<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30486

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTXGLEAGPPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHSEQLHKTGFPTVHAVVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKDFTEDVNSAFLLKLTPLLDKADQRCNCDSTNFLLQECSKQGLLSEASVSSLMAKRAADRENVPQLKSAENANIQPNPGLILRAEPTTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLRSFARKFINLNEFTTHGSEENTKPASVRALLFDISFLMLCHVAQTYGSEVILSESNTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILERMCADVLQQTATQIKFLSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYISLFPLDDIQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length957
PositionTail
OrganismTupaia chinensis (Chinese tree shrew)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Scandentia> Tupaiidae> Tupaia.
Aromaticity0.07
Grand average of hydropathy0.033
Instability index48.34
Isoelectric point6.15
Molecular weight106383.47
Publications
PubMed=23385571

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30486
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     390.65|     113|     115|     177|     291|       1
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  177-  282 (166.96/107.20)	..........EASSWTAI...........EHS.LLKLGEILANLSNPQLRSQAEQ.CGTL...IRSIPTM..LSVH.SEQlhKTGFPTVHA....................VVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACF
  283-  392 (141.71/84.97)	VGLIESPEGtEELKWTAFtflkdftedvnSAF.LLKLTP.........LLDKADQrCNC.....DSTNFL..LQEC.SKQ....GLLSEAS....................VSSLMAKRAADRENVP...QLKSAENANIQPNPGLILRAEPTTM
  394-  497 (81.98/46.00)	ADHSKSPEG.......................lLGVLGHMLSGKSLDLLLAAAAA.TGKLrsfARKFINLneFTTHgSEE..NTKPASVRAllfdisflmlchvaqtygseVILSESN...TGAEVPFFETWM......................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.58|      57|     117|     584|     644|       4
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  584-  644 (87.03/67.07)	LAVCAVAWLVAHV..RMLGLDEREKSLQMIrQLagpLYSENTLQFYNERVVIMSSILERMCAD
  704-  762 (94.56/59.76)	LHMGGVYWFCNNLikELLKETRKEHTLRAV.EL...LYSIFCLDMQQVTLVLLGHILPGLLTD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30486 with Med24 domain of Kingdom Metazoa
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