<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30464

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMENGYGTGAHTNHDRDGAPNGTNGALQASSRPAEKTGMPGHQQPPNQSVQLNGANGAPMTQSAGHSAGSVLKDANIQTKSTPPKINHITEGFESLPNLLTRLAQVTHNQLSGKLLELAGMNIQQSPDNSNAVSFVSGPDDNSAENIKKKVNLLKFAEGVHSNWTKALVITQWSRISEEVSRVIDLKAHLDEQKLYYDIAVHELSEVKRSLVHARLPNPDLRTAVEVLSTGKASWMPDLGYIEPPPLTAKEILQSLQNLNTLLSIRLNLHDYDKIPYHFRNYTIKSGRVTFRVEGEFEVDLTIADEDPEKQFWFIDFRFLFSPSPSVLTDQMRYSLEAKVNTVLEKDGLAGCYKVLHDLTLTHKISELRRQAYEIGRSRWIDALMVEPLRRSLSIQYWVDRCGKDGPKSWIIIGIISGKKKGAYPDEKETSQIGIRWFRDSKEVKDVEIPLELTTLSVEGLLRSIITMHVSHILESMYKSLRTKPLYENRDLVLSFKKPTTAEQEPELHVQLTSQYKINVIVEYITGKFAISPSSRLTSQAEYRLNNQTVDPASNGHEYIENLHCVLVSEDTVNRAYTVGWLPVRNPRLPQDELKPFLPRDTLQLSWFKKPGWDPNWYLALSSGMSGERWWLIEVTNVPEGPRPAADSIVLDGPTVRSHIQLPLKSVSPAPTYAFLSSLHLLSTSMISYYTNMRALHSRRSKFMLRNASKSTLSYRQGQPALYVMLSTLLPSKNRSPRTGKPWAKDVLKVSFQGIETLEQKEAATSPAGGSSQSPSNPPTAPSGPVGPRQSDTEEGAIMIAEGHMETAIPAGLLVKQHVDKDIAFHPSTSAFAFRLQARVGEPSIAPLIERLQRVERLVDFVQVINAHPYSLHCESVSLSRLIFSYGCVQSPSPNQPHTESPRYQAIIDFSSQTSKLELQLEAGNPHIRILDHLTKILNSPLGLHGLATILPLTLPVLRALDAAEDSWEDLPSSELQILCRAADWYAVRYILTPPSDGDNKSPAPPKRIIFEIRLHRRGNVPWWCMRRDQKHNATTVDPLDLALKEKVWTRSEKGVWMGMQCAAIAQTGGAEAMVLRVDSAMRDLAKDGTVFASAAPGVTGVKGEGAVPETTDGPGGQTGQAQVQAVNAPNKAQAQRPQTKSPVLQKQVQKKAQGPPTQQQRTQAALNEAPHRAQYQAQQLARQKEMHRQAQFQARQGQGQGQQRPNANANANGGGGNSGKQDAIVID
Length1232
PositionTail
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy-0.457
Instability index48.56
Isoelectric point8.81
Molecular weight136563.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.57|      50|      65|      46|      99|       1
---------------------------------------------------------------------------
   46-   99 (79.61/56.62)	HQQPPNQSVQLNGANgapMTQSAGHS.AGSVLK..DANiQTKSTPPKIN..HITEGFES
  112-  166 (70.95/39.42)	HNQLSGKLLELAGMN...IQQSPDNSnAVSFVSgpDDN.SAENIKKKVNllKFAEGVHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.72|      19|      70|    1125|    1143|       2
---------------------------------------------------------------------------
 1125- 1143 (34.61/19.86)	QAQVQAVNAPNKAQAQRPQ
 1152- 1168 (28.82/15.16)	QVQKKAQGPP..TQQQRTQ
 1194- 1211 (32.29/17.98)	QAQFQARQGQGQGQ.QRPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.88|      17|      70|     861|     877|       4
---------------------------------------------------------------------------
  861-  877 (30.29/19.08)	RLV.DFVQVINAHPYSLH
  885-  902 (28.60/17.57)	RLIfSYGCVQSPSPNQPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.81|      28|     111|     488|     518|       5
---------------------------------------------------------------------------
  488-  518 (45.77/30.93)	KPLYENRDLVLS.FKKPTtaeQEPELHVQLTS
  599-  627 (50.04/27.04)	KPFLPRDTLQLSwFKKPG...WDPNWYLALSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.06|      15|      15|     670|     684|       8
---------------------------------------------------------------------------
  670-  684 (26.62/17.17)	SVSPAPTYAFLSSLH
  687-  701 (27.45/17.94)	STSMISYYTNMRALH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.74|      16|      29|     183|     199|       9
---------------------------------------------------------------------------
  183-  199 (21.19/19.37)	EVSRVIdLKAHLDEQKL
  210-  225 (27.55/19.32)	EVKRSL.VHARLPNPDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30464 with Med14 domain of Kingdom Fungi
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