<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30439

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPVHQNEATLRGLAGAPGSANGGAHNCRPEAGMASVPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGPLDSSGHVGPEGSRLEHSENDKHSSKIPINAVRPHTSSPGLGKPPGPCLQSKAAVLQQLDRADETPGPPHPKGLPRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSPRPQSLDTTQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPEGHQRLVGPGCKAGPPQAEPLLPRAGFSPDSSRADSDAASSGGSDSKKKKRYRPRDYTVNLDGRVTEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRANSPIHTEQPRTELDKPEAKANLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARTPHVLLPPGPPTDLPGLSRQVTQDDLDRIQAHQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length572
PositionUnknown
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.04
Grand average of hydropathy-0.895
Instability index59.91
Isoelectric point9.47
Molecular weight62576.62
Publications
PubMed=23258410

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30439
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.79|      22|      25|     228|     249|       1
---------------------------------------------------------------------------
  181-  202 (26.99/ 7.71)	RLEHSENDKHSSKIPINAVRPH
  228-  249 (43.80/17.38)	RADETPGPPHPKGLPRCSFSPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     290.50|      62|     135|     118|     179|       2
---------------------------------------------------------------------------
   69-  123 (54.80/17.91)	......GLAGAPG...SANGGA................................HNC.......R....PEAGMASVPKSI.HD...LKNRNDIQrlP.GqrldrlGSRKR..R
  124-  179 (96.88/37.51)	GDQRDLGHPGPPP...KVSKAS................................HDSLVPNSSPL....PTNGIGGSPESFPGP...LDSSGHVG..PEG..............
  203-  283 (50.89/16.09)	TSSPGLGKPPGPC...LQSKAAvlqqldradetpgpphpkglprcsfsprnsrhEGSFARQRSPY....TPKGSVPSPSPRPQS...LDTT.......................
  331-  378 (45.78/13.71)	........AGPP.........Q................................AEPL......L....PRAGF..SPDSSRAD...SDAASSGG..SDSkkkkryRPRDYtvN
  379-  432 (42.16/12.03)	LDGR.VTEAGVKPvrlKERKLT................................FDPMTRQIKPLtqkePVR..ANSPIHTEQPrteLD.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.95|      15|      22|     461|     477|       3
---------------------------------------------------------------------------
  461-  477 (22.34/17.96)	YLSRQSSllSSSGAQTP
  486-  500 (27.61/15.83)	YLKQEES..TRRGARTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.57|      33|     208|     294|     330|       4
---------------------------------------------------------------------------
  294-  330 (59.39/35.47)	PSTPPVRrlelLPSAESPVCW..LEQPEGHQRLVGPGCK
  505-  539 (60.18/28.70)	PPGPPTD....LPGLSRQVTQddLDRIQAHQWPGVNGCQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30439 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQNEATLRGLAGAPGSANGGAHNCRPEAGMASVPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDSLVPNSSPLPTNGIGGSPESFPGPLDSSGHVGPEGSRLEHSENDKHSSKIPINAVRPHTSSPGLGKPPGPCLQSKAAVLQQLDRADETPGPPHPKGLPRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSPRPQSLDTTQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPEGHQRLVGPGCKAGPPQAEPLLPRAGFSPDSSRADSDAASSGGSDSKKKKRYRPRDYTVNLDGRVTEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRANSPIHTEQPRTELDKPEAKANLQSPFEQTNW
2) RQSSLLSSSGAQTPGAHHFMSEYLKQEESTRRGARTPHVLLPPGPPTDLPGLSRQVTQDDLDRIQAHQWP
61
464
449
533










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKKRYRPRDYTVNL
365
379