<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30413

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGCSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLLPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTNDDCPPIGTPVRDSSSSGHSQSTLFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTSHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGSDNGETKFKGNSQADTVDFSIIAVAGKALGSADLMEHHSGSQSPLLTTGDLGKSKGRQWHQ
Length973
PositionMiddle
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.06
Grand average of hydropathy-0.415
Instability index48.26
Isoelectric point5.75
Molecular weight106187.71
Publications
PubMed=23258410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30413
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     179.37|      48|      54|     354|     407|       1
---------------------------------------------------------------------------
  299-  340 (58.08/29.27)	.............LPA...CF...FLKFPQ.........PIPVSRAfvqkLQNCTGIPLFETQPTYVPLY
  357-  407 (81.99/60.56)	LN...HNMRfYAALPGQqhCY...FLNKDA.........PLPDGRS....LQGTLVSKITFQHPGRVPLI
  408-  457 (39.30/14.77)	LNlirHQVA.YNTLIGS..CVkrtILKEDSpgllqfevcPLSESR..........FS.VSFQHP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     577.68|     113|     340|     515|     627|       2
---------------------------------------------------------------------------
  515-  627 (190.53/95.87)	AETIQADTP..............ALS...LIAETVEDMVKKNLPPAS..S.PGYGMT.TGNNPMSGTTTPTNTFPGGPITTLFNMSMSI...KDRH..ESVGHGEDFS.KV.SQNPILTSLLQITGNGGSTIGSSPTPPHH
  632-  745 (139.71/68.27)	VSSMAGNTK..............NHP...MLM....NLLKDN..PAQdfS.TLYGCS.PLERQNSSSGSPRMEMCSGSNKTKKKKSSRLlpdKPKHqtEDDFQRELFSmDVdSQNPIF.D.VNMTADTLDTPHITPAPSQC
  746-  858 (128.10/61.95)	S.TPPTTYPqpvphpqpsiqrmvRLSssdSIGPDVTDILSDIAEEAS..KlPS...T.NDDCPPIGTPVRDSSSSGHSQSTLFDPDVFQ...TNNN..E...............NPYTDPADLIADAAGSPSSDSPT.SHF
  860-  950 (119.34/57.20)	...............................PDGV.DFNPDLLNSQS..Q.SGFGEEyFDESSQSGDNDDFKGFASQALNTL.GVPMLG...SDNG..ET.....KFK.GN.SQAD..TVDFSIIAVAGKALGSADLMEHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.41|      48|     161|      52|     108|       3
---------------------------------------------------------------------------
   52-  108 (65.36/68.12)	SGGH....QHLVSCLETLQKalKVTSlPAMTDRlESIARQNGLGSHLSASGtecyiTSDMF
  215-  266 (80.05/51.93)	SGGHlmnlKYYASPSDLLDD..KTTS.PIILHE.NNVPRSLGMNASVTIEG.....TSAMY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30413 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADLMEHHSGSQSPLLTTGDLGKSKGRQWHQ
2) DFSTLYGCSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLLPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTNDDCPPIGTPVRDSSSSGHSQSTLFDPDVFQTNNNENPYTDPADLIADAAGSPSSDSPTSHFFPDGVDFN
3) FNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKD
4) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGG
944
656
576
538
973
866
651
570










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFDES
2) RELFS
878
710
886
714