<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30430

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMGLGPGDNLIQWICEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQPLGGMGGLGAMGQPMSLSGQPPPGTSGMAPHGMTVVSTAAPQTQLQLQQVALQQQQQQQQQQQFQQQQVALQQQQQQQFQAQQNAMQQQFQAVVQQQQQQQQQLQQQQQQHLIKFHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQALQAQPPMQQPPMQQPQPPPSQTLPQQLQQMHHPQHHQPQPQPQQPPVAQNQPSQLPPQSQTQPLVSQAPALSGQMLYAQTQLKLVRAPMVVQQPQVQPQVQPQVQQQTAVPTAQAPQIVGSGVQMIAAALAQGGMQVRARFPPTTAVSAVPSSSIPLGGQPSAQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVLCARKRKFEEDERQSIPNVLQGEVARLDPKFLVSLDPSHCSNNGTVHLICKLDDKDLPSVPPLEFSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length774
PositionTail
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.03
Grand average of hydropathy-0.644
Instability index83.28
Isoelectric point9.39
Molecular weight84736.39
Publications
PubMed=23258410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30430
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     134.36|      21|      21|     217|     237|       4
---------------------------------------------------------------------------
  218-  239 (32.31/ 6.16)	NQQQIQQ..QQQLQ.RMAQLQLQqQ
  261-  283 (35.63/ 7.77)	PQPPPSQtlPQQLQ.QMHHPQHH.Q
  284-  306 (33.43/ 6.70)	PQPQPQQ..PPVAQnQPSQLPPQsQ
  340-  360 (32.99/ 6.48)	PQVQPQV..QPQVQ.QQTAVPTA.Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.35|      19|      21|      91|     111|       5
---------------------------------------------------------------------------
   91-  111 (33.78/20.18)	GMPSrgPGQPLGGMGGLGAMG
  113-  131 (37.56/16.81)	PMSL..SGQPPPGTSGMAPHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.76|      19|      21|     460|     479|       6
---------------------------------------------------------------------------
  460-  479 (36.39/13.75)	APSPSSFlPSPSPQPSQSPV
  481-  499 (34.37/10.07)	ARTPQNF.SVPSPGPLNTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.03|      10|      43|     405|     414|       8
---------------------------------------------------------------------------
  405-  414 (19.42/ 7.08)	GQPSAQVSQN
  445-  454 (20.61/ 8.00)	GQPSSQPNSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      13|      81|     248|     260|       9
---------------------------------------------------------------------------
  175-  187 (25.03/10.30)	QQQFQAQQNAMQQ
  248-  260 (27.94/12.88)	QAQPPMQQPPMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      28|     549|     575|      10
---------------------------------------------------------------------------
  540-  567 (35.23/20.64)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  572-  596 (39.17/15.50)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.29|      25|     283|     370|     398|      12
---------------------------------------------------------------------------
  370-  398 (31.78/30.29)	QMIAAALaQGgmQVrARFPPTTAVSAVPS
  658-  682 (45.51/24.85)	QSIPNVL.QG..EV.ARLDPKFLVSLDPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30430 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVQPQVQQQTAVPTAQAPQIVGSGVQMIAAALAQGGMQVRARFPPTTAVSAVPSSSIPLGGQPSAQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) KSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQPLGGMGGLGAMGQPMSLSGQPPPGTSGMAPHGMTVVSTAA
3) QQQQQQALQAQPPMQQPPMQQPQPPPSQTLPQQLQQMHHPQHHQPQPQPQQPPVAQNQPSQLPPQSQTQPLVSQAPALS
333
64
240
524
139
318










Molecular Recognition Features






MoRF SequenceStartStop




NANANA