<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30446

Description Uncharacterized protein
SequenceMSTRPPQPGPRPPQHSLGGTGMLQRQAQQRSHLQQSQQPSRGRTSDSVVEVIADGAETAPPRLEPSKPGGSMVRVEGLTAQKQNIVSMELPSQAGTPGAVMPLPKRAGQRIPFRRHDAQSDAPKQVGSPHKSSANLPLPMPARPGRSGVSHIRRQAHDAGNSPKKESRPKPYVLEAPLDAPSYTSNGHLDYFPWTGTRDEDTFNDNVIRQGYFDKIQTGQNETASAKQQLYPSLRLKNGLQTLGSLFAHVLGQRRQHSQITAAPSFKPPPRVTLTDTKRETWLRDLANPLIPLRRLSRTIPHGIKNKVLLEQCTRKNVPTERAVWLAKCVGANEIRASKRKGVPGALAMGGESKWIRDWTVCVEQFVDGVVTAGGDKDWKSKVLYSIRLSAHLYSEQLLDTEHYLDWLLSSLESTPLTRLPIWLLIAEVYWADILRYRKSARRLVAALCSNLQDAHESPDRDLLLPLIERVGNIVTATVQTNPESFIALSHWPKYSDTLVACNTSGGPDETQIFDAISRRNARLKSRSSGGDETQNSRRLVIDLLDASLSVQFSQDLPRECWKGMRDRILLVQTLFDWATSCARPSLMKTFVAARLMRTWSRHGVDVDESVLNYLTFRSNGHGVSSDAVYHLVSELARSGHFSVSKYIQWVIARGGLHGSQDVAADGPCVTRLLAELPVHDLPENLLKIRKTLLNRASFSVNDETETIDNMSLAFERCSPNLYGKTPSGEEAPTAADVVQNITHLSRTVKAELGLRLRKQINLRMTKASPSETGEWKAGPEYETATTVTVADFNLTRAVLEATEDLSILADILKLVSSSSSTQILASIADTLNMHRLTFSAIGALNDLFDTLVLRQCSLGVIQGPESVTLLHSLCALSATIPDVANIHVQLSRDVARSVRRSAADACSPVSDHVAEALQKSDGDISDEVDKLLSSGTSMDAPTLKRLFQVIINQMEASWAKSDPGLQKHGPILERLRTFDTKQFDTLLTPWVEQMILKSDRPNLGHVLGPLISAGCLSFKEHLKVSASSVQKTRDGGDKPTTSRIAFESLSLVLNTYRNGDIMSVEDAYTLNIRQTQAQLKDHLAILKIARIAIEISEPSADNNDVTINLLCLGDAFRRFLRRLVLTEFDCVLKEFVTPLAKSQDLHIISCLRAILCGLLDLKTTTGTEDLVVARQIEVIFGVASDLTLPFCQLALRSLSASEIPGSSSESAADTSRLEAYERAVDTALANNNPTWTKIIPTLDAQIAQHLCDQAERSLLATIPSFKPPSFDSPAPTKPPSDPALAKRMLFVISATAYSTQNLGHNTTALDIGEKINNLAHALSQPQSMQTYSQTTTWLPLMLEYITTHASTLPTSRPATDVRARVLLALSALLLALHAHTGTDALSEHVLDVSLLLVDELPDDARAQCGRFLAERGKEVVLGDPGLRYVFGLESGGGQGEAGGGGTLMISQRGRMEGFVVRRWECLSEPTPLVGENDAALSLSLFQARR
Length1490
PositionKinase
OrganismPseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21) (Bat white-nose syndrome fungus) (Geomyces destructans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Pseudeurotiaceae> Pseudogymnoascus.
Aromaticity0.05
Grand average of hydropathy-0.256
Instability index45.74
Isoelectric point7.96
Molecular weight163450.12
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30446
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     469.08|     156|     175|     912|    1083|       1
---------------------------------------------------------------------------
  912- 1083 (228.13/201.86)	DHVAEALQKSDGDISDEVDKLLSSGTSMDaPTLKRL....FQVIINQMEASWAKSDpGLqkHgpILERLRTFDTKQFDTLLTPWVEQMILKSDRPNLGHVLGPLISAGC.LSFKehlKVSASSVQKTRDGGDKPtTSRI.AFE...SLSLVLNTYRNGDIMSVEDAytlnirQTQAQLKDH
 1090- 1254 (240.95/164.14)	ARIAIEISEPSADNNDVTINLLCLGDAFR.RFLRRLvlteFDCVLKEFVTPLAKSQ.DL..H..IISCLRAILCGLLDLKTTTGTEDLVVARQIEVIFGVASDLTLPFCqLALR...SLSASEIPGSSSESAAD.TSRLeAYEravDTALANNNPTWTKIIPTLDA......QIAQHLCDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.45|      44|     174|      70|     115|       2
---------------------------------------------------------------------------
   70-  115 (76.18/49.15)	GSM.VRVEGLTAQKQNIVSMelPSQAGTPGAVMPLPKR.......AGQRIPFRR
  244-  295 (65.28/36.41)	GSLfAHVLGQRRQHSQITAA..PSFKPPPRVTLTDTKRetwlrdlANPLIPLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.00|      15|      18|     626|     643|       4
---------------------------------------------------------------------------
  626-  643 (22.20/23.95)	SDAVYHLVselARSG.HFS
  645-  660 (24.81/16.49)	SKYIQWVI...ARGGlHGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.50|      13|      18|     803|     820|       5
---------------------------------------------------------------------------
  803-  815 (20.15/24.30)	TEDLSILADILKL
  822-  834 (21.35/ 8.80)	TQILASIADTLNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.18|      11|      21|     505|     520|       6
---------------------------------------------------------------------------
  505-  520 (12.92/21.85)	SGGpDETQifdaISRR
  529-  539 (23.26/13.07)	SGG.DETQ....NSRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.48|      28|     174|     396|     423|       7
---------------------------------------------------------------------------
  396-  423 (50.94/28.90)	EQLLDTEHYLDWLLS....SLESTPL.TRL.PIW
  545-  562 (24.45/10.20)	.........LDASLS....VQFSQDL.PR..ECW
  567-  600 (33.10/16.31)	DRILLVQTLFDWATScarpSLMKTFVaARLmRTW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.03|      10|      17|     308|     317|       8
---------------------------------------------------------------------------
  308-  317 (17.82/11.01)	VLLEQCTRKN
  324-  333 (19.21/12.48)	VWLAKCVGAN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30446 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTRPPQPGPRPPQHSLGGTGMLQRQAQQRSHLQQSQQPSRGRTSDSVVEVIADGAETAPPRLEPSKPGGSMVRVEGLTAQKQNIVSMELPSQAGTPGAVMPLPKRAGQRIPFRRHDAQSDAPKQVGSPHKSSANLPLPMPARPGRSGVSHIRRQAHDAGNSPKKESRPKPYVLEAPLDA
1
180










Molecular Recognition Features






MoRF SequenceStartStop




1) KRAGQRIPFRRHD
2) MLQRQA
105
22
117
27