<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30534

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMDPSPQNSSSTAGNGGLPSTGAAAASSPAPNPTSAGTIGSAADPAEEAKQNLTQVINSVDKTLGLLHQLYLTVSSFSVASQLPLLQRLNALVAELDAMQKMADKCNIQVPMEVVNLIDDGKNPDEFTRDVINSCIAKNQITKGKTDAFKSLRKHLLEELDQAFPDEVETYREIRASSAAESKRLAQSQSALPNGDVKVKQEH
Length202
PositionMiddle
OrganismMusa acuminata subsp. malaccensis (Wild banana) (Musa malaccensis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Zingiberales> Musaceae> Musa.
Aromaticity0.03
Grand average of hydropathy-0.412
Instability index42.26
Isoelectric point5.09
Molecular weight21499.83
Publications
PubMed=22801500

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364146
GO - Cellular Component
chromatin	GO:0000785	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30534
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.78|      12|      16|      58|      69|       1
---------------------------------------------------------------------------
   58-   69 (20.60/16.53)	SVDKTLGLLHQL
   77-   88 (20.19/16.05)	SVASQLPLLQRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.08|       9|      15|      21|      31|       2
---------------------------------------------------------------------------
   21-   31 (12.45/ 9.62)	GAAAasSPAPN
   39-   47 (16.63/ 6.80)	GSAA..DPAEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.84|      11|      20|     115|     126|       3
---------------------------------------------------------------------------
  115-  126 (16.46/14.63)	NLIDDGKNpDEF
  138-  148 (20.37/11.93)	NQITKGKT.DAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.35|      17|      26|     156|     172|       4
---------------------------------------------------------------------------
  156-  172 (28.62/18.37)	LEELDQAFPD.EVETYRE
  184-  201 (22.73/13.31)	LAQSQSALPNgDVKVKQE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30534 with Med10 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDPSPQNSSSTAGNGGLPSTGAAAASSPAPNPTSAGTIGSAADPAEE
1
47










Molecular Recognition Features






MoRF SequenceStartStop




1) ETYREIRA
2) LRKHLL
168
151
175
156