<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30701

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMTTTPMMPPMGNANFDGGAPALPPQPGTDMTGICFRDQLWLNTYPLDRNLVFDYFALSPFYDWTCNNEQLRSRSIHPLDISQLSKMTGSEYMLSEVMERHLFVIRKQKRDGPEKVTPMLTYYILDGSIYQAPQLCNVFAGRLGRGLYHISKAFSFASSKLEKTGYVASENERSASESKAAKETIDFKELKRVDHILASLQRKLPPVPPPPPFPEGYVPPSTAESSENQQAETLLPPVDPIIDQGPSKRMKV
Length251
PositionHead
OrganismSolanum tuberosum (Potato)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Solaneae> Solanum.
Aromaticity0.09
Grand average of hydropathy-0.465
Instability index63.04
Isoelectric point6.44
Molecular weight28173.92
Publications
PubMed=21743474

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.07|      13|      33|      34|      47|       3
---------------------------------------------------------------------------
   34-   47 (23.67/18.10)	CFrDQLWLNTY................PLD
   51-   79 (15.40/ 6.25)	VF.DYFALSPFydwtcnneqlrsrsihPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      26.63|      11|      55|     168|     191|       5
---------------------------------------------------------------------------
  150-  162 (13.71/12.40)	SKA....FSFasSKLEK
  177-  191 (12.92/ 8.16)	SKAaketIDF..KELKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30701 with Med6 domain of Kingdom Viridiplantae
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