<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30502

Description Mediator complex subunit 12-like (Fragment)
SequenceQQQQQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSPQLPQYPGLQQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYSSRAYPAAHSSPALMERLRQLQQQPGGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGAIDAVLTPAHPNLPSVPLAQDPMRPRQQQVRQQQRLLQVRGREMQQPQQAPQPQQPSQPQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPCAHPSHF
Length261
PositionKinase
OrganismRattus norvegicus (Rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae> Murinae> Rattus.
Aromaticity0.04
Grand average of hydropathy-0.951
Instability index94.98
Isoelectric point11.25
Molecular weight28982.20
Publications
PubMed=15057822

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central
transcription factor binding	GO:0008134	ISO:RGD

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30502
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.03|      30|      32|      89|     120|       1
---------------------------------------------------------------------------
   54-   84 (41.71/ 8.33)	PQGYTMYGTQMPLQQaAQQQPGGVV..LSPSYS
   89-  120 (51.33/16.54)	PAAHSSPALMERLRQ.LQQQPGGYVqqQASPYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.25|      35|     221|       1|      37|       2
---------------------------------------------------------------------------
    1-   37 (60.64/16.26)	QQQQQQQRLLRQAQTRPFQQGQPgdQAALFTAQA.RPS
  191-  226 (55.52/11.29)	QAPQPQQPSQPQSQALGLQAMQP..QQPLFPRQGlQQT
  227-  259 (56.09/11.49)	QQQQQTAALVRQLQ.KQLSSNQP..QQGV.TPCA.HPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30502 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQQRLLRQAQTRPFQQGQPGDQAALFTAQARPSPQLPQYPGLQQQAQTMPQGYTMYGTQMPLQQAAQQQPGGVVLSPSYSSRAYPAAHSSPALMERLRQLQQQPGGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGAIDAVLTPAHPNLPSVPLAQDPMRPRQQQVRQQQRLLQVRGREMQQPQQAPQPQQPSQPQSQALGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPCAHPSHF
1
261










Molecular Recognition Features






MoRF SequenceStartStop




1) AALFTAQARPSPQLPQYPGLQQ
2) QQQQQQQRLLRQAQTRPFQQ
3) YSSRAY
27
1
83
48
20
88