<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30484

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMRPAAASMMDLAYVCEWERWPKTTHCPSVPLACAWSCRNLIAFTTDLRSDDQDLTRLIHILDTEHPWDVHSFPSEHSEAITCLEWDQSGSRLLSADGNGQIKCWSMADHLANRWESLVGSSVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSDKCRIDTEILPSLFLRCTADPSRKDRLPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNVFQQICPVGSCVVPGLCPSGGLGQDAPVQSPAPALRPPPGHLLPAGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAIFHSSVASRPVDEPAVKRPRTAGPAVHFKAMQLSWASLALVGIDNHGKLSMLRISPSMGHPLDVHLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVERLHEEYTRQNAALQQVLSTRILAMKASLCKLSPCTVVRVCDYHTKLFLTAVSSTLKSLLRPHFLNTPDKSPGDRLTEICAKVTDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGAPLRPGHSFLRDGASLGMLRELMVVTRIWGLLKPSCLPVYAATSDTQDSMSLLFRLLTKLWICCRDDGPTSEPDEALVDECCLLPSQLLVPTLDWLPASDGLVSRLQPKQPLRLCFGRAPPLQLDGLARTPGQPKIDHLRRLHLGAHPTEECKSCTR
Length825
PositionTail
OrganismTupaia chinensis (Chinese tree shrew)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Scandentia> Tupaiidae> Tupaia.
Aromaticity0.06
Grand average of hydropathy0.050
Instability index50.78
Isoelectric point7.11
Molecular weight90545.06
Publications
PubMed=23385571

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30484
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.37|      19|      37|     477|     497|       1
---------------------------------------------------------------------------
  477-  497 (31.01/26.24)	GIDNHGKLsmLRISPSMGHPL
  517-  535 (38.36/25.08)	GYDWWDIL..LHVQPGMVQSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.01|      29|      37|     753|     783|       3
---------------------------------------------------------------------------
  753-  783 (46.53/30.83)	PSQL..LVPTlDWLPASDGLvSRLQ.PKQPLRLC
  789-  820 (46.48/23.16)	PLQLdgLART.PGQPKIDHL.RRLHlGAHPTEEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.34|      41|     312|     351|     399|       5
---------------------------------------------------------------------------
  351-  399 (61.20/54.05)	LRppPGH.LLPAGDKQPMILKWRILSatndldRVSAVALPK.LPISLTNTD
  671-  713 (64.14/37.13)	LR..PGHsFLRDGASLGMLRELMVVT......RIWGLLKPScLPVYAATSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     183.54|      44|      44|      49|      92|       6
---------------------------------------------------------------------------
   11-   47 (44.59/26.07)	.........LAYVCE.WERwPKTTHC.PSvPLACAWSCRNLIAFTTDL
   49-   92 (76.82/50.96)	S.DDQDLTRLIHILD.TEH.PWDVHSFPS.EHSEAITCLEWDQSGSRL
   94-  139 (62.13/39.62)	SaDGNGQIKCWSMADhLAN.RWESLVGSS.VEGDPIVALSWLHNGVKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.16|      24|      37|     163|     186|       8
---------------------------------------------------------------------------
  163-  186 (42.17/29.08)	SLTLFGGKPMEGWIAVTVSGLVTV
  201-  224 (40.99/28.05)	SLCRLRGRVALADIAFTGGGNIVV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30484 with Med16 domain of Kingdom Metazoa
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