<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30481

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTENYDPNSVKLSLEPPYRDDNGKPIPDLRDITQDGQLVFEEWVQLFLVIFLWSTNDLFPRKQSPSAALGPQLKRLHELITSRKREFRSITETRVLANGAGIVDSESSPGAVNKTEEPQDMIVDEDGQAEPTGDDQASLSSALNPESLNQLRKDMTQRLEEAQYSMNAALDMLNCLLAINNLSANVATSTSTNPTAGIAGFGSVTTTQTAPAPLTLAPSIIAPTPPQASVAVMNTQIGITTRDAGIRKAAGILRHAALSTAEEIERAGRSGTGGVAQGRHDTGYWATALRLRQACWALLPAALPPGSGSKGSNRTSKDILLGFALEGSPPPYRRLAHGIIPTNNTQQKNQANDDKPPPLLLFPQLQNRRLRVSLRINGKKYSCPIDSQTGSPAPPGTRTGSTGQTLNNLMRDAQQEVIEHEIFQEASLQITTQADNLNRVTQILAQARFAGILISQLSVAMDEEDLDEEVTVTNPSEADVVTCMLIRQILVVLLARAHRGALLDGMSASSTTPAPNAPAAIRKQVPILGPIVSLLRYRTMVQRVDLELKKILSGMGRAGIDATLTMKRVNEPGHIFVESLSRFVDTQGEAFQSTLHHRLDQSLALSGEALLRIEDKHLIQVTFQSPTSLKLHVVQSQITVHDHGQLGSFLRTDVAGRIVQFVQEVGKEFLKEPNKLDRISGEYDRSWFVDPIGAYCIGRCRFQLEIQENGRIRCEATVESQSKQTVSQFEHAPRGTSLKSWVLSVMAGASRLPLFDISLGVLDVLNVGAKVCACLGTTGTLIKENSSLYVASKVLGEVEVISKLTAAMDGQCICKEGHQDCNGKCVLVSQSCSSQGPKTQYTVHQISGGRNKRGGRGTPNWARRALSSAHCPIGTEMCGVFGRPDAWECLNVEEDLESCGGCAYPFFPGQKPGVDCSAIPGVEDVACLMGLCQISKCAANLVISVDGRACEPNEHAKSRDFISTGRANKVSHAEHYGQPTMLVSATGAEIMIATGHSPALREQTPLLNA
Length1009
PositionHead
OrganismThanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.05
Grand average of hydropathy-0.237
Instability index41.80
Isoelectric point6.27
Molecular weight109051.67
Publications
PubMed=23361014

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30481
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     268.26|      85|     306|     128|     223|       1
---------------------------------------------------------------------------
  128-  223 (128.09/102.40)	QAEPTGDDQASLSSALNPESLNqlrkdmtqrlEEAQYSMNAALDMLNCLLAINNLSANVATSTSTNPTAGIAGfGSVTTTQTAPAPLTLAPSIIAP
  446-  530 (140.17/88.24)	QARFAGILISQLSVAMDEEDLD..........EEVTVTNPSEADVVTCMLIRQILVVLLARAHRGALLDGMSA.SSTTPAPNAPAAIRKQVPILGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.26|      12|     313|      16|      27|       2
---------------------------------------------------------------------------
   16-   27 (26.15/17.19)	PPYRDDNGKPIP
  330-  341 (25.11/16.19)	PPYRRLAHGIIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.75|      27|      29|     567|     593|       3
---------------------------------------------------------------------------
  567-  593 (46.23/32.85)	KRVNEPGHIFVESLSRFVDTQ..GEAFQS
  597-  625 (39.52/26.98)	HRLDQSLALSGEALLRIEDKHliQVTFQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.75|      21|     578|     260|     286|       9
---------------------------------------------------------------------------
  260-  286 (26.41/30.04)	TAEEIeRAGRSGTGGvaQGrhdTGYWA
  842-  862 (42.34/23.27)	TVHQI.SGGRNKRGG..RG...TPNWA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30481 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NGAGIVDSESSPGAVNKTEEPQDMIVDEDGQAEPTGDDQASLSSALNPESLNQLRKDMTQRLEEAQ
2) YRRLAHGIIPTNNTQQKNQANDDKPPPLLLF
98
332
163
362










Molecular Recognition Features






MoRF SequenceStartStop




NANANA