<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30445

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMSSLLERLHSKYSQNRPWPETIKLVRQIMEKRTGMMSGSHQHLVSCLETLQKALKVSSLSAMTDRLESIARQNGLTSHLSPNGTECYITTDMFYLEVLLDTEGQLCDVKVAHHRENPVSCPELVEQLREKNFEDFSQHLKGLVNLYKVPGDNKLETKMYLALQSLELDLTKMAAMYWQATNASVLEKILHGTVGYLTPRSGGQVMSLKYYVSPYDLFDDTTGASISLSEGHAVPRSLGMNVSVTIEATSAMYKLPIAPLIMGSHPIDNKGTPSFTSITNANSVDLPACFFLKFPQPIPVSRAFIQKIQHCTGISLIDGSHTFLPHYELVTQFELAKEKEPGTLNHNMRFYASLPGQQHCYFVNKDAPLPDGRSLQGTLLSKIPFQHPGRVPIILSLIRHQVACNTLIGSCVKRTMLKEDCPGLLQFEVAPLSDSCFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFITKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMASGSTALSGITTPTSSYTSGQISSLFNMGIKERHDSAGHGDDFSKVTQNPILTSLLQITSNSGGTLGSSPTPPQHTPPPASSPASNTKNHPMLMNLLKDNPAQDFSTLYGGSPLERQNSSGSPRTELGSSASGKPKKKRPRTGTEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPNVYQQAIPHTQANMQRMVRIPSTDAIIPDVTDILSDIAEEASKLPGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFNPDLLNSQSQSGFTDDLNDDSSQSGDNDFKDFAGPGLASLGIVSGLPVDGGDGKYKMALGADTVDFSIIAGGGSKNLGGPDIQETQSRSQSPLLGSDLGKDRPQKQKVKESGNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTMSVGKPSSHSQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSNSQSKNSSQSMGKAGSSPITKHGLSSNVNNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKLSSPMKPMPGTPPSSKAKSPIGSGGQHLSGSGSNSTTKSSSGLVSSGSLTQKPNSSSSSSFSSGVSQNLHSSSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGVGGGSTGAPSHGMSSKHGLGVGEFPTKREKGEKDKSKGSSGGPSDPSKKGGGDSKGSVSTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGEGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSESYTMKPESWSKSPISADPTMAMGGGAMMSSDRASRPTPSFLMGDDDDLIDVPLTL
Length1533
PositionMiddle
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KingdomMetazoa
Lineage
Aromaticity0.04
Grand average of hydropathy-0.578
Instability index52.77
Isoelectric point8.42
Molecular weight161196.19
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30445
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1050.19|     148|     148|     958|    1105|       1
---------------------------------------------------------------------------
  522-  643 (126.63/31.02)	....................................VKKN...............LPP.ASSPG......YGMASG.....ST.......................AL..SGI.TTPTSSYTS.GQISSlfnmgiKE....RH............DSAG.........HGDDFSKVTQ.NPILTS..L.LQI...TSNSGGTLGSSPTP....PQHTPPPAssPASNTKNHPMLMNL.LKDN.....PA..........QDFST
  646-  771 (110.32/25.98)	GGS......PLE..RQNSS..GSPRT.ELGSSASGKPKKK...............RPR..TGT..............EKMKNQteddfqrelfsmdvdsqntifdvGM..AGD.AL....................DTP...................................HIT......................PAPS.QCGTP....PNVYQQAI..PHTQANMQR..M.V.RIPS.....TDaiipdvtdilSDIAE
  772-  935 (144.58/36.55)	EAS......KLP..GPGEDcpNLGTP.VRDSSSSGHSQST...........lfdtDVF.QVDGG......GGSGGENPYPDPV.......................DLivDSH.GSPNSDSPN.TFFNS......VDFNPDLL............NSQSqsgftddlnDDSSQSGDNDfKDFAGPglA.SLGivsGLPVDGGDGKYKMA....LGADTVDF..SIIA...GGGSKNL.GGPD.....IQ..........E....
  936- 1076 (222.24/60.50)	..........TQ..SRSQS........PLLGSDLGKDRPQ.............kqKVK.ESGNG......GGAGGGLSGMQSA.......................GM..EGK.SMKRSRTPS.SDGKS......KDKPPKRK............KTES.........DGKSPSHITN.RPFTPP..T.STG...GSKSPGTSGRSQTP....PGMATPPI..PKITIQIPKGTMSV.GKPS.....SH..........SQYSS
 1077- 1243 (174.20/45.69)	SGS......SSS..SSSKS..HHGHS.SLSSSASGKIKSN.............ksD.G.SSGMK......IGSSGG..GMYS........................GQ..SGQ.SNSQSKNSSqSMGKA......GSSPITKHglssnvnnssgsKTKP.........QGK.PSVLMN.PSLSKP..NiSPS...HSRPSGGSDKLSSPmkpmPG..TPPS..SKAKSPIGSGGQHLsGSGSnsttkSS..........SGLVS
 1244- 1412 (158.54/40.86)	SGSltqkpnSSS..SSSFS..S.GVSqNLHSSSKGKSPSRnkkpsltavidklkhGVG.TGGPGsedpmdGGVGGGSTGAPSH.......................GM..SSKhGLGVGEFPT.K..........REKGEKDK............SKGS.........SG.GPSDPSK.K...GG..G.DSK...GSVSTGVAKIIISK....HDGGSPSI.kAKVTLQKPEGGGEG.LRSQ.....MQ..........KNYGS
 1416- 1516 (113.68/27.02)	SGS......TPKheRCSPS..HNKSP.AYTPQA...LDSE..................sESGSS......SIAEKSYQNSPSS.......................DD..GGG.SGSRAQTEY.SESYT......M.KP..................ES.........WSKSP..IS.....ADP..T.MAM...GGGAMMSSDR...........ASRPT..P........................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.02|      35|      51|     139|     175|       2
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  139-  175 (50.89/42.71)	LKGLVNlYKVP..GDNKLETKMYLALQSLeLDLTKMAAM
  189-  225 (59.13/39.71)	LHGTVG.YLTPrsGGQVMSLKYYVSPYDL.FDDTTGASI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.61|      30|     278|      11|      43|       3
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   11-   43 (47.77/38.42)	KYSQnrPWPETIKLVRQImEKRTG..MMSGSHQHL
  292-  323 (51.84/30.29)	KFPQ..PIPVSRAFIQKI.QHCTGisLIDGSHTFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30445 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IIAGGGSKNLGGPDIQETQSRSQSPLLGSDLGKDRPQKQKVKESGNGGGAGGGLSGMQSAGMEGKSMKRSRTPSSDGKSKDKPPKRKKTESDGKSPSHITNRPFTPPTSTGGSKSPGTSGRSQTPPGMATPPIPKITIQIPKGTMSVGKPSSHSQYSSSGSSSSSSSKSHHGHSSLSSSASGKIKSNKSDGSSGMKIGSSGGGMYSGQSGQSNSQSKNSSQSMGKAGSSPITKHGLSSNVNNSSGSKTKPQGKPSVLMNPSLSKPNISPSHSRPSGGSDKLSSPMKPMPGTPPSSKAKSPIGSGGQHLSGSGSNSTTKSSSGLVSSGSLTQKPNSSSSSSFSSGVSQNLHSSSKGKSPSRNKKPSLTAVIDKLKHGVGTGGPGSEDPMDGGVGGGSTGAPSHGMSSKHGLGVGEFPTKREKGEKDKSKGSSGGPSDPSKKGGGDSKGSVSTGVAKIIISKHDGGSPSIKAKVTLQKPEGGGEGLRSQMQKNYGSPLISGSTPKHERCSPSHNKSPAYTPQALDSESESGSSSIAEKSYQNSPSSDDGGGSGSRAQTEYSESYTMKPESWSKSPISADPTMAMGGGAMMSSDRASRPTPSFLMGDDDDLIDVPLTL
2) LNSQSQSGFTDDLNDDSSQSGDNDFKDFAG
3) MGIKERHDSAGHGDDFSKVTQNPILTSLLQITSNSGGTLGSSPTPPQHTPPPASSPASNTKNHPMLMNLLKDNPAQDFSTLYGGSPLERQNSSGSPRTELGSSASGKPKKKRPRTGTEKMKNQTEDDFQRELFSMDVDSQNTIFDVGMAGDALDTPHITPAPSQCGTPPNVYQQAIPHTQANMQRMVRIPSTDAI
4) PDVTDILSDIAEEASKLPGPGEDCPNLGTPVRDSSSSGHSQSTLFDTDVFQVDGGGGSGGENPYPDPVDLIVDSHGSPNSDSPNTFFNSVDFN
919
856
564
760
1533
885
758
852










Molecular Recognition Features






MoRF SequenceStartStop




1) FLMGDDDDLIDV
2) GVAKIIISKH
3) IAEKSYQ
4) IKAKVTL
5) NKKPSLTAVIDKLKHGV
6) PIPKITIQIPKGTM
7) SKHGLGVGEFPTKREK
1518
1370
1451
1386
1279
1050
1324
1529
1379
1457
1392
1295
1063
1339