<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30391

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGQNGTHSNHDRNLKMNGINGTPMDGQPSPNKGKAPVEASSNLANGVPADSGKQQSQMNTGLTLQPKSRMNDLPEEIVHITQGYIPLSMIVSRLAQRTHEDLQKVIMEMAAVKWAPPAVNGNTPQGNEAPDDMSEGNKRKKMLMLKFAQDAHAKWVKALVITDWSRNAEAVSKLIDIKAHIDSKRMLYDYAQDLLIDLKRGLNGARLPNPDLKTALQVLTTGEASWVPEPGYIPPPPLTPEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKTYSIHSGRVTFKVKGEFEVDLTIADEDFTKQFWFIDFRFAFSPSAKKLSDGLVSFLEGQVNEILGKDGLEGCYRFLHEFVLTHKINELKRQALELSRSTWTGTLMVEPLNRALALQYWTTRYGPNGPKSWVMVAVNSAKKTNGQLDPKQSSRLVARWYRDNKEVKDVLLPFDVDTLCAEDLLKTAVARHVEHILSSIHSKLLSYPRFANRESSMTLKVSKKEPVESFLSMQLSPRENVILVVEPVTGFAAIQPHTKYTLSGETRLNYGQKDPAEDGVVCLESIRWGYVMEEFNRRGRSVGWKTCKSPLSNEDIKQLIRTREAFQTVFLQRQSLDEDWHVMASLSLAGDEWWLIQIDRNTPARPIKFSCRLRLNHGQPDLDDSFWSNLTTFVTGTISHVTDLQNLHTNRIKYVMRESTNYSLPQQVRMPSILLKLSQILRHSHLGGHYGANDASDESDKYAPSWAQNHVEIKFKGLQPQVPAALGKDDKGASPVDVIDNCKINTVVDAIIRVKDRSKFTLLKGRIDRDVSFSPRKGEFIFRIRQTVGHPILDILTSHVKSIDRLVGFLEAIGKARGSLKCERMSLRQVIFTYGDVAMPGESDATAKPRRWRATLDLARSDIRISLERGNPHLRMLDLFTTMVNTQAGLKALIIYMPLMLPVLKTVESIESKWEALESTNQGRVEVFPRAVDWVAIRYTLTSPSGQSRVLSVDVRSKIRRHESWFHVQRVTGGESFGPDEEFNKLLKGIWESHGDGWRGLTTAAASRPGPSIMDLLTKLDDAVRTHAATGGNGPPSSDGAATQFRQTFSANQSFGTQPTSVSQGSNRTSGSKQAPLVLD
Length1111
PositionTail
OrganismColletotrichum fructicola (strain Nara gc5) (Anthracnose fungus) (Colletotrichum gloeosporioides (strain Nara gc5))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.07
Grand average of hydropathy-0.442
Instability index39.20
Isoelectric point9.01
Molecular weight124681.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30391
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.20|      38|     151|     638|     683|       1
---------------------------------------------------------------------------
  646-  683 (69.58/65.40)	LNHGQPDLDDSFWSNLTTF...VTGTISH.VTDLQNLHTNRI
  793-  834 (54.62/32.83)	LLKGRIDRDVSFSPRKGEFifrIRQTVGHpILDILTSHVKSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.39|      13|     151|     286|     304|       2
---------------------------------------------------------------------------
  291-  304 (19.37/29.04)	FEVDlTIADEDFTK
  445-  457 (24.02/11.54)	FDVD.TLCAEDLLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.25|      29|     505|     324|     357|       3
---------------------------------------------------------------------------
  324-  357 (49.40/41.12)	DGLVSFLEGqvneiLGK.DGLEGCYRF.LHEFVLTH
  835-  865 (43.85/26.15)	DRLVGFLEA.....IGKaRGSLKCERMsLRQVIFTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.88|      24|     151|      60|      89|       4
---------------------------------------------------------------------------
   60-   89 (38.42/38.78)	QMNTGLTLQPKSRMNDLPEeivhitQGYIP
  214-  237 (43.46/28.77)	DLKTALQVLTTGEASWVPE......PGYIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.85|      21|     694|     188|     210|      12
---------------------------------------------------------------------------
  188-  210 (33.59/28.27)	RMLYDYAQ.DLLIDLKRGlnGARL
  884-  905 (32.27/20.09)	RATLDLARsDIRISLERG..NPHL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30391 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGGQNGTHSNHDRNLKMNGINGTPMDGQPSPNKGKAPVEASSNLANGVPADSGKQQSQMNTGLTLQPKSRMNDLPEE
2) VRTHAATGGNGPPSSDGAATQFRQTFSANQSFGTQPTSVSQGSNRTSGSKQAPLVLD
1
1055
79
1111










Molecular Recognition Features






MoRF SequenceStartStop




NANANA