<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30463

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSTPIDSATNRSYPLSPTPNSEVKRSQPATFQPRTPQSPLQPNTASSEKVPNTRVSGNMSSTISRTVQGPAITDVHDSAMPMSIDSSIQADDLSNKRKRESEDTGGREQKKVHVEERKLCIEDLHLDVGKIYQLCRTPHPCNQPDLGLDLFELYGLNPTAAKVARVLPSGEKNGLRKTYKGKIKDLGISGKFDVTVNDEESSGGLLSMMREPEHEWMVTQRLGKEIEKGLPQNVFAALPAAMTMAKGVIPKQMWDSSVLGELDIPEKKPAAQVPSKPTSAGMQKSASQQSGAMSRGSKADLARPKRAVKKRGYDESSFEGYGEGYVDDDMVDAGYSTGEGDDRGGPGKRRKKSALNQQQYGPSRHGSYGPGMVGA
Length375
PositionHead
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.805
Instability index49.82
Isoelectric point8.87
Molecular weight40663.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30463
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.21|      12|      20|     123|     134|       1
---------------------------------------------------------------------------
  123-  134 (22.30/17.36)	DLHLDVGKIYQL
  145-  156 (21.91/16.94)	DLGLDLFELYGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.85|      17|      20|      14|      30|       2
---------------------------------------------------------------------------
   14-   30 (31.33/16.81)	PLSP.TPNSEVKRSQPAT
   36-   53 (27.53/14.00)	PQSPlQPNTASSEKVPNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.27|      41|     168|      70|     110|       3
---------------------------------------------------------------------------
   70-  110 (70.05/41.43)	PAITDVHDSAMPMSI.DSSIQAD.DLSNKR...KRESEDTGGREQK
  239-  284 (57.22/32.59)	PAAMTMAKGVIPKQMwDSSVLGElDIPEKKpaaQVPSKPTSAGMQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.16|      24|      45|     303|     326|       5
---------------------------------------------------------------------------
  303-  326 (44.30/25.91)	RPKRAVKKRGYDESSFEGYGEGYV
  350-  373 (45.86/27.06)	RKKSALNQQQYGPSRHGSYGPGMV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30463 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DMVDAGYSTGEGDDRGGPGKRRKKSALNQQQYGPSRHGSYGPGMVGA
2) MSTPIDSATNRSYPLSPTPNSEVKRSQPATFQPRTPQSPLQPNTASSEKVPNTRVSGNMSSTISRTVQGPAITDVHDSAMPMSIDSSIQADDLSNKRKRESEDTGGREQKKVHV
3) VLGELDIPEKKPAAQVPSKPTSAGMQKSASQQSGAMSRGSKADLARPKRAVKKRGYD
329
1
258
375
114
314










Molecular Recognition Features






MoRF SequenceStartStop




1) PGKRRKKSALNQQQYGPSRHGSYGPGMV
346
373