<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30450

Description CMGC/CDK/CDK8 protein kinase
SequenceMFPQRFDAYWSDPYLGLREPANRSSGHVAYQSKVRVVDRYKVIGFISSGTYGRVYKAAGRIGQTGEFAIKKFKPDKEGEQIHYTGISQSAVREMALCSELSHINVIKLIEIILEDKCIYMVFEYAEHDLLQIIHHHTQPTRHPIPPATVKSIMFQLLNGCQYLHSNWVLHRDLKPANIMVTSAGEVRIGDLGLARLFSKPLHSLFSGDKVVVTIWYRAPELLLGSRHYTPAIDMWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRHQMQKIIDIMGLPTKDKWPLLVSMPEYANLSSLHAPVQPNGKPAGSKLESWYYSTIGQHSGTSQPASSSLGAEGYKLLAGLLEYDPDKRLTAQQALEHPFFSTGDKVSSNCFEGMKTEYPHRRVSQDDNDIRTGSLPGTKRSGLPDDTLARPSKRMKEN
Length427
PositionKinase
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.09
Grand average of hydropathy-0.371
Instability index39.43
Isoelectric point9.02
Molecular weight48059.59
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30450
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.17|      63|     279|      10|      76|       1
---------------------------------------------------------------------------
   10-   76 (100.08/74.32)	WsdPYL.GLREPANRSSGHVAYQ.......SKVRVVdRYKVIGfISSGTYGRVYKAAGRIGQTGEFAIKKFKPDK
  286-  356 (104.09/62.58)	W..PLLvSMPEYANLSSLHAPVQpngkpagSKLESW.YYSTIG.QHSGTSQPASSSLGAEGYKLLAGLLEYDPDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.29|      43|      90|     115|     157|       2
---------------------------------------------------------------------------
  115-  157 (76.59/46.09)	DKCIYMVFEYAEHDLLQIIHHHTQPTRHPIPPATVKSIMFQLL
  158-  191 (53.83/30.48)	NGCQYLHSNW.......VLHRDLKPANIMVTSAG..EVRIGDL
  208-  245 (63.88/37.37)	DKVVVTIW.YRAPELLLGSRHYT.PA...IDMWAVGCIFAELL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30450 with CDK8 domain of Kingdom Fungi
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