<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30448

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDEWATFFAHALDRRLPTDKLEQFAKVLSIKAPLATPLIAELLLRPSESRHYDLDPQVSLYAQALLRTDILDVPSVLRALLRHSTSRPVDAAKEEQEVASGSQTRWTKSYGHEERLVYGLSKIVAAGDRPKSAQEALGTANVLTEWMRLLVMSNAADDMMREIGAGNDNHNQEAMAVRVAVGALLVALAENATVNEALKNRCPKDTLKGFSQSLAHFTPLLINGSSMFAERLELYTKTLVAMEPIDKKAQKAGAEIDQIIDSAMALGMDNIPVVEIPTMNSRAGLYVYLNSLLTGRPMVDDNQLLNFLHNRYQGDIQTTCIDLIVSSFDILANAIFRSENPQTTFLLRSFLINKVPLLICMISAPMFPPLSPELCITEALSHVDTNAFPTFSSMFDDNSAGDMFSDSVRQDFCFSCCLHGLIPEESIERLLGEIPMQTLPAGGRYSKDEVLEQCLSDSEKIEAFTDELEHMDGNVGAVSQAITELLRRLCESKDTMALKSLCAHLARKPSSLDVLLIFDKPLTILPPICQLLDAWRYDDDQGEYQPVYEDFGSILLLVLAFVYRYDLSATELGVQTPDSFIAKLLVRVSTARLLDDLSSVESSQLDGWIKGLFNAEGGGLGDEPMALCPPQDFYLLVPTLFSQIVLASQHGHLTDDVLRGGLEYLLDPSLLPSLIPALLSLASNILTAPPPPSLLQALILPQSISAEASLLHNAILPIPAPHLSRSLRALQRSAPTRTDLDPLIAALRPHLHFSRTTIDITTDFPVPPNIPTAVRHAARALINWNPPAAPPNYSPRLPVLAVRMLGARRALLALLEELAHQCALGNSGTAYDVVASLVCAPPKAAAGVQGRMTLREALSSEAAKVGAEVGKEGPEAERAEVVVRLYRRVEALSAGGEIDEQAGLMGTDLGIGGVGGEGLVGEDMMGVLSEEGMMGLEGGMLDDMKLDF
Length948
PositionTail
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.06
Grand average of hydropathy0.054
Instability index45.17
Isoelectric point4.83
Molecular weight103133.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30448
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.31|      21|      27|     755|     781|       1
---------------------------------------------------------------------------
  755-  775 (38.38/18.60)	RTTIDITTDFPV.PPNIPTAVR
  828-  849 (29.93/17.28)	GTAYDVVASLVCaPPKAAAGVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.28|      20|      39|      34|      53|       2
---------------------------------------------------------------------------
   34-   53 (35.32/18.45)	LATPLIAELLLRPSESRHYD
   71-   90 (34.96/18.19)	LDVPSVLRALLRHSTSRPVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.35|      27|      27|     670|     696|       3
---------------------------------------------------------------------------
  330-  360 (34.63/17.39)	ILANAIFRSENPQTTF.............LLRSFlinkVPLLIC
  681-  709 (35.59/18.09)	LASNILTAPPPPSLLQ...........alILPQS....ISAEAS
  710-  747 (26.13/11.17)	LLHNAILPIPAPHLSRslralqrsaptrtDLDPL....IAAL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.51|      21|      36|     618|     641|       4
---------------------------------------------------------------------------
  618-  641 (31.57/27.35)	GGLGDEpmALCPPQDfYLLVPTLF
  651-  671 (37.94/20.11)	GHLTDD..VLRGGLE.YLLDPSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.97|      15|      17|     904|     918|       5
---------------------------------------------------------------------------
  904-  918 (27.74/17.53)	LMGTDLGIGGVGGEG
  924-  938 (28.23/17.98)	MMGVLSEEGMMGLEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.40|      22|      36|     410|     434|       6
---------------------------------------------------------------------------
  410-  434 (35.97/33.22)	QDFCFSCCLHGlipEESIERLLGEI
  447-  468 (36.43/24.05)	KDEVLEQCLSD...SEKIEAFTDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.67|      15|      31|     555|     585|       7
---------------------------------------------------------------------------
  535-  551 (27.05/18.58)	WRYD...DDQGEYQPvyEDF
  563-  580 (23.62/18.01)	YRYDlsaTELGVQTP..DSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      13|      21|     210|     222|      12
---------------------------------------------------------------------------
  210-  222 (22.57/15.87)	FSQSLAHFTPLLI
  228-  240 (21.10/14.30)	FAERLELYTKTLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.28|      25|     623|     175|     200|      14
---------------------------------------------------------------------------
  175-  200 (36.32/25.20)	MAVRVaVGA..LLVALAENATVNEALKN
  800-  826 (37.95/21.92)	LAVRM.LGArrALLALLEELAHQCALGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30448 with Med5 domain of Kingdom Fungi
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