<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30451

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDIGDYGTNVVCTYELNSIAYSYFECPSEETSVSTGLYKLVAELQQVGILAAKDNKKAGLWIFETGDNAEPASSPSGGAQLSSRASNLGIDLTLKHSGSYDSNALLESWKSLSKPPTNTISSPSTDSGEPLSQKESFEKHFRAAQAAIMNKEASVNNSLIGLNNDDGTLNPTLKDRARQFQLLAQSRLRLHIHDYFLTAVFLSLGYALCLDHGYIPLSSRTLVVPKSNLGTTGPQTTTQSNNGNGDDRLQLVTLSSDYTGSKVLVIKATLTTSTSYIGCDLPRFVKHEDVPIPANATLILGPGGSTGNFKGLANNGFQSTVSKYATGSDETQHSGNEGQSSMSHRLRSRCLEWLVGKGINKERLENSAWFMVGLYLNQLTNNPRQGLSEERVLIPWPSFLCFRQTDNTLSANDAFGTLSTYDPLGFAQTWYAGQQDREATIIRRKKERDAAEAVAKVQADSEAQDLHSLYSPLALRRSSVAGLVYPTPPDGVQHTVGATPTFDEAVSTPGQQGLPLSTDASNSLVTKTEADSNGPLDIASHTDFDFQDTSNGNLFGDAGDDLFGEENDITDADFSFFDEPDIFQGNQDVDMPGQDNTAGVVENELTLSPKDDLNMGDVPEMADVHMGNTDESPVEESLPPDLPSDTNPARQIEIKTEPSLEGPETSTDEPSPPLKPEYVFGRLSTFDVFSKPLLTKPQEDTSAIVLDPAGSFGGVDFKALFASLHQKYGSHGRFIYPPPKVLPNTLRAKFPTTDYFNRRRRRKLAGKSSIVGGVHTGTDHRFLVPGQAITFEQPAQRGSRSPSPSSDQDDSSDEMDGSFTHNSSSLKRRHQVEDNSESNDDEEITSSFQELQVNQADETNNATLDTVYPFALDSDFTRWSAAMFLAWPNPWANEYTLTDAEYIAAAQILGDQAISYTLRYPNDGNRHCGSLEGNIKATYTPDLIRQDVVLAAKKYFKGANPQTLSNFLDMQGVPRQLAGINRLPPRPIPSSQGSQGSQGSSPAKPNPIFPLPSPHLQLRRSDSRLSVLPSALPFWDVLGLAPRGNGKHVTSLCVFPKAVGMAESADLFLENIRSAYETRRLGSHERLNTEGSVNGLLPIELGGQATRFASDQGLSVIREALFQVANLLASSSADSTNFVVYFVYDPESPDILVPICSAFHSMFEVYKTAMAGKTVSNELVLQLVPLNFVSARTHLVVLPPTDYTRLAMEVYDRCFDFQAGVASPSVAIEPPLPRTIDFKLTANPSASLLQENSCLQIAYAQSIDYRWITAAWSDNTGSDQMTASYCLGRQDAPLTRQFSDIAHEIWETTLDIIASKKVHWRVIIAKCGIMEAQDVRFWKGLSETERNAQISLTLLSVDTQPALQLLPPGLSIPASTLAAQSTFYTTPVSTPQPASILSPDQSGCTPTATPTDGTGELKIEPDATLIDLTNQSYGAVLAHRVNNSNSPLEVRPTAISGYLIKRTGASSSDVPAVMEVNIVWTDINPRLAENPLKEILAWYSGLATLAKARGIVDPVKDTRPWHIAAAEKAVRLLYLLM
Length1537
PositionKinase
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.08
Grand average of hydropathy-0.353
Instability index44.09
Isoelectric point4.95
Molecular weight167327.74
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30451
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.08|      24|     205|     941|     985|       1
---------------------------------------------------------------------------
  962-  985 (44.35/54.79)	QTLSNFLDMQGVPRQLAGINR....LPP
 1173- 1200 (35.73/ 9.62)	KTVSNELVLQLVPLNFVSARThlvvLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     326.38|     106|     206|      98|     217|       2
---------------------------------------------------------------------------
   98-  207 (169.71/122.00)	GSYD..SNALLESwkSLSKPPTNtiSSPSTDSGEPLSQKESFEKHFRAAQAAI...MNKEASVNNS..LIGLNNDDGTLNPTL...KDRA....RQFQLLAQSRLRLHIHDYFLT.AVFLSLGYA
  307-  427 (156.67/84.42)	GNFKglANNGFQS..TVSKYATG..SDETQHSGNEGQSSMSHRLRSRCLEWLVgkgINKERLENSAwfMVGLYLNQLTNNPRQglsEERVlipwPSFLCFRQTDNTLSANDAFGTlSTYDPLGFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      22|     205|     628|     649|       4
---------------------------------------------------------------------------
  623-  644 (38.97/21.59)	DVHMGNTDESPVEESLP.PDLPS
  645-  667 (32.97/17.08)	DTNPARQIEIKTEPSLEgPETST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.25|      47|     181|     486|     537|       8
---------------------------------------------------------------------------
  486-  509 (26.13/ 8.64)	............................................................................................................................................................PTPPDGVQHTVGATPTFDeAVSTP
  514-  537 (25.68/10.01)	LPLSTDASNSLVTKTEADSNGPLD............................................................................................................................................................
  670-  692 (29.07/ 7.14)	........................iashtdfdfqdtsngnlfgdagddlfgeenditdadfsffdepdifqgnqdvdmpgqdntagvveneltlspkddlnmgdvpemadvhmgntdespveeslppdlpsdtnparqieiktepslegpetstdePSPPLKPEYVFGRLSTFD.VFSKP
  693-  748 (41.37/10.99)	LLTKPQEDTSAIVLDPAGSFGGVD................................................................................................................fkalfaslhqkygshgrfiyP.PPKVLPNTLRA...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.36|      51|     184|    1298|    1355|       9
---------------------------------------------------------------------------
 1298- 1355 (76.34/78.11)	FSDIAHEIWETTL.DIIAskkvhWR...VIIAKC.GIME.AQDVRFWKgLSETERNAQIsLTLL
 1480- 1536 (72.03/51.68)	WTDINPRLAENPLkEILA.....WYsglATLAKArGIVDpVKDTRPWH.IAAAEKAVRL.LYLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30451 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DFSFFDEPDIFQGNQDVDMPGQDNTAGVVENELTLSPKDDLNMGDVPEMADVHMGNTDESPVEESLPPDLPSDTNPARQIEIKTEPSLEGPETSTDEPSPPLKPE
2) GINRLPPRPIPSSQGSQGSQGSSPAKPNPIFPLPSPH
3) PGQAITFEQPAQRGSRSPSPSSDQDDSSDEMDGSFTHNSSSLKRRHQVEDNSESNDDEEITSSFQELQVNQADET
4) PTPPDGVQHTVGATPTFDEAVSTPGQQGLPLSTDASNSLVTKTEADSNGPLDIASHTDFDFQDTSNGNLFGDAGDDLFGEENDITD
573
979
785
486
677
1015
859
571










Molecular Recognition Features






MoRF SequenceStartStop




1) EENDITDADFSFFDEPD
565
581