<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30427
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQREEKQLEASLDALLSQVADLKNSLGSFIYKLENEYDRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRSNKQTFNPADTNALVAAVAFGKGLSNWRPSGSSGPGQPGQPGAGTILAGTSGLQQVQMTGAPSQQQSILSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQRISCPGSILAITQSYRQRGWDKLSSCSSGEVWACSSPILREANSALTWEIVTKSLSFILPYTDEERC |
Length | 334 |
Position | Head |
Organism | Pteropus alecto (Black flying fox) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae>
Pteropodinae> Pteropus.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.476 |
Instability index | 51.25 |
Isoelectric point | 6.16 |
Molecular weight | 36509.82 |
Publications | PubMed=23258410
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30427
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.58| 18| 39| 190| 207| 1
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190- 207 (38.06/17.12) GLSNWRPSGS........SG.....PGQPGQ
219- 249 (21.52/ 7.31) GLQQVQMTGApsqqqsilSGvqmaqAGQPGK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 76.18| 25| 28| 67| 92| 2
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67- 92 (40.28/27.55) KTPLFRNQViIP..LVLSPDRD.EDLMRQ
96- 123 (35.90/20.06) RVPVFSHEV.VPdhLRTKPDPEvEEQEKQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.71| 19| 20| 259| 277| 3
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259- 277 (34.80/19.31) KSASMHPYQRI.SC.PGSILA
280- 300 (26.91/13.64) QSYRQRGWDKLsSCsSGEVWA
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|