<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30369

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASTGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAIIGESGGTQNAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNLATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDPPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNSESSDKWWHSYHLPSIDDVEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPEGKNAMSLFSSTKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFRMEVEDGLGSPKPEEIKDFSYVHKVPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPTATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFSQPWGSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSNLLIPPKYQTPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGSSTNTAASSSASGSSVPPASSSASAPIISQISTTSSSGFSGSVGGQNPSTGASSSERTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHPSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2209
PositionMiddle
OrganismSus scrofa (Pig)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Suina> Suidae> Sus.
Aromaticity0.07
Grand average of hydropathy-0.383
Instability index58.03
Isoelectric point5.65
Molecular weight242841.08
Publications
PubMed=30723633

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30369
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.87|      27|      28|    1008|    1034|       1
---------------------------------------------------------------------------
 1008- 1034 (48.71/29.82)	PDYLNTPQMNTPVTLNSAAPASNSGAG
 1039- 1062 (44.66/26.51)	P...ATPRFSVPTPRTPRTPRTPRGGG
 1078- 1096 (26.51/11.68)	GSPASTPSTTRP..LNSVEPA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1130|    1156|       2
---------------------------------------------------------------------------
 1130- 1149 (40.30/33.00)	CICACNMNIK.GADVGLYIPD
 1160- 1180 (33.83/13.03)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     718.45|     210|     363|    1576|    1793|       3
---------------------------------------------------------------------------
  444-  622 (247.55/118.50)	SQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEEL.CMEQDPPGQKLGLAGIDSSlEVSSSRkydKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTL.SPQPRGQ............ETESLDppSV....PVNpalYGNGLELQ......QLSTLDDRTVLVGQRLPLMAevseTALYCGI.RP.................................
 1577- 1792 (341.36/187.66)	SASGSSVPPASSSASAPIISQISTTSSSGFSGSVGGQNPSTGASSSERTQGNIgCGGDTEPGQSSSQPSQDGQ.ESVTER...ERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAeEDSTSGNfwLLSLM...RCYTEMLD..NL....PEH...MRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMA....FSVYCQCrRPLPTQIHIKSLTGFGPAASIeMTLKNPER.PSPI
 2045- 2156 (129.55/58.82)	.................................................................................................NLHP..SPNS..SPVPSPG.SPSGIG...VGSHFqhsRSQGERL....LsreaPEE...LKQ....QPLALGYFVSTAKAENL..PQWFWSSC....PQAQNQC..PLFLKASLHHHISVAQTDEL.LPARNSQRvPHPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.39|      58|    1264|     156|     215|       4
---------------------------------------------------------------------------
  156-  215 (99.16/82.20)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVS.....PYG
 1423- 1487 (94.24/68.33)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSewfsqPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.11|      33|     545|     317|     362|       5
---------------------------------------------------------------------------
  317-  349 (60.77/24.78)	PSNCGMPLTPPTSPEQAIIGESGGTQNAVSHLG
  864-  894 (50.97/18.38)	PTPPSLEQHPAFSPVMNY..KDGISSETVTALG
  978- 1003 (47.37/16.03)	PKIEQLPM.PPT....ATFIRDG..YNNVPSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.06|      18|      22|    1228|    1248|       6
---------------------------------------------------------------------------
 1231- 1248 (32.44/22.14)	HTQPFASLSFLDYISSNN
 1250- 1267 (34.61/15.41)	QTLPCVSWSYDRVQADNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.19|      18|      22|    1999|    2016|       7
---------------------------------------------------------------------------
 1975- 1991 (21.38/12.16)	.TALNMQSS...QLNTPQDAS
 1999- 2016 (31.10/22.38)	PTSSTIQVA...PANYPNEDG
 2019- 2039 (26.70/17.75)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     335.76|      89|     394|     350|     440|       8
---------------------------------------------------------------------------
  350-  440 (151.71/79.26)	SQDG.GMITMHSPKRSGKIPPKlHNHM.VHRVWKECILNRTQSKRSQMSTP.TLEEEPANNLA....TWDFV......DPTQRVSCSCSRHKLlKRCAVG.PSRP
  680-  739 (65.17/26.97)	..............................KIWQD...KQPQMQPLHFLDPlPLSQQPGDSLGevndPYTFE......DGDIKYIFTAN.....KKCKQG.TEKD
  746-  841 (118.88/55.61)	SEDGfGTKDVTTPGHSTPVPEG.KNAMsLFSSTKTDVRQDNAAGRAGSSSL.TQVTDLAPSLH....DLDNIfdnsddDELGAVSPALRSSKM...PAVGtEDRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.95|      25|      25|      60|      84|       9
---------------------------------------------------------------------------
   60-   84 (48.05/27.63)	FIRCLQANLLCVWRRDVKPDCKELW
   86-  110 (47.90/27.52)	FWWGDEPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30369 with Med13 domain of Kingdom Metazoa
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