<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30478

Description Med6 domain-containing protein
SequenceMHVLHAQLRDPGFIYRNLSFWRMKTRRKMTIIILTTSGTRMSYFGFLTDTSFWAYSCIICISVVLRSIGRLLSEPTLTITYTMATPADDHSEKVLVYHEWLNVRNVLEYFAACQLFWDPQCNNNILRMQSQHLGTSVNLDELKWVSQRDRVCSGPCRTANLVYNSQEGEAQPDRKIPFTKLSTSILLCQTDSSVPLGRAQLTVLKCNFQSTAVNCLSDSLSLIRPYKPEFSPRTGYQWWALRHQSYFHLAFTILRNIIDDSVEEGDDSNTNQLRNQPKRQVATIPGMMAALQTTRSHMEQQYQEKQKRAEQEAAANAVASSGTAPGTRPASVAPMTPAPDAIPRPPDADASAIASASKTPAPKGQGKKKQKRKWILTGEESVLNVIYRIVYGRRKGCPVKIPI
Length403
PositionHead
OrganismThanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.08
Grand average of hydropathy-0.367
Instability index47.65
Isoelectric point9.47
Molecular weight45432.59
Publications
PubMed=23361014

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30478
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.76|       9|      30|      12|      21|       1
---------------------------------------------------------------------------
   12-   21 (15.20/13.77)	GFIyRNLSFW
   45-   53 (19.56/11.39)	GFL.TDTSFW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.89|      13|      29|     156|     171|       2
---------------------------------------------------------------------------
  156-  171 (18.40/18.78)	CRTANLVynsQEGEAQ
  188-  200 (24.48/14.38)	CQTDSSV...PLGRAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.47|      32|      63|     277|     308|       3
---------------------------------------------------------------------------
  277-  308 (55.05/32.76)	PKRQVA...TIPGMMAALQTTRSHMEQQYQEKQKR
  314-  341 (28.44/13.64)	AANAVAssgTAPGTRPA...SVAPMTPAPDA....
  343-  372 (47.98/27.69)	PRPPDA...DASAIASASKTPAP..KGQGKKKQKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30478 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSVEEGDDSNTNQLRNQPKRQVATIPGMMAALQTTRSHMEQQYQEKQKRAEQEAAANAVASSGTAPGTRPASVAPMTPAPDAIPRPPDADASAIASASKTPAPKGQGKKKQKRKWI
260
375










Molecular Recognition Features






MoRF SequenceStartStop




1) QGKKKQKRKWILT
2) VIYRIVY
365
385
377
391