<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30482

Description CMGC/CDK/CDK8 protein kinase
SequenceMPPTQSHDVMRTYRARKDEARIAVNSKYHILGFISSGTYGRVYKAQAKDTNGTIVVTGPSAGVYAIKKFKPDKEGEVVTYTGISQSACREIALTREMRHENVIVLREVMLEDKSIFMVFEYQIIHHHSQTLHQAILLPVLKSFMYQLLNGLLYLHNSHIMHRDLKPANILVTAARPMPATSTGSAVPITQGGVVKIGDLGLARLCRSPLQPLLSGDKVVVTIWYRAPELLLGARHYTKAIDCWAVGCIFAELLALRPIFKGEEAKLDAKKNVPFQRDQLTKIFDVLGTPTEQNWPGLTSMPEYKNFITCDRQENKLSQWYRQRSRNLDCGYDLMCQLFEYDPARRLDARGALSHWWFQEEPVPTVNAFAHLPDGVSYPLRRVTQDEAPLTNAPPALTAGHVADSRPGSSSYLISRMTGAAGQVPGHQPPRKKSRME
Length436
PositionKinase
OrganismThanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.08
Grand average of hydropathy-0.297
Instability index44.64
Isoelectric point9.28
Molecular weight48963.85
Publications
PubMed=23361014

Function

Annotated function 
GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30482
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.50|      66|      85|     173|     247|       1
---------------------------------------------------------------------------
  173-  247 (110.30/96.46)	AARPM.....PATSTGSAVPITQGGVVKI.GDLGLARLCRSPLQPLLSGDKVVVTI.........WYRAPelllgarhyTKAIDC.WAVGC
  254-  335 (100.20/69.74)	ALRPIfkgeeAKLDAKKNVPFQRDQLTKIfDVLGTPTEQNWPGLTSMPEYKNFITCdrqenklsqWYRQR.........SRNLDCgYDLMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.67|      15|      27|     119|     133|       2
---------------------------------------------------------------------------
  119-  133 (29.63/20.03)	FEYQIIH.....HHSQTLHQ
  143-  162 (24.03/15.06)	FMYQLLNgllylHNSHIMHR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30482 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) GHQPPRKKSRM
2) YLISRMTG
425
411
435
418