.22/22.56)	TGNL.VLSLG...FSVCRGMLLCNE
  257-  281 (28.38/14.38)	TLNLgPASLGnriLAAPFGMIAGNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.87|      17|      25|     100|     116|       6
---------------------------------------------------------------------------
  100-  116 (30.71/17.95)	DPGSLQKPRVVPQGGLS
  128-  144 (29.15/16.63)	DQSQRQKPGSSSQIEVS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30732 with Med13 domain of Kingdom Fungi
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