<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30412

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEKCGTLIRSIPTMLSVHSEQPHKTGFPTVHALVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACLVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKVFISIDECPYEPALQLGVSPLLDKADQRCNCDFTDFLLQECRKQGLLSEASVNNLMAKRAVDREHAPQPKAGENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSEESTKAAPVRALLFDISFLMLCHVAQTYGSEVIMSESSTGAEVPFFETWIQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMNWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMSSILEHMCADVLQQTATQIKFPSPGMDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYFSLFPLDDMQPSKLMRLLSSNEEDASSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length988
PositionTail
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.07
Grand average of hydropathy0.007
Instability index49.72
Isoelectric point6.28
Molecular weight109976.72
Publications
PubMed=23258410

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30412
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.04|      21|     115|     185|     206|       1
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  185-  206 (32.18/24.15)	EASSWTAIeHSLLK.LGEILANL
  304-  320 (24.62/12.76)	...KWTAF..TFLK.IPQVLVKL
  796-  814 (29.24/16.64)	DSSKW....HSLMDpPGTALAKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.25|      51|     115|     618|     672|       2
---------------------------------------------------------------------------
  618-  672 (75.78/67.68)	LAVCAVAWLVAHV..RMLGLDEREKSLQMIrQLagpLYSENTLQFYNERVVIMSSIL
  738-  790 (84.47/60.30)	LHMGGVYWFCNNLikELLKETRKEHTLRAV.EL...LYSIFCLDMQQVTLVLLGHIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.42|      15|     115|     264|     279|       3
---------------------------------------------------------------------------
  264-  279 (24.95/22.63)	VEQLMmVKRM...QHIPTP
  380-  397 (23.47/14.85)	VNNLM.AKRAvdrEHAPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.43|      54|      67|     483|     541|       4
---------------------------------------------------------------------------
  483-  541 (84.67/57.73)	ESTKAAPVRALLFDISFLMLChvaQTYGSEVIMSESSTGAEVpfFETWIQTCMPEEG..KI
  552-  607 (85.76/45.91)	DSTKVESLVALLNNSSEMKLV...QMNWHEACLSISAAILEI..LNAWENGVLAFESiqKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.54|      32|     249|      75|     126|       6
---------------------------------------------------------------------------
   91-  126 (51.52/55.99)	DLCVQALLDIMDMFCDrlsChGKAEECIGLCR..ALLS
  343-  376 (55.02/21.97)	QLGVSPLLDKADQRCN...C.DFTDFLLQECRkqGLLS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30412 with Med24 domain of Kingdom Metazoa
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