<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30395

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISSIVFRVYEPSQEHAQTFPSAAADVETELRNRGHIVYYDATRRVLWYFHVPGKGATATDDNNGALGNTIEVEGATLLMVEDGSFEPVSLFKGRAPGQQAANTPTSSSSSNSALDLSLRNSRNTGSGPPSSSDPDSKPASAGGPDAKGTGSVPLKDAYEHFVTALLSTVSAAFCSRICAIPVNYRTVLFPAKVSRENQSDRALDSDSAVVGTFRIYLTTTGALVMSLSLSCCEGLLSVNEPSSPGQIVLGSQILAAPFGVLANYQGFMGGGLSYPELGLGQTPDTQLWRGADAKSSQWRDTCIKILQSRGLSPTLLQSCPWIALQMIRRKSGDGKSTPLPSTMATISWPAALCFRKKSVILARNHGLGDTALLAHEETADFLSEARTWFQLGTDREEKVTKRKKERETAATKETPAAVPPQQPNGHSPLGLRRASNAAAVGAMYPTPPDGVQNPLGITPSLDGTTSSPGAPNATVAIVDIDTAIADVTMPETAVPHTSQLNESYGDGGWNSNDNKPRADSFLGGESDNLFGDMGPDMFGDADITDADFSFFDEQPGDDLDLSGLPDMGMSDAPSMPPVLPPPLPEPAKMAAPPIEYTKPEPSPPIFTKPELKHARSTLMDEGKQRPSTEKAAGTKRESSPFGPDTVYKRVRASLGDIDSAPSRTPSRKGSVFDSVGFDPVLPSVNKKYEQGGRFDCNPVTRGLAQESITQPGSQGPPTTDYLRRHGKQRKQLKHSEQTSVVMRTITGGLENATLNTSPAKMDDFASDADDVSLVSDQDDASSTTDEPASPFKSSIRRLNFDDDVVSHVTSLKDIESVEDSDPTLALELPKLAKVEATEVSITKYFEDAEVLPIHLSLTDEDMVTIAQIVTEQAVTGNLKIRDSQANTLNTAIISETRRQLSSLSRTALQTLREVVPACLGEFNTCNFKGVVEVPDVPLLGQPNRLHPRPVPQRDSNAEPPKPNNLFQIPAPHMELRRAEARLSVLPSSVQFWESLGLGPAQGTKNVSVVCVFPNWDGMTDVAAAFLDRMRNVYELLKLGSFERLPTSSKVTDGLMPFEADKIATSPGTVSPHIGSSLDDRMEALNQGLLSANVMEKNFVVYFVYPPDHPGSIVEECTAFQRLFEMHKRSLTDRRQAPVNELVLQLVPLDFLTSPVGIVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKISNTSSSSVMHENTCMHIAYAQSIDERWITAAWTDNRGCQQMTASYSLGRKGKPLSTSLNDVYHEIWDTTHDLISKWKVHWRIIITKCGPMDQQEIGFWQGLAQTESMASMSLTLISVDTNPSLQLLPPAIKVPATASSAFYTTPVSTPQASILSPEQSGTPATPMKENNPVNAATPGGTPGDGNAEPAEGDAILLDVTDQTWGAVLAHRLSNSSTLGELSPAIISGYLVKRGGTKLEDPPVVLEVNILHVDSNPRLCETLMREMLTYFRGLGTLARARGIVDRGTDIRPWHIAAAEKGVRALYLLM
Length1523
PositionKinase
OrganismColletotrichum fructicola (strain Nara gc5) (Anthracnose fungus) (Colletotrichum gloeosporioides (strain Nara gc5))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.06
Grand average of hydropathy-0.332
Instability index49.75
Isoelectric point5.10
Molecular weight164439.17
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30395
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      13|      15|     680|     693|       1
---------------------------------------------------------------------------
  680-  693 (20.05/16.59)	PSRKGSvFDSVG.FD
  697-  710 (20.46/11.41)	PSVNKK.YEQGGrFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     340.23|      83|     359|     583|     665|       2
---------------------------------------------------------------------------
  474-  551 (92.39/35.25)	.....PSLD....G..TTSSPGAPNATVAIVDIDTaiadvTMPE.....TAVPHTSQLNESYGDGG.WNSNDNKPRADSFLGGESDNlfGDMGPD......
  583-  665 (148.40/60.77)	GMSDAPSMP....P..VLPPPLPEPAKMAAPPIEY.....TKPE.....PSPPIFTKPELKHARSTLMDEGKQRPSTEKAAGTKRES..SPFGPDTVYKRV
  944- 1021 (99.44/38.46)	GVVEVPDVPllgqPnrLHPRPVPQRDSNAEPP.........KPNnlfqiPAPHM....ELRRAEARL....SVLPSSVQF....WES..LGLGPAQGTKNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     252.99|      78|     393|     725|     805|       3
---------------------------------------------------------------------------
  725-  805 (122.28/93.94)	QPGSQGPPTTDYLRRHGKQRKQLKHSEQTSVvmRTITGGLENATLNTSPAKMDDfASDADDVSLVSDQDDASSTTDEP.ASP
 1123- 1201 (130.71/88.78)	HPGSIVEECTAFQRLFEMHKRSLTDRRQAPV..NELVLQLVPLDFLTSPVGIVE.PTPSDAIKLAIETYDRCTLFGGPmPSP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30395 with Med13 domain of Kingdom Fungi
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