<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30376
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MAEEFYFVNHSSYSQTIPSVTEDLQCLYGLNELAKRVARVDEFGNKRKMRQSYKGHIQHLPEACWIGENVILKDRFIRDLILKPQEDKTNKFIEDLDPEMLEMAFTLQPEPVSHLDSNILEYGSLEKDELYDNKDRESTRSINDTKRYSKKKRKHDEYELFSDSGQKKKYKKTS |
Length | 174 |
Position | Head |
Organism | Pneumocystis jirovecii (strain SE8) (Human pneumocystis pneumonia agent) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina>
Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -1.014 |
Instability index | 66.29 |
Isoelectric point | 6.24 |
Molecular weight | 20620.99 |
Publications | PubMed=23269827
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30376
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 46.00| 14| 16| 124| 137| 2
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124- 137 (23.06/14.50) SLEKDELYDNKDRE
141- 154 (22.94/14.39) SINDTKRYSKKKRK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 34.63| 10| 17| 93| 102| 4
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93- 102 (17.79/ 9.99) IEDLDPEMLE
112- 121 (16.84/ 9.18) VSHLDSNILE
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|