<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30429

Description Mediator of RNA polymerase II transcription subunit 12 (Fragment)
SequenceQDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTFPDTGRRKPQVNQKDNFWLVTPRSQTAINTWFTDLAGTKPLTQLAKKVPIFNKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGTSSHSSHVMSAQSTSTLPTAPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPDGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEGADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPNSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKADVEKDVKPPAKEKLEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPILPLDPGDLTFLGGEDGQKRRRTRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMTQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGGGGRRQGGRNISVETASLDVYAKYVLRSICQQSPDGQLPQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDSEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGSTASHMPSGSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVTNWRDGQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVYQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEAGSFGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVGRGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKAEKPGAAPASTEERKKKSTKGKKRSQPAAKTEDYGVGPGRTGPYGVTVPPDLLHHANPGSIPHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPPRLPMQKLPARPPYPGVLPATMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLAQSSVHQMAPSSSYGLPTSQGYTPYVSHVGLQQHTGPASTMVPSSYSAQPYPSAHPAANPALADPARHLQQRPSGYVHQQAPTYGHGLASTQRFAHQTLQQTPMIGTLTPLGAQGVQAAIRSAPILPEQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAQGQPRRSGARPGDMALLDRGGRPDRTLSKGVGR
Length2236
PositionKinase
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.07
Grand average of hydropathy-0.377
Instability index50.62
Isoelectric point6.57
Molecular weight228484.47
Publications
PubMed=23258410

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30429
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     221.86|      65|     103|    1709|    1776|       1
---------------------------------------------------------------------------
 1730- 1833 (81.28/49.33)	EPPAPTLLePEKKAP.EPPKAEKPGAAPASTE.....ERKKKSTKGKKRSQPAaktedygvgpgrtgpygvtvppdllhhanpgsipHLSYRQGSigL...............................YTQNQPLpaGGP
 1836- 1939 (73.03/35.49)	DPYRPPRL.PMQKLPaRPP...YPGVLPATMTgvmglEPSSYKTSVYRQQQPA.............................vpqgqRLRQQLQA..KiqsqgmlaqssvhqmapsssyglptsqgytpYVSHVGL..QQH
 1940- 1987 (67.55/31.72)	TGPASTMV.PSSYSA.QPYPSAHPAANPALAD.....P...............................................arHLQQRPSG..Y...............................VHQQAP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.48|      31|     102|    1157|    1188|       2
---------------------------------------------------------------------------
 1054- 1072 (28.23/ 9.15)	CK..S...LSAEWLG..VLKALCCSS..........
 1157- 1187 (53.01/26.33)	CQ..SDGNKPTVGIRSSCDRHLLAAS...QNRIVDG
 1256- 1291 (50.24/24.41)	CQqsPDGQLPQEWVGERCLKSLCEDSndlQDPVLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     538.03|     172|     231|     185|     377|       7
---------------------------------------------------------------------------
  185-  377 (271.07/237.62)	GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEFLTWVLECFEkIRPGEDELLKLLLPLLL..RYSGE...FVQSAYLSRRLAYFCTRRLAlQLDGTSSHSShvMSAQSTSTlPTAPAPQPPTSSTPSTPfSDLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPLDHlPIAPSNLPMPD
  419-  612 (266.96/176.24)	GFTIGRVLHTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGRhraMVVAKLLEKRQAEIEAERCG.ESEGADEKGS..IASGSLSA.PSAPIFQDVLLQFLDTQ.APMLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAPGPR.PPSPFDDPADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.98|      32|     209|    1202|    1235|       8
---------------------------------------------------------------------------
 1202- 1235 (52.72/35.08)	AELKGS..GFTVTGGTEELpeEEGGG.GGGGRRQGGR
 1409- 1443 (46.27/24.36)	AKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30429 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKAEKPGAAPASTEERKKKSTKGKKRSQPAAKTEDYGVGPGRTGPYGVTVPPDLLHHANPGSIPHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPPRLPMQKLPARPPYPGVLPATMTGVM
2) EPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLAQSSVHQMAPSSSYGLP
3) FSPTMPCEGKGSPSPEKADVEKDVKPPAKEKLEGTLG
4) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPNSSV
5) TPYVSHVGLQQHTGPASTMVPSSYSAQPYPSAHPAANPALADPARHLQQRPSGYVHQQAPTYGHGLASTQRFAHQTLQQTPMIGTL
6) VQAAIRSAPILPEQXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXAQGQPRRSGARPGDMALLDRGGRPDRTLSKGVGR
1716
1869
656
596
1928
2021
1866
1922
692
643
2013
2236










Molecular Recognition Features






MoRF SequenceStartStop




NANANA