<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30428

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEKSQELSVQAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVVGAGGHITVGQQGLGSAKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHVGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVNCSCSRHKLLKRAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLDLQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNLESSDKWWHSFCLPRIDDAEFRPPELQGEKCDDKMEVNSESTALQRLLAQPNKRFKIWHDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETATALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHRVPAFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAVPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQVEGARKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGRVDEALVRSATVHAWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGCDKDFLTVSPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLADELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLASNSGSAAPTAGSAFNPTSNGSSTNPAASSSASGSSVPPVSSSASAPVVNQISTTSSSGFSGSVGGQNPSTGGSSADRTQGNIGCGGDPEPGQSASQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILITGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQMDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2195
PositionMiddle
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index57.82
Isoelectric point5.65
Molecular weight241194.35
Publications
PubMed=23258410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30428
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     764.66|     151|     156|     777|     927|       1
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  494-  638 (156.33/65.26)	.................LAGID.SSLEVSSSrkyDKQMAV.PSRNTSKQMNLNPMDSP....HSPISPLPPTLSPQPRGQETesldPPSVPVNPAlYGNG.LDLQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNLESSDKwwhsfclP....RIDDAEF..RPPELQgE
  640-  763 (156.75/65.45)	CDDKMevnSESTALQRLLAQPN.KRFKIWHD...KQ.PQMQPLHFLDPLP...LSQQPGDSLGEVNDPYTFEDGDIKYIFTA....NKKCKQGTE.KDSL.KKNK......................SEDGFGTKDVTTPGHSTPV.......PDgknAMSIFSSAT........
  777-  927 (246.71/107.36)	GSSSL...TQVTDLAPSLHDLD.NIFDNSDD...DELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPT....PPSLEQHPA.FSPV.MNYKDGISSETATALGMMESPMVSMVSTQLTEFKMEVEDGLGSPK.......PE...EIKDFSYVHRVPAFQ.P
  930- 1070 (204.88/87.88)	GSSMF...APL.KMLPSQCLLPlKIPDACLF...RPSWAVPPKIEQLPMPPAAT....FIRDGYNNVPSVGSLAD...........PDYLNTPQM.NTPVtLNSAAPASNSGAGVLPSPATPRFS.VPTPRTPRTPRTPRGGGTAS.......GQ..gSVKYDSTDQGSPAST.P
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     304.97|      94|    1264|     142|     362|       2
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  261-  362 (147.78/202.28)	VRMVYPSAFVLISqNDIPVPQSvVGAGGhiTVGQQG...LGSAKD..PSNCGMPLTPptSPEQAVIGESGGTQSAVSHvgSQDGGMITMHSPKRSGKIPPKLHNHMV
 1569- 1667 (157.19/46.07)	VPPVSSSASAPVV.NQISTTSS.SGFSG..SVGGQNpstGGSSADrtQGNIGCGGDP..EPGQSASQPSQDGQESVTE..RERIGIPTEPDSADSQAYPPAVVIYMV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1116|    1142|       3
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 1116- 1135 (40.30/33.55)	CICACNMNIK.GADVGLYIPD
 1146- 1166 (33.83/13.22)	CGFSAIMNRKlGYNSGLFLED
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.24|      27|      27|    1843|    1869|       4
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 1843- 1869 (47.30/37.24)	IALPNRSRRSKVS.ARKIGLQKLWEWCI
 1872- 1899 (42.93/32.91)	VQMTSLPWRVVIGrLGRLGHGELKDWSI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1264|     142|     175|       5
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  142-  175 (52.23/38.27)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1409- 1440 (59.04/34.64)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.29|      17|      17|    1218|    1234|       6
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 1218- 1234 (30.27/18.80)	TQPFASLSFLDYISSNN
 1237- 1253 (33.02/21.26)	TLPCVSWSYDRVQADNN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.85|      25|      26|      46|      70|       8
---------------------------------------------------------------------------
   10-   33 (23.09/ 8.69)	.....QAELTGI...........kWRRynfGGHGDCGPII
   46-   70 (49.11/26.62)	FIRCLQANLLCV............WRR...DVKPDCKELW
   72-  107 (33.65/15.96)	FWWGDEPNLVGVihhelqvveeglWEN...GLSYECRTL.
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.45|      18|      26|     446|     463|       9
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  446-  463 (29.71/24.44)	PASSKHKTAERQEKGDKL
  475-  492 (31.74/26.83)	PSVAEELCMEQDTPGQKL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      18|      26|    1324|    1341|      10
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 1324- 1341 (33.04/17.62)	KKRTGRTWENIQHVQGPL
 1347- 1364 (32.51/17.22)	HKMAGRGTYGSEESPEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.39|      19|      25|    1526|    1545|      11
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 1526- 1545 (29.20/20.48)	PGNAGPlASNSGSAAPTAGS
 1549- 1567 (32.19/17.98)	PTSNGS.STNPAASSSASGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.91|      15|      25|    1685|    1701|      12
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 1685- 1701 (22.32/18.33)	LLSLMRC.YteMLDNLPE
 1708- 1723 (22.59/11.61)	ILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.80|      58|    1645|     382|     444|      13
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  382-  444 (91.52/57.02)	STPtlEEEPANNPATWDFVDPTQRVNCSCSR.HKLLKRAvGPNRppTISQP...GFSAGPSSSSSLP
 2034- 2095 (92.28/43.99)	SSP..NSSPVPSPGSPSGIGVGSHFQHSRSQgERLLSRE.APEE..LKQQPlalGYFVSTAKAENLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30428 with Med13 domain of Kingdom Metazoa
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