<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30462

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMMDDDMEVDIDDLFGDGAGGLLPPARPSPKELVQRVDELRGSGCCQSIAWSRWGSIASITSNGLGLEFRNLRIHPKDGSWDLSDATIIPQIAPIADGGQLKHLCWSPNGADLVAIDSAGRIAILNLGQSLNTPTFTRNSNVDPIEDLRAVVGAYWLNLSPSNLRQPGIQSVAVKTSTDYRYEISQAIAFGPCFPNAHKSALVTVSTGGTLSLLWPQADGKWYELSSEIEGISSSDDLITHASICADKNNTLLLAFATTAKKLSIARVAIKWGSPTANAPDRPVNPALNTVTPTIIIRLLSDTNWMDGSTSDPFHLSPSMAALSHLSILSPSPDGPGGRPTSPTVITIRSHLPNSLSQYNQDTHSLINRWELSEASPSVHPAFEQLSARRNSVGSKPGPSPSLKKQEGFTSNKVVIWMEAIYFERIICFGYSDGSVEYRDRTSLAELFTQGGLDKFSHISQIGFTYNGYEPSLVGALSPTHLSVVQKGCDGKIKMEPAASKFKHLPCKYSKPTPAFAFDLVSEVSKTLKFNVDYSEKSHHDSLIRNPSIQLSLSIQNALGYNGDAHKRTFESNIAWISLQLRNCVVLITMAMNIRVPIPDQQKNVLGLEDPEVIRLLAGSVRWCLDLMSWLIDCLLHPEGPEVFESVTKGEDGSIPLLSAHLLATNNIALHVLLSSATRGFLTGICRRLAHLDYTARKAMSAAQSVSAPPGQSAPLISNSLRSSYIAIATLTSSSIVPISRFEAFVARIADVVKEAYTAGKFPSQQQAQGVSGDCSRNDVEQGILFGGALPEVMAPAISRIFSEELPKLRAEIDPSRLFFHDFGILGLPESNASMGKGAMKGSATTSNAQYRVNHTIDIFSRVPIQLGVKPEEAQGLDARGSRPGRRWRRCVRCAAAMEDIHSLTPPVQFLIMQQRRCYCGGNWDILAGARVVA
Length936
PositionTail
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.07
Grand average of hydropathy-0.118
Instability index46.80
Isoelectric point6.75
Molecular weight101586.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.49|      87|     151|     320|     414|       1
---------------------------------------------------------------------------
  320-  414 (136.18/92.15)	PSM.AALS..HLSILSPSPDGPggRPTSPTVITIRsHLPnslSQYNQDTHSLInrWEL.SEASPSVHPAFE.QLSARRNSVGSKPGPSPSLKKQEGFTSN
  473-  564 (133.31/70.58)	PSLvGALSptHLSVVQKGCDGK..IKMEPAASKFK.HLP...CKYSKPTPAFA..FDLvSEVSKTLKFNVDySEKSHHDSLIRNPSIQLSLSIQNALGYN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.69|      26|     316|     282|     309|       2
---------------------------------------------------------------------------
  282-  309 (40.03/29.68)	PDRPVNpALNTVTPTiIIRLLSDT.NW.MD
  601-  628 (38.66/19.92)	PDQQKN.VLGLEDPE.VIRLLAGSvRWcLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.86|      36|      56|      31|      66|       3
---------------------------------------------------------------------------
   31-   66 (64.40/36.70)	SPKELVQRVDELRGSGCCQSIAWSRWGS.IASITSNG
   86-  122 (58.46/32.65)	SDATIIPQIAPIADGGQLKHLCWSPNGAdLVAIDSAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30462 with Med16 domain of Kingdom Fungi
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