<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30379
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MPEDSSMEVPVNLAVDCVVRNAMEKLVEKQADLRNKSFQRKKELAKYFEETRRQLISLLALVRWQKKRLKVTKQCDDLIENLRLHHWHMHTTSERLCIASEELAYQHRTPMYDMRTAVDVLASGTYNGLPDMEMQKIITPKVTDAEKEQVIKRLDFLIRTELLNMKIPADLSKVEVKDGRLTLQADDEFELVLSLRLDQSPHPFKVDKVQLLVKAQGGPLPACDGLVPLIENRMMHNQEPLVEAVTILGDCARFRTWQILNSQAQGPLFSPKVDVETSTNGNSFTVYYWQDSQAPVSFESLMTSAVRKNTVETKANVSADSRIKIKNPCIIFMSTKEGHSRVQIKHSPPLVDEDGKIVEIHVNRSSLSLESVIQDVLKLHSSCRLRLLHKRLSEYECLLRDCDIAVTMTPTGNELVVHVEGKPRVSIVSDYKSGELEARDLLLTDSAPTYEKLQTGLHRALLRTGDDSVAQVLIAWRSYDILNIVTGLAPSFGLKPAFKLLTYSHSQSIQLNDLVNEKKPGIFLQLPGCSILDSGYKDPSKPLPKPSSQDVWALMVQYDAYEGKFHFSLLILSVSKGAKPVIEKLDVDKIPLQSWPPASSQNQEPRTKKRKVTGPIETSSVEKIARIQLAKVSEIVSKRIRFMQLEKQLDMQRIKWRSVGDVILLHLHASLLQSRELRLYLEPKSASFVAGGCSGWKAEMTITTSYHEHYKHPSEILPTIKRVGFLEEVVEEGGSNTLTLNFPNIHCESIRMLQQIVQGLSHIARLAHRIMEIFDPAHSEEYKDLQGTLAIEAMGHTCIVLRMIESRQLISIRYRLRGGFAVSIGNEVHPLTGNAEIALDSEQDIVDILTSIVSMQVLLDIVKELPTNPGDVTLFSHHLDGLCVIFRGMFGFYIRYTDIYSISDATVCTPRFASKGMVEQDEWSYKFPPTSFSSFMDTIWPIPDWQNVISFIVDHITALDYNSLLAEGQNVLVPEREQGYLPPIPHFTGKSSSLVCSRAHVQKTIELAYQHIVVSFMHIYGNWLISKVNTSTTNRIAPAPPAQSAPPAPPAPPAHPASAPSTFIVRGRHIFSLELTQKGMPQWNGVEKLRLKVENAGAAAEKTKETLTDADVKTIESIFEEAINESCSMNRLRSFLNLLSFPVAVIHSFCEIWREISIMYKQVAEVALAPVFLVDTAETKEKVAAGIRKGALTPSPRSDSVSCILHDNTKDEATFVLRLWMNETPAVEVQLIYAYTQSKMFSGTITVLPVGSSREASATEMAETILKLTANPTPVPAGQLWSSVKNILGQFQAPPPPAPAI |
Length | 1301 |
Position | Tail |
Organism | Guillardia theta (strain CCMP2712) (Cryptophyte) |
Kingdom | Cryptophyta |
Lineage | Eukaryota> Cryptophyceae> Pyrenomonadales> Geminigeraceae> Guillardia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.166 |
Instability index | 47.63 |
Isoelectric point | 6.65 |
Molecular weight | 145795.39 |
Publications | PubMed=23201678
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30379
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.17| 11| 17| 321| 331| 1
---------------------------------------------------------------------------
321- 331 (20.76/12.90) SRIKIK.NPCII
340- 351 (15.40/ 7.55) SRVQIKhSPPLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.35| 14| 17| 617| 631| 2
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617- 631 (17.72/14.99) ETSSvEKIARIQLAK
634- 647 (23.63/15.00) EIVS.KRIRFMQLEK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.11| 10| 16| 518| 527| 4
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518- 527 (18.57/10.15) KKPGIFLQLP
537- 546 (19.54/11.11) KDPSKPLPKP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.93| 20| 24| 38| 61| 5
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38- 61 (26.60/27.17) FQRKK.ELAKYFEEtrrqLISLLAL
64- 84 (31.33/20.07) WQKKRlKVTKQCDD....LIENLRL
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