<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30410

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEVMISVTFCAWRRLDYHRAEFPVAGSFESLPKQWLTKDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQPTDPNLEWTHISTRYLREQLAKISDFYHVASSSGDGPVPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDSKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAEVAPPMIAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPIFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYPKDHDVKMEEQTIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANPSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEVRHQLKKITKDILKILNKKSTTETGVGDEGQKVRKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSVNYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNPGLGLFNPNGIGSTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNVSPGGSEENKRAYMNLVKKLKKELGDKQSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRMDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPASPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRADEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPAGPFVPTNTKQALSNMLQRRSGAIMQPPSLHAITSQQHLIQMKLLQQQQQQQQRLLRQAQARPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMSLQQTPQQQAGSVVLSPSYNSRTYPSAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLMGGGIDAVLTSAHPNLPSAPLPQDPMRPRQAQVRQQQRLLQMQQPPQQSSQPQSQTLSLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSKYPSSTPAHGSPETKKKQLYYLSRVHIPNPLQPASPRCQPAVWVYELNHPCA
Length2291
PositionKinase
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.07
Grand average of hydropathy-0.414
Instability index57.57
Isoelectric point8.07
Molecular weight256507.85
Publications
PubMed=23258410

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30410
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.69|      43|      43|     534|     576|       1
---------------------------------------------------------------------------
  534-  576 (88.44/63.20)	EVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
  578-  620 (89.26/63.86)	EVAPPMIAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     284.50|      33|      33|    2017|    2049|       2
---------------------------------------------------------------------------
 1903- 1943 (37.05/14.54)	P.............QS.NiyrvppnYS..PI.SSQmmhhP..QST..LWGYNLM...GQPQQ.PGF
 2017- 2048 (52.58/24.10)	..............QA.Q.......AR..PFQQGQ....P..GDQAALFAAQAR...PSPQL.PQY
 2049- 2081 (32.84/11.96)	P..........glqQA.Q.......TM..P..QGY....TmyGTQMSL...QQT...PQQQA.GSV
 2085- 2119 (38.87/15.66)	P.............SY.N.......SRtyPSAHSN....P..ALMERLRQMQQQ...PSGYV.QQQ
 2122- 2162 (24.27/ 6.68)	PylqpltgsqrlnhQSlQ.......QS..PLMGG........GIDAVLTSAH.......PNL.PSA
 2184- 2212 (44.06/18.86)	..............QM.Q.......QP..PQQSSQ....P..QSQT..LSLQAM....QPQQ.PLF
 2213- 2241 (28.61/ 9.35)	P............rQG..............LQQTQ....Q..QQQTAALVRQLQ.....KQLsSKY
 2242- 2274 (26.22/ 7.88)	P..........sstPA.H...............GS....P..ETKKKQLYYLSRvhiPNPLQ.PAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     446.27|     150|     201|     972|    1172|       3
---------------------------------------------------------------------------
  984- 1172 (227.49/305.97)	SSLAGsYTTGLCVCIVAVLrRYHSCL..ILNPDQTAQVFeGLCGVVKHVVNPSECSSPerC..............ILAYLYDLYVSCsHLRSKFGDLFS...SAC.............................SKVKQtiyNNVmpanSNLRWDPDFMMDFIENPSARSV.....NYSMLGKILSDNAANRYSFVCNTLMNVCmghqdagrindianfsseltacctvlSSEWLG..VLKA...LC
 1176- 1383 (218.78/169.81)	NHVWG.FNDVLCTVDVSDL.SFHDSLatFIAILIARQCF.SLEDVVQHVALPSLLAAA..CgdadaepgarmtcrLLLHLFRAPQAC.LLPQATGKPFPgirSSCdrhllaaahnsievgavfavlkaimmlgdAKIGN...NNV....SSLKNDDFTMRGLRRDGNADDIwtasqNSKSCGKSISIETANLREYARYVLRTIC..........................QQEWVGehCLKEperLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     191.93|      70|     191|    1403|    1533|       4
---------------------------------------------------------------------------
 1403- 1493 (95.26/193.22)	LQLICYpHGIKECTEG..DNLQRQhIKRILQNLE....................................QWTLRQSWLELQLMikqclkdpGSGSVaEMNNllDNiakatiEVFQQ.............SADLNNNSsnPG
 1586- 1706 (96.66/53.58)	LVLTCL.KGQDEQREGllTSLQNQ.VNQILSNWReeryqddikarqmmhealqlrlnlvggmfdtvqrstQWTTDWALLLLQII........TSGTV.DMHT..NN......ELFTTvldmlgvlingtlASDLSNVS..PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     330.51|     107|     123|     643|     759|       6
---------------------------------------------------------------------------
  627-  750 (166.99/114.58)	SEVLDEKESissaslaGSSLPIFQNVLLRFLDTQAPSLSDPNS.ECEKvefvnlvLLFCEFIR.......HDVFSHDAYMCTLISRGDLSVTASTRPRS....PAGENVDEhypKDHDVKMEEQTIMAHMGIDSGT
  751-  876 (163.52/92.98)	TNIFDEVDKsdfktdfGSEFPIFSPMPGESCENANPSLGRRMSvNGEK.......LLKREKPRelifpsnYDLLRHLQYATHFPIPLDESSSHECNQRTillyGVGKERDE...VRHQLKKITKDILKILNKKSTT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30410 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QMKLLQQQQQQQQRLLRQAQARPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMSLQQTPQQQAGSVVLSPSYNSRTYPSAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQRLNHQSLQQSPLMGGGIDAVLTSAHPNLPSAPLPQDPMRPRQAQVRQQQRLLQMQQPPQQSSQPQSQTLSLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSKYPSSTPAHGSPETKKKQLYYLSRVH
2) QPGFFLQNQSLTPGGSRLDPAGPFVPTNTKQALSNMLQRRSGAIMQPPSLHA
3) RSYYLEPLPLPPEEEEEEPASPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRADEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQP
2000
1940
1839
2265
1991
1938










Molecular Recognition Features






MoRF SequenceStartStop




1) TKKKQLYYLSRVHIPN
2) YLEPL
2253
1842
2268
1846