<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30468

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMETRAAPVAASSPVASSASAVVREQLQQYARLASALLHSLLPSSATSTTPGPSSSSVASSGDRSAAALQKNASPEELMERLLRTDQALLRALNQLREHQRQQQRLARLKDEVAKKDGVVEQLALQLQQAQGTLQRVIDDTTTKLDRPLVPGGGSARRDGVDVDEVVAYAHKVSYTTSAPPNWNPNLPHMRMFLPPAPQEINILQGNFYHNSTSAPIPDFSDLTGAAKKEEADLGAPDLGAGPTLPMQQPLPFAGGPAPALIPIAELPPAPPSGLAPPPSEPVKQIMLDLNPDDEDSDSSSDLDDDEDDWV
Length310
PositionMiddle
OrganismAcanthamoeba castellanii str. Neff
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Discosea> Longamoebia> Centramoebida> Acanthamoebidae> Acanthamoeba.
Aromaticity0.03
Grand average of hydropathy-0.454
Instability index64.49
Isoelectric point4.65
Molecular weight32983.42
Publications
PubMed=23375108

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30468
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.59|      31|      33|     212|     242|       2
---------------------------------------------------------------------------
  176-  211 (43.40/19.55)	T...SAPpnwNPNLPHMRMflPPAPQEINI.LQGNFYHNS
  212-  242 (51.17/24.32)	T...SAP...IPDFSDLTG..AAKKEEADL.GAPDLGAGP
  243-  276 (42.01/18.70)	TlpmQQP...LP.FAGGPA..PALIPIAELpPAPPSGLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.59|      19|      26|      93|     111|       4
---------------------------------------------------------------------------
   93-  111 (32.61/23.28)	NQLR.EHQRQQQRLARLKDE
  120-  139 (26.98/18.03)	EQLAlQLQQAQGTLQRVIDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30468 with Med4 domain of Kingdom Amoebozoa
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