<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30409

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNLPAQRIVDDPDISRQREKIVKEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSTSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKHKNVKPRNPGQQGQALSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVVMDTDSASQRLVIPAPESQVRFSNIRTNDVAKTPQMHGSEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANVAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGHESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAVASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNNEREAGKKQKVEDGSSSVTVLSHEEDAMSLFSPSIKQDAPRPTGHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKLANGSDDKSNCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSMGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQCLPPIKLPEECVYRQSWTVGKLELLPSGPSMPFIKDGDGSTVDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLPDELILLLQDQCTNLFSPFGATDQDPFPKIGVISNWVRVEERDYCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILQMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLSYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVTMPSSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSSAVGSMSTQASTVQNGQVGGQQSSALQTAGISGESSSLPAQLHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLEPCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTADDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2059
PositionMiddle
OrganismPteropus alecto (Black flying fox)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Megachiroptera> Pteropodidae> Pteropodinae> Pteropus.
Aromaticity0.07
Grand average of hydropathy-0.409
Instability index51.09
Isoelectric point5.43
Molecular weight226567.18
Publications
PubMed=23258410

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30409
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1128.86|     298|     344|     642|     944|       1
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  165-  283 (78.43/34.62)	................................................SSCLK..EMSEEKQ..EDMDWeddSLAAVEVLVAGVRM..IYPACFVLV..PQSDIP..TP.......SSVG....SSHCST.SCLGVHQ.....VPASTRDPAMSsvtlTP..PTSPEEVQtvDPQSAQKWVKFSSvSDGFNSDSTS.................................................................................................................................................................................................................................................................................................
  360-  496 (66.81/28.41)	...............................................................................................................................................................................................................hhggkiprklanhvvdrvwqecnmnraqnkhknvkprnpgqqgqalslsqqqqvlpkhktnekqeksekpqkrpltPFHHRVSISDDVVMDTDsasqrLVIpapeSQVRFSNIRTNDVAK..TPqmhG...S.EM.ANSPQppplSPHPCDVVDEGVTKTPSTPQ.......SQHFYQM.PTPDPL..................................VPSKPV..............edrIDSLSQSFP..AQFQeaveptiyvgtavnLEEDEA
  513-  772 (339.05/195.45)	FLPP.qlPSDkFKD.....D.....PVG...PF..GHE.SVTSVTELMVQCKKPLKVSDELVqqY..................Q....IKNQYLSAVasDAEQEPKIDPyafvEGDEEFLFPDKKDRQNNeREAGKKQkvedgSSSVTVLSHEE....DAMSLFSPS.............................................................................................................ikqdaprPTGHARPPSTSLIYDSD.....LAV....SYTDLDNLFNSDEDE.lTP...G...SKKL.ANGSD....DKSNCKESKTGNLDPLSCIS.......TADLHKMYPTPPSLEQH..IMG.........FSPM.NMNNKEYGSMdTTPGGTV.................LEGNSSSMG..AQFK..............IEVDEG
  773- 1047 (408.48/228.56)	FCSPK..PSE.IKDFSYVYK.....PENCQVLV..GCS.MFAPLKTLPSQCLPPIKLPEECV..YRQSW...TVGKLELLPSGPSMPFIKDGDGSTV..DQEYGPAYTP....QTHTSFGMPPSSAPPSN.SGAGILP.....SPSTPRFPTPR....TPRTPRTPRGAG..GPASAQGSVKYEN.SDLYSPASTPSTCRPLNSvEP........................................................................................................................atVP...SipeAHSLyVNLIL....SESVMNLFKDCNFDS.CCICvcnmnikGADVGVYIPDPTQEAQYrcTCG.........FSAV..MNRK.FGN....NSGLF.................LEDELDIIGrnTDCG..............KEAEKR
 1048- 1215 (177.62/91.77)	FEALR..ATS.AEHVNGGLKeseklPDELILLLqdQCTnLFSPFGATDQDPFPKIGVISNWV..RVEER...DYCNDCYLALEHGRQFMDNMSGGKV..DEAL..VKSS....CLHPWSKRNDVSMQCSQ.DILQMLL.....SLQPVLQDAIQ....KKRTVR.PWGVQ..GPLTWQQFHKMAG.RGSYGTDESP.........EP......................................................................................................................................................................................................................................................................................
 1387- 1499 (58.48/24.32)	................................................................................................................................................PSATLASAAS....STMTMTS..GVT..MPS....SVATAN.STLTTASTSSSSSSNLNS.....................................................................................................................................................................................................gvssnklpsFPPFgSMNSSAVGSM.STQASTVqngqvggqqssalqtagISGESSSLP..AQLH..............PDVSE.
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30409 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLDNLFNSDEDELTPGSKKLANGSDDKSNCKESKT
2) GPSMPFIKDGDGSTVDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
3) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
4) RVWQECNMNRAQNKHKNVKPRNPGQQGQALSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVVMDTDSASQRLVIPAPESQVRFSNIRTNDVAKTPQMHGSEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDR
5) TSGVTMPSSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSSAVGSMSTQASTVQNGQVGGQQSSALQTAGISGESSSLPAQLHPDVSESTMDRDKVGIPTDGD
6) VAPTSQSLITPPQMTNTGNANTPSATLASAASSTMT
667
839
1906
300
1402
1365
701
924
1937
463
1514
1400










Molecular Recognition Features






MoRF SequenceStartStop




NANANA