<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30386

Description RNA polymerase i activation mediator protein
SequenceMGVQPRPPQQRTLSSSGLSVQRPTHQRTLSQQYLPQSPVRKENLIDLTGADNDAAVAQNRYGTLPRRGGSRLKLELSNDAMLPQHHPSDSPNILTPNHPPDAQDRARKPHRHELAGLRKRPTHRHSPAPVVAVKKDGRPKPYHLETPAAAPRYAPFGKPRSDATAKQGFGAGGGARDSQDLGHADFFPWTGNHPEDQWSETIIKNGYFDKPPATTAETTSAKAALFPALKHKTGLNLLSNIFTGILNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRSVKRKGTGPNGPFVVTGEAKWLRDWTVFVEQFVEGVSTAFGDNDWKAKVQYAIRLATHLYAEQLLERDHYMDWLVSGLENSTQAKLPMWILITQIYWKDLLRLRRYGRRLVNALLGHLNTIHNDPDRDILIQLTMRLTSLLIPLVSSHPDNFVAPATWFKYRDALLASIPIDNDFAQTAFKSINSRNEQLCWIVSEDKSMIVRTLLEWCTSPHRPGAAKVYITASLLRAWIPTGLDVTTAILEFLSKCPPTEPNAKKTFHMLVSEIARSGDFQFQGYVFWLIARGGLREPSDTEREGSCATRLLVDLPLHALDPASLATRASLLRRATYDVNDEAEDINTALKCIQHAMGLPLPPGDPILQRKPVSLGKLCRLISNSNRALQTEVGARLLQIFTTETVMTKNGPQVSVPMFNFARAVLEAASDFSVLAEIVKVVIRVSNPEILASCADTVNVHLPIFAALGVGKELFDVLLERLKVVGEEQGVAARPLLASLANLAARLPGLTNTATHLRKELHQCDRNTAIDACSPVSDNMAGRLQDTEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVSRLESSWSNSPERQRAYSALLGRLRIFDTQHFDLRMTDWVHHVSALKSRPGLADIYPLLISIGCLTLPILLTTTTVDSSSVARNPAAPVNSTTTYMQEVLSLCVMPLTLKTALTPEETYRFYIQQKVAPRQNHKDMVILVRNALVEYARLQSQPGISLPLSNSACGDNMLELLKLLVLLDAPSVVQSLGTKTADPALSGLFAQITTKLLMPGAQDGTPLSFETVLELANEFTLPFCQLKLSIGLPADTTTSPGGGEQAMSQFDMFSRAMDRAVSANNVMWTSMLPYLNEEVTEHLKRQAHLRFLGLFPSQKNPSASDPLSQDSIQLAGSLLSVVEAIVRGRPAPRTSQLTSGMVEKLSELWEILAAGGDGKRELRASILRHWLPALLKFITLHTNANEAAPVPAQGANMKPPTSTTAFEIRGRILIVLAGLTLELDGLALEEPQTGRPLSQQVFDLALLLVDCLPDDTRLQCVRVLLTNGTPQNPASSDARLRYLFSQMAPPTDQFVLAHRQQPTTQQAGPPRLKVPISMQGTDKLTPFTYRRWEMLSEPTPNIGENDTALSLTLFEAIKIQ
Length1473
PositionKinase
OrganismColletotrichum fructicola (strain Nara gc5) (Anthracnose fungus) (Colletotrichum gloeosporioides (strain Nara gc5))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.06
Grand average of hydropathy-0.222
Instability index43.12
Isoelectric point8.96
Molecular weight162833.06
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30386
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     246.72|      81|      95|      17|     101|       1
---------------------------------------------------------------------------
   17-   64 (56.16/33.50)	.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLSVQRPTHQRTLSQQYLPQSPVRKENLIDLTGADNDAAvaQNRYGTL
   65-  156 (124.73/79.96)	PRRGGS.RLKLELSNDAMLPQH..HPSDSPniLTPNHPPD.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................aqdrarkphrhelaGLR.KRPTHRHSPA....PVVAVKKDGRPKPYHLETPAA..APRYAPF
  159-  196 (35.96/14.88)	PRSDATaKQGFGAGGGARDSQDlgHADFFP..WTGNHPED.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1338- 1372 (29.87/10.30)	........................................qwsetiikngyfdkppattaettsakaalfpalkhktglnllsniftgilnqrklngqisspstfkppprvtltdtkremwlrdlanpsislrrlsrtiphgirgkvlldhclnknvpteravwlvkcvganeirsvkrkgtgpngpfvvtgeakwlrdwtvfveqfvegvstafgdndwkakvqyairlathlyaeqllerdhymdwlvsglenstqaklpmwilitqiywkdllrlrrygrrlvnallghlntihndpdrdiliqltmrltslliplvsshpdnfvapatwfkyrdallasipidndfaqtafksinsrneqlcwivsedksmivrtllewctsphrpgaakvyitasllrawiptgldvttaileflskcpptepnakktfhmlvseiarsgdfqfqgyvfwliargglrepsdteregscatrllvdlplhaldpaslatrasllrratydvndeaedintalkciqhamglplppgdpilqrkpvslgklcrlisnsnralqtevgarllqifttetvmtkngpqvsvpmfnfaravleaasdfsvlaeivkvvirvsnpeilascadtvnvhlpifaalgvgkelfdvllerlkvvgeeqgvaarpllaslanlaarlpgltntathlrkelhqcdrntaidacspvsdnmagrlqdtegelheeieklltsgtsvdrptmdrlfqtvvsrlesswsnsperqraysallgrlrifdtqhfdlrmtdwvhhvsalksrpgladiypllisigcltlpillttttvdsssvarnpaapvnstttymqevlslcvmpltlktaltpeetyrfyiqqkvaprqnhkdmvilvrnalveyarlqsqpgislplsnsacgdnmlellkllvlldapsvvqslgtktadpalsglfaqittkllmpgaqdgtplsfetvlelaneftlpfcqlklsiglpadtttspgggeqamsqfdmfsramdravsannvmwtsmlpylneevtehlkrqahlrflglfpsqknpsasdplsqdsiqlagsllsvveaivrgrpaprtsqltsgmveklselweilaaggdgkrelrasilrhwlpallkfitlhtnaneaapvpaqganmkpptsttafeirgrilivlagltleldGLALEEPQTGRPLSQQVFDLALLLVDCLPDDTRLQ.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     247.19|      84|     102|    1100|    1195|       2
---------------------------------------------------------------------------
 1100- 1195 (119.30/112.98)	GLFAqiTTKllMPGAQDgtPLSFETVlELANEFtLPFCQlKLSIGLPADTTTS.PGGGEQAMSQ.FDMFSRAMD..RAVSANNV.MWtsmLPYLNEEVTEH
 1206- 1294 (127.89/81.41)	GLFP..SQK..NPSASD..PLSQDSI.QLAGSL.LSVVE.AIVRGRPAPRTSQlTSGMVEKLSElWEILAAGGDgkRELRASILrHW...LPALLKFITLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.38|      49|     101|     528|     584|       3
---------------------------------------------------------------------------
  528-  584 (79.68/60.43)	DKSMIVRTLLEWctsP.HRPGAAKVYITASLLRAWI....PTGLDVTTAIleflsKC.........PPTEP
  627-  689 (68.70/36.51)	EGSCATRLLVDL...PlHALDPASLATRASLLRRATydvnDEAEDINTAL.....KCiqhamglplPPGDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.42|      34|     101|     947|     982|       4
---------------------------------------------------------------------------
  947-  982 (53.49/43.26)	LKSRPGLAdiYPLLISI.GCLTLPILLTTTTVDSSSV
 1051- 1085 (52.93/35.68)	LQSQPGIS..LPLSNSAcGDNMLELLKLLVLLDAPSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.63|      23|     101|     387|     421|       6
---------------------------------------------------------------------------
  387-  409 (41.99/46.25)	ATHLYAEQLLERDHYMDWLVSGL
  423-  445 (40.64/18.34)	ITQIYWKDLLRLRRYGRRLVNAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30386 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGVQPRPPQQRTLSSSGLSVQRPTHQRTLSQQYLPQSPVRKENLIDLTGADNDAAVAQNRYGTLPRRGGSRLKLELSNDAMLPQHHPSDSPNILTPNHPPDAQDRARKPHRHELAGLRKRPTHRHSPAPVVAVKKDGRPKPYHLETPAAAPRYAPFGKPRSDATAKQGFGAGGGARDSQDLGHADFFPWT
1
190










Molecular Recognition Features






MoRF SequenceStartStop




1) FTYRRW
2) GLRKRP
3) KPYHLETPA
1440
116
140
1445
121
148