<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30379

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPEDSSMEVPVNLAVDCVVRNAMEKLVEKQADLRNKSFQRKKELAKYFEETRRQLISLLALVRWQKKRLKVTKQCDDLIENLRLHHWHMHTTSERLCIASEELAYQHRTPMYDMRTAVDVLASGTYNGLPDMEMQKIITPKVTDAEKEQVIKRLDFLIRTELLNMKIPADLSKVEVKDGRLTLQADDEFELVLSLRLDQSPHPFKVDKVQLLVKAQGGPLPACDGLVPLIENRMMHNQEPLVEAVTILGDCARFRTWQILNSQAQGPLFSPKVDVETSTNGNSFTVYYWQDSQAPVSFESLMTSAVRKNTVETKANVSADSRIKIKNPCIIFMSTKEGHSRVQIKHSPPLVDEDGKIVEIHVNRSSLSLESVIQDVLKLHSSCRLRLLHKRLSEYECLLRDCDIAVTMTPTGNELVVHVEGKPRVSIVSDYKSGELEARDLLLTDSAPTYEKLQTGLHRALLRTGDDSVAQVLIAWRSYDILNIVTGLAPSFGLKPAFKLLTYSHSQSIQLNDLVNEKKPGIFLQLPGCSILDSGYKDPSKPLPKPSSQDVWALMVQYDAYEGKFHFSLLILSVSKGAKPVIEKLDVDKIPLQSWPPASSQNQEPRTKKRKVTGPIETSSVEKIARIQLAKVSEIVSKRIRFMQLEKQLDMQRIKWRSVGDVILLHLHASLLQSRELRLYLEPKSASFVAGGCSGWKAEMTITTSYHEHYKHPSEILPTIKRVGFLEEVVEEGGSNTLTLNFPNIHCESIRMLQQIVQGLSHIARLAHRIMEIFDPAHSEEYKDLQGTLAIEAMGHTCIVLRMIESRQLISIRYRLRGGFAVSIGNEVHPLTGNAEIALDSEQDIVDILTSIVSMQVLLDIVKELPTNPGDVTLFSHHLDGLCVIFRGMFGFYIRYTDIYSISDATVCTPRFASKGMVEQDEWSYKFPPTSFSSFMDTIWPIPDWQNVISFIVDHITALDYNSLLAEGQNVLVPEREQGYLPPIPHFTGKSSSLVCSRAHVQKTIELAYQHIVVSFMHIYGNWLISKVNTSTTNRIAPAPPAQSAPPAPPAPPAHPASAPSTFIVRGRHIFSLELTQKGMPQWNGVEKLRLKVENAGAAAEKTKETLTDADVKTIESIFEEAINESCSMNRLRSFLNLLSFPVAVIHSFCEIWREISIMYKQVAEVALAPVFLVDTAETKEKVAAGIRKGALTPSPRSDSVSCILHDNTKDEATFVLRLWMNETPAVEVQLIYAYTQSKMFSGTITVLPVGSSREASATEMAETILKLTANPTPVPAGQLWSSVKNILGQFQAPPPPAPAI
Length1301
PositionTail
OrganismGuillardia theta (strain CCMP2712) (Cryptophyte)
KingdomCryptophyta
LineageEukaryota> Cryptophyceae> Pyrenomonadales> Geminigeraceae> Guillardia.
Aromaticity0.07
Grand average of hydropathy-0.166
Instability index47.63
Isoelectric point6.65
Molecular weight145795.39
Publications
PubMed=23201678

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30379
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.17|      11|      17|     321|     331|       1
---------------------------------------------------------------------------
  321-  331 (20.76/12.90)	SRIKIK.NPCII
  340-  351 (15.40/ 7.55)	SRVQIKhSPPLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.35|      14|      17|     617|     631|       2
---------------------------------------------------------------------------
  617-  631 (17.72/14.99)	ETSSvEKIARIQLAK
  634-  647 (23.63/15.00)	EIVS.KRIRFMQLEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.11|      10|      16|     518|     527|       4
---------------------------------------------------------------------------
  518-  527 (18.57/10.15)	KKPGIFLQLP
  537-  546 (19.54/11.11)	KDPSKPLPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.93|      20|      24|      38|      61|       5
---------------------------------------------------------------------------
   38-   61 (26.60/27.17)	FQRKK.ELAKYFEEtrrqLISLLAL
   64-   84 (31.33/20.07)	WQKKRlKVTKQCDD....LIENLRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30379 with Med14 domain of Kingdom Cryptophyta
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