<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30385

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVIRGVQRAALKQWNEFIAKSLATRLDPDKFESYVPFLQAKHPLPPSVVADLFLRPQPHNHESLDPRVPRFLQVLSDLNYIDTPSILEALYKYSTSRAHSREAAQASNGGNPTSQTLRWASSYSAEEVMFYRLTKSVAQGTAIPNTETGLAIAKIMASWIALFTDAATAFTVDVMGQLQNSQAREEMESARAAFVALLLGVCENHTVMKAFGSPEAKNTRKALSESLANFVPTIMQNAGPIATRLDMFRTSTLAAFEPVDEQKNTSNVEIEDLFDSSVALENFVISELPIVNSRAGLYIYLNAALVGRPLIDDMSIFNYLNNRYQGDVQTTTIDLILASFDVLANAVSRNEGNSAAPLLRSFLMNKLPLLIENLSKHMYPPLTAEFCITEALGRVDTNTFPTLSSMFDESRSNNPFTDSVREEFCWACCLHGLVRESSIEGLLGETPYQNLPAGGRYVKDNLVAECLADPERMQALIGELDGKDGNAGAVCQALTEVLGQLCRNKETMSLKLLCSQLAQKPLSLDVMLLFEKPATILHPLCDLLDNWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYNLSVSDLGIVSPDSFVSKLLGQGHQSRVFDELSEQQKGHLDGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQNIVLAFSTGHLSEESLRGGVEYLVDTFLLPSLVVAITYLSNSLLIERSECQKAIVRVLKSVLEPTSISKEASDMLSSVMNIVAKPLEHSLRTYQRSDPKSQEIEPLLRAIKDSIPLSRRTGAADHVELEAWSGVQQHQHNHQNVGFANTLRQTLQSLVQWSIHPAMDRPPPTYTHRQILVALIILGAKRLLQLIYEDIRQHSEAGSGSIVYDVAANLVCAPDANDSPWANALNFMDNSGNMPAPIQKKLTMREVLKSDAENCKRLQKTDMNLAEIVVRLHRKVESQMVVAQAAAIQADTMLQNDLGLGLDGGTGSLDDAMAAATANVVAGDGMSVDNVSLGDMGLGGPSNAGGGLDLGDNDLFSGLDTGDDFQWDNMDLS
Length1037
PositionTail
OrganismColletotrichum fructicola (strain Nara gc5) (Anthracnose fungus) (Colletotrichum gloeosporioides (strain Nara gc5))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum gloeosporioides species complex.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index43.16
Isoelectric point4.86
Molecular weight113826.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30385
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.29|      13|      17|     292|     305|       1
---------------------------------------------------------------------------
  292-  305 (19.18/16.21)	PIVNSRaGLYIYLN
  312-  324 (24.11/15.28)	PLIDDM.SIFNYLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.43|      21|     349|     259|     279|       2
---------------------------------------------------------------------------
  259-  279 (37.36/20.59)	FEPVDE.QKNTSNVEIEDLFDS
  609-  630 (36.07/19.67)	FDELSEqQKGHLDGWIHGLFDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.32|      15|      15|     672|     686|       3
---------------------------------------------------------------------------
  672-  686 (25.11/14.07)	SLRGGVEYLVDTFLL
  688-  702 (23.21/12.53)	SLVVAITYLSNSLLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.30|      16|     322|     172|     190|       4
---------------------------------------------------------------------------
  172-  190 (20.11/22.42)	AFTvDVMGQLqnSQAREEM
  496-  511 (29.20/17.85)	ALT.EVLGQL..CRNKETM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.14|      15|      15|     743|     757|       5
---------------------------------------------------------------------------
  743-  757 (26.94/13.57)	LEHSLRTYQRSDPKS
  760-  774 (25.20/12.33)	IEPLLRAIKDSIPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.23|      18|     323|      25|      47|       6
---------------------------------------------------------------------------
   25-   42 (34.51/28.75)	LATRLDPDKFESY...VP.FLQ
   55-   76 (26.72/ 9.54)	LFLRPQPHNHESLdprVPrFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.25|      12|      15|     709|     720|       7
---------------------------------------------------------------------------
  709-  720 (17.55/10.26)	KAIVRVLKSVLE
  726-  737 (19.70/12.36)	KEASDMLSSVMN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30385 with Med5 domain of Kingdom Fungi
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