<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30472

Description Med12 domain-containing protein
SequenceMQSNLPDNSSALRTTVPAISQQLECDAIVTNAYLNAQLLIFPHATTRGWSGEGLSVPVRARGSTLVKPYGQFTNFIIDTLHTHAAPRYRSKAIGYSLQTHCNAWGSQKFVPGTRRCTFHISAHHTWPDDLRVCNLENKHIMHHISPVPRVKLIPPARAAKRSGRKRCSEFVATGFRKECVTRPHLIPARKPRAETLTQGLLRIQPNLNLPPQKSQTLNLLLGVRDGAMQQTSVSDIHYTLWGTSMIANLGRKPPSVSVTLLRWHLGYPGFDPPRPGQPEDTLTEHYVKNGYTFVNTALGNVANDSFSAHGLIYGSLKPSRNRSALALLGDLMSAVYEVRTESSAGIPCVFQLRTACMTPRMTLNDTRRTAWLADLSNPTIPLSKLAKTVLHVAKGPDLLDMLHANNVAISRAVWYVRILGLSIKSRPNYNPAQLAIEWAGTVTTHLKKQLQEIVLPSAPRPGLPIKSTFKSTLTQADTKANVELMRAFYVEHMVDHGAMLSWLSAQVLPANIAQFYFVLRLVEEYLDDIAQHRLFAQPVIEGCLAKLVEVGCLASASTHVLHRLFLLNPDYFVCGRIWAQPSYRRLLQTSFQDRMKLVLGEHKSDAEVLDTIGTFAGVAARNDGLLFRVLPERAVVDMRATIADVQLLNSIGPGTDLSCASYFQPDGSDDQKLSVLLTWAVTPSQYGSHRPFLACSLLARRSEGTRWQEGIWRWLDESDEVRAVGIWENDKEEGLSTSAGIDDASKIMWHSRDAVALLVGELTEKGLFSYGWYMQKLIARGITDPNLARVASSHHRTLLHVLPLSSENTTMSVMRSNTLYRQGSNLQNQMVRAVCKELQPLLLELVGGMDPANEPWTSTTLTSLERYLSAGRYILMLAINDWLLATVHQSLDQWVGHSRTRTKLTEHYQRSANEQRYLFPNCTNTFVLQSPCDDILDVVIAVIERYTNIWVAMDIMNEIGEELFKKHQALHLEHKHCRSLFTLLGSLSSAGSLPESAHHQIESEVNFITQSLHPQTDGTVDPSLSSSQIKSLVNDIPLEQVVIIADDIWYKHHALESWATGIWDHVFASLCTVPQTTPDSQKSEIASRYVTFLVKLSSHSISGLDSYMREWLSTGTNDLLAAEHMYDLLELVLLRLVLAGVLSPSTILEGLVYPTWSLASGLSEPRPAVSRLAGLANDLAERLLVVDDVPPAPSLLPPSTLSEVLELSARRLPASNNATFLDFINKFPCLVAMEIQPHIEPEVQASSRALRIMLVNQPQIATLSSRYMDVVRDSFLKPTGLVLNERLELLLVSVLKGIVNGGWTGLPGHKSSPVIDRVKQRPILTRIDPWGVTKASLDLHLTLKLLESSLEQDSSRAEAKERLADFSSSLFGRGMSSQSSDLVAGVLKGISGPVAAKFVNDGLERLTKGLRGLKLNQPDSVSTFVNDSGETLRLLCRVILPLRDDPSKLPSLETNIKDDFLSALQTALEAVLLTWKQPDHSVEPRRPEVATLIARLNQFALGFPEFWTKGTNEKGEALIVVYLQMMKAIGNPSLGDLGLFPILLDTIAFLLDEIPKVSRYPSTDALRQAIDPSRQLILPNLPKEYLDRVLPLLKFTSTDPCTGLALRFTQQPSRALLITHFPNRPWDWGESLEEGGGSDDKIRNSASIPLELFNAEMTHDRITQPDHDGPNRLWNSTENDEWHMKTVIGSETVFQREWVDSRVLDVSKREEGESSDEEMVDRAEEEDDEVPSGGQQGSGVYGKKRKASMSSIDEGMISDDDVQIIEGPDQGGR
Length1773
PositionKinase
OrganismThanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.07
Grand average of hydropathy-0.183
Instability index43.52
Isoelectric point6.28
Molecular weight197070.84
Publications
PubMed=23361014

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30472
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.53|      27|      36|    1708|    1737|       1
---------------------------------------------------------------------------
 1708- 1737 (43.30/36.04)	KREEGESS.DEEMVDraeEEDDEVPSGGQQG
 1744- 1771 (44.22/28.47)	KRKASMSSiDEGMIS...DDDVQIIEGPDQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.16|      22|      36|    1135|    1164|       2
---------------------------------------------------------------------------
 1135- 1164 (26.62/28.11)	RLVLAGVLSPStilEGLVYPtwslaSGLSE
 1182- 1203 (38.54/18.20)	RLLVVDDVPPA...PSLLPP.....STLSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.27|      23|      42|    1565|    1587|       3
---------------------------------------------------------------------------
 1565- 1587 (40.87/22.28)	ALRQAIDPSRQLILPNLPKEYLD
 1605- 1627 (44.41/24.85)	ALRFTQQPSRALLITHFPNRPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.79|      40|      42|      43|      82|       4
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   43-   82 (73.16/45.32)	HATTRGWS...GEGLSVPVRARGSTLVKPYGQFTNFIIDTLHT
   83-  125 (73.63/45.66)	HAAPRYRSkaiGYSLQTHCNAWGSQKFVPGTRRCTFHISAHHT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.05|      28|      42|     857|     884|       5
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  857-  884 (47.52/27.33)	TSTTLT.SLERYLSAGRYILMLAINDWLL
  900-  928 (46.53/26.61)	TRTKLTeHYQRSANEQRYLFPNCTNTFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.21|      16|      21|     252|     271|       8
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  252-  267 (30.27/24.54)	KPPSVSVTLLRWHL..GY
  274-  291 (25.95/ 8.68)	RPGQPEDTLTEHYVknGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     320.95|     141|     312|     659|     804|       9
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  615-  708 (71.32/39.21)	..............................................................................FAGVAARNDGLLFRVLPeravV......................................................................................................................................................dmratiadvqllnsigpgtdlsCASYFQPDGSDDQKLSV.............LLTWAVTPSQYGSHRPFLACSLLARRSEGTRWQ
  709-  804 (117.25/92.37)	EGIWrWLDESDEVRAVGIWENDKEEGLSTSAGIDDASKIMWHSRdAVALLVgELTEKGLFSYGWYMQKLIARGITDpnLARVASSHHRTLLHVLP....L...........................................................................................................................................................................................................................................
  977- 1039 (31.95/11.89)	....................................................................................................ssenttmsvmrsntlyrqgsnlqnqmvravckelqplllelvggmdpanepwtsttltslerylsagryilmlaindwllatvhqsldqwvghsrtrtkltehyqrsaneqrylfpnctntfvlqspcddildvviavierytniwvamdimneigeelfkkhqalhlehkhCRSLFTLLGSLSSAGSLpesahhqiesevnFITQSLHPQTDGTVDPSLSSSQIKSLVNDIPLE
 1046- 1118 (100.43/60.24)	DDIW.YKHHALESWATGIWDHVFASLCTVPQTTPDSQKSEIASR.YVTFLV.KLSSHSISGLDSYMREWLSTGTND...................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.04|      19|      27|    1382|    1406|      10
---------------------------------------------------------------------------
 1388- 1406 (34.49/33.31)	KGISG.....P.VAAKFVNDGLERL
 1408- 1432 (24.55/ 8.39)	KGLRGlklnqPdSVSTFVNDSGETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.28|      11|      28|    1500|    1510|      12
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 1500- 1510 (22.34/14.51)	ALGFPEFWTKG
 1528- 1538 (19.93/11.99)	AIGNPSLGDLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.12|      18|     371|    1210|    1229|      13
---------------------------------------------------------------------------
 1210- 1228 (26.94/24.95)	RRLPASNNATFLDFINKfP
 1241- 1258 (30.18/15.15)	PEVQASSRALRIMLVNQ.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30472 with Med12 domain of Kingdom Fungi
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