<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30437

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSASGPLQPKQSVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAQAPPLPQGPPGAPKPSSASQSSLVSTVAPGQGLAPSAQPGAPSMGGSVAPGGVSGPTAQLGPSSLGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLNPGANPQLRSLLLNPPPPQAGVPPPQAPLHHLQPPGAPPMLPPPHQGLGQPQLGPPLLHPPPTQSWSAQLPPRAPLPGQMLLSGAPRGAVPQPGLPPSVMEDDILMDLI
Length689
PositionUnknown
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.06
Grand average of hydropathy-0.208
Instability index55.29
Isoelectric point8.46
Molecular weight72672.65
Publications
PubMed=23258410

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     271.29|      66|      79|     238|     311|       2
---------------------------------------------------------------------------
  238-  294 (94.28/21.89)	........................PLQPKQSVPLPPAP.....PSGATLSA.....APQQPLPPV..PQQYQVPGNLSAAQVAAQNAVEAAKN
  295-  381 (87.71/28.05)	QKAGLGPrfspinplQQaapgvgpPFSQAQAPPLPQGPpgapkPSSASQSSlvstvAPGQGLAPS..AQ....PGAPSMGGSVAPGGVSGPTA
  553-  607 (89.30/21.32)	QQRGMGA........QQ.............APP.GLG......PILEDQ.A.....RPSQNLNPGanPQLRSLLLNPPPP....QAGVPPPQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.92|      30|     111|      39|      69|       3
---------------------------------------------------------------------------
   39-   69 (53.43/33.24)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  151-  183 (44.49/22.93)	YLLPAVESTTySGCTTES.LVQKIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.62|      17|      23|     631|     652|       4
---------------------------------------------------------------------------
  631-  647 (33.72/ 6.65)	PQLGPPLLHPPPTQSWS
  655-  671 (29.90/10.62)	PLPGQMLLSGAPRGAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.55|      19|      24|     457|     475|       5
---------------------------------------------------------------------------
  457-  475 (35.86/26.30)	LTTLGPLFR...N..SRMVQFHFT
  479-  502 (26.69/17.55)	LESLKGLYRimgNgfAGCVHFPHT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30437 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSASGPLQPKQSVPLPPAPPSGATLSAAPQQPLPPVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAAPGVGPPFSQAQAPPLPQGPPGAPKPSSASQSSLVSTVAPGQGLAPSAQPGAPSMGGSVAPGGVSGPTAQLGPSSLG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLNPGANPQLRSLLLNPPPPQAGVPPPQAPLHHLQPPGAPPMLPPPHQGLGQPQLGPPLLHPPPTQSWSAQLPPRAPLPGQMLLSGAPRGAVPQPGLPPSVMEDDILMD
233
543
389
687










Molecular Recognition Features






MoRF SequenceStartStop




NANANA