<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30471

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMFLPTRRVWTAGGASAGGAAASGAASDTPQGGQLQLITPVAQDQLMDVDLDLGIDLGLEMEVESATNDKDKDKEKEEETENENVKEKEATPVLDVPYFPLTPPQEDDTGGAWDPLKFGEKYQNVDDKYRGTQGKFGVRGGLTVPPSRPRARTFNQGRIEEGTARESWALSFCATPTSVLAKRIELGLGLRPRSSSSLSFQQQPSPQLQLSKSQPNPYVFQARPYPQLQLHHLPQFQLKNQLPTPSPSPNAHRKLRSGYINLTNPSAKRIRTLRLAHSQPVMSTNTARPVFARDWVPIVAPQSPTATVVSSASEDSDSSADDDDDEFIPGTAPRSAAPSRGTTPPTSAHPNGLLSSPPGPALLVAMFRPNALGSGMLGDVLTWTSQDSKEKPVVPVSVPTPVSPGEAAVAVGTVEAGVNVLAREAVDNWAWGADQVIQADTPTPATQPSRNELMLLGSCLSALALAPGSETMTLSKLTAVPKLDLPLPAIMTDRAYLVSPRLDKPRVPKVAVGHSGQVVQVYAPALRFWEVVGLEPVGGAKDVVAYAVVEEGEEVGVVKRWMERVGQVYETRRLGKHVVGDVGGGVVSVKWESMVKTLGEYSIRVLRGIANSVVVSFISSLPLTQSHIILYLIIPQRAFSSPALRSFIPTLESNKFISTLSEHRHRLSTHLVPASLLFDHSTTPPESRQRLVSTALSVYDRIPRTVGRRIRREIISLDIPAHTSVHVPAYTLARPLAPRFRFSMDWPDAQREVFDRHMFLHVGYSYSKSKRWLGATCIDERGEAYETKVWMCEEWSVGKVIAKVWSFAMRFAKRAAIEWRIVFCKMGEMEWDEVQAWEAHTSAKMSGDTRLGMHVSVLRFDLVTGLALSTSASPSVKAPVAPAGTPPSTVVDLTANDYLVLPGYDTEVCTIPDLDSPVSDSTPSVLPLATAHYFRLTDPPITRPMGRLTEIPSKTDDPPVGLLSSQLHLLHFNLTQNSSLWKSGGDPWRELLQSFYALTTLTQTRSIPPRVCHERDPGRVQGRTEITPETMLIEITHLGMVDCARDGLLSVYSLGRSRSEQDRQGDPDAVLGLWQFVEDRGARFLDPCLTDFLIMSVDLSATLIVYIFLACFDVVSERERDVVCFVLDLLSSYLTQRQDVMARELPMTQNVVLLAQIYAHELCIMAAYYRRESEGFSWSNQSDPGTLLNTVLLPLIQNLTHDQHQNIIYTLEEAEMILAYPLDMLDELITSWKSSKRNRELAMRLNRTAPSPNQKRSSGNTPRSECRKEMELLSSSNSQRPSPRTKSRTFRLTLPNLAIGTRINSFSSRDQKPFEKELQELVEYGPDVDCLCHTGHLCFIHAEGHPCDYEPKPKFPNSRELKRPESIFSDFQWAPPNQNGTSDRMSSVSMHMFRLTHSLRASGEDVKATVNGNAHVYSSPAFASSRVLSAGHLFENKHGNTDCQTCAGRLGHGGAQPPGHYIKPIGEQGEATNSLRPFTGKNIVVFCDGTGQDGLISSLSQEEKNDTQAQLEKIPKPKKKPFLDVAVTNTHRPGRSTMYASRSYSIKVVLGLATIFKVTPILGMITRRHAEQLPVSSLRVRIRLMVTELPWMA
Length1592
PositionKinase
OrganismThanatephorus cucumeris (strain AG1-IA) (Rice sheath blight fungus) (Rhizoctonia solani)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Cantharellales> Ceratobasidiaceae> Rhizoctonia> Rhizoctonia solani AG-1.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index48.67
Isoelectric point6.89
Molecular weight175714.95
Publications
PubMed=23361014

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30471
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     320.11|      98|     116|     225|     332|       1
---------------------------------------------------------------------------
  147-  265 (112.48/65.14)	RPRARTF....NQGRIEEGTARESWALSFcaTPtsVLAKRIELGLGLRPRSSSSLS.FQQQ..PSPQL......qlsksqpnpyvfqarpyPQLQLHhlPQFQLKNqlPtPSPS.......PNAhrkLRSGYIN..LTNPS
  266-  384 (144.43/68.62)	AKRIRTLrlAHSQPVMSTNTARPVFARDW..VP..IVAPQSPTATVVSSASEDSDS.SADD..DDDEFIPGTAP.......rsaapsrgttPPTSAH..PNGLLSS..P.PGPAllvamfrPNA...LGSGMLGdvLTWTS
  385-  447 (63.20/22.59)	QD.......SKEKPVVPVSVPTPVSPGEA..AV..AVGTVEAGVNVLAREAVDNWAwGADQviQADTPTPATQP...................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.94|      29|      29|     545|     573|       2
---------------------------------------------------------------------------
  510-  542 (32.25/20.07)	.AVGHSGQVVQVYApalRFWEVVGlePV..GGAKDV
  545-  573 (49.94/35.58)	YAVVEEGEEVGVVK...RWMERVG..QV..YETRRL
  576-  605 (34.75/22.26)	HVVGDVGG..GVVS..vKWESMVK..TLgeYSIRVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.41|      54|     116|    1313|    1379|       3
---------------------------------------------------------------------------
 1313- 1379 (86.07/85.68)	FEKelqelvEYGpDVDCLCHTGHLCfiHAEGHPCDYEPKPKFPNSRELK..RPES.....IFSDfqwaPPNQNG
 1433- 1493 (94.34/58.35)	FEN......KHG.NTDCQTCAGRLG..HGGAQPPGHYIKPIGEQGEATNslRPFTgknivVFCD....GTGQDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.20|      55|     521|     620|     679|       6
---------------------------------------------------------------------------
  620-  677 (89.35/63.46)	LPLTQSHiilYLIIPQRAFSSPALR.SFIPTLESNKFISTLSEHRHRLSTHLVPASLLF
  925-  980 (94.85/53.95)	LPLATAH...YFRLTDPPITRPMGRlTEIPSKTDDPPVGLLSSQLHLLHFNLTQNSSLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.75|      16|      30|     701|     719|       9
---------------------------------------------------------------------------
  701-  719 (23.50/18.03)	IPRTVGRRIRreiISLDIP
  731-  746 (32.25/16.85)	LARPLAPRFR...FSMDWP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.41|      18|      30|     828|     845|      10
---------------------------------------------------------------------------
  828-  845 (34.20/19.49)	MEWDEVQAWEAHTSAKMS
  857-  874 (29.21/15.64)	LRFDLVTGLALSTSASPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      17|      17|     471|     487|      14
---------------------------------------------------------------------------
  471-  487 (29.89/17.22)	MTLSKLTAVPKLDLP.LP
  490-  507 (27.21/14.97)	MTDRAYLVSPRLDKPrVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30471 with Med13 domain of Kingdom Fungi
Unable to open file!