<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30473

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMEQPTVNDITKAAFLSGYPAENWLAIVQQLKPHGPSNLPASEICASIFSLLEAYPLSPVLLQYLCVALDSESPHPVLPIGIYISTLIAWSQTILASPTDQTTQLLSALCAIAAPRVQKPSANLTPTLPTAQGCVSLVQHVSLTHDAILTSSALDILLAILKTVVASSPNPNLSPFLALNLVPAINDLLDAGEIVSPQLTNWLFQLSALTTADGHGHGHATSRVQPQQVTDEPPQRPELLEFTRNGPLFDVLAYQVTSVLAYPDSHLSALQTVFNSTPTPDAFFSQLYASLISVLANEPDGNTRTIICAALFGSVRHPGPPRTTCLLTHYTPSCPSSFVNSRHHRINLCKDGVQSAIHGLFTHFGALLDKCDVTAPITRVSREDSMEEDVPEDGSKGKNIRTMLVQSLQSVSLLDSNFPSLPGLTIENWPGRGIGRVFAEAGENGQDLEVSPTSAVPIQASKSWIPQSDKLELIDRAVADPETHACLCTVLHKGYTSLTTSTQHLSPATLESLANLSRLLYTHPTVLDVVGLRVPPAEFVAAGLAFLEDLEGAGVGDPQSALGQYGDVLLLLQLLVTRYEVRTQFRAYPVLQPFGSCQMFQQKSGTLKHGDRVLDASCLTSSWAVYNLSDLTEPERTLISDWVKAAFDSNSFGIDDNVLRSTNPRVLLKLSATLFTEAIRKCAAEPEGAGMEILRNGVSYFEGPLLNWTLRGVIWALANEAERHGHAAQTHLDVLQLLVLANGCPAPVIEMTRHRVLRLLASPYIPKANIDVNAMLRVLHPSNSGSGSGSTNTTAPLYASSYLNLALQASIGGTPIPNPARILGFTNSLELLRAPVQQGSDSVAHRNILIALLTLARPRFAGIKSVLSALRSLAGTMDPDFLAGVVAGSVSVWVAAPMERALAREKVKKFVNEGEKEKGLEGIVKRMVGVEGVRRVALQTTTTYILDMVSNEQKIDSVGGSPVSVSDMSLISDVESVLSLENNKRFSMISSTTFNDMENTPVPVAPIDFPGTPIEKQLPVHPDFAYEDGNIEFQKMYSGYMSFNSGNSPFSPDALTRQGRKERLQAPVASGFVRRGVVTTLVVPFVSFIRGDVFSSAVAPKFNSDTLISALRVGTRYGCPDMRNFAITQLESRFQSPPIDRIKLSDEFNIPNWAIPAFIELCQRTEPISQREARILGAERLVEVSRIREAEQRRKFIQLVDKSMGPCGVFEAGQMTDDKLRDDASEIFVIVGAFIPLIVAVTLQRTCDDTDLNNRPANPNAFTSNNRHSISDPFNLGSLHARSGDANGSRYSVVPCQIHMIAPRIITESLALFKRCGGLTRQLGDLKVAVSNGAPQGAKQFSVEDEIQRATWIRKTT
Length1356
PositionTail
OrganismThanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.06
Grand average of hydropathy-0.019
Instability index43.47
Isoelectric point5.90
Molecular weight147082.11
Publications
PubMed=23361014

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30473
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     970.22|     308|     462|     125|     448|       1
---------------------------------------------------------------------------
  127-  448 (491.08/415.90)	LPTAQGCVSLVQHV.SLTH.DAILTSSALDILLAILKTVVASSPNPNL.SPFL..ALNLVP.AIND..LLDAGEIVSPQLTNWLFQlSAL..TTADGHGHGHATSRvqPQQVTDEPPqrpeLLEFTRNGPLFdVLAYQVTSVLAYPDSHLSALQTVF..NSTPTPdaFFSQLYASLISVLANE..PDGNTRTIICAALFgSVRHPGPPRTTCLLTHYT.PSCPSSFVN.SRHHRINLCKDGVQSAIHGLFTHFGALLDKCDVTAPITR.VSREDSMEEDVPEDGSKGKNIRTMLvQSLQSVS.LLDSNFpsLPGL...T.IENW...P.GRGIGR....VFAEAGENGQDLE
  479-  568 (50.59/24.89)	..........................................................................................................................................................................................DPETHACLCTVL.....HKGYTSLTTSTQHLS.PATLESLANlSR................LLYTH.PTVLDVVGLRVPPAEfVAA.........................................GL...AfLEDL...E.GAGVGD....PQSALGQYGDVL.
  590-  920 (428.55/318.08)	LQPFGSCQMFQQKSgTLKHgDRVLDASCLTSSWAVYNLSDLTEPERTLiSDWVkaAFDSNSfGIDDnvLRSTNPRVLLKLSATLFT.EAIrkCAAEPEGAGMEILR..NGVSYFEGP....LLNWTLRGVIW.ALANEAERHGHAAQTHLDVLQLLVlaNGCPAP..VIEMTRHRVLRLLASPyiPKAN...IDVNAML.RVLHPSNSGSGSGSTNTTaPLYASSYLNlALQASIGGTPIPNPARILG.FTNSLELL.RAPVQQGSDS.VAHRNILIALLTLARPRFAGIKSVL.SALRSLAgTMDPDF..LAGVvagS.VSVWvaaPmERALARekvkKFVNEGEKEKGLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.51|      30|      47|     993|    1023|       2
---------------------------------------------------------------------------
  993- 1023 (52.38/36.36)	FNDmENTPVPVAPIDFPGTPIEKQLPVHPDF
 1042- 1071 (53.12/31.88)	FNS.GNSPFSPDALTRQGRKERLQAPVASGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.12|      12|      16|    1072|    1083|       7
---------------------------------------------------------------------------
 1072- 1083 (19.73/ 9.78)	VRRGVVTTLVVP
 1088- 1099 (20.39/10.32)	IRGDVFSSAVAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30473 with Med5 domain of Kingdom Fungi
Unable to open file!