<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30362

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGSQSWGQPLRTFNGGPGRVDNVQMLGQYDQPDRPASLPQPPIRQPAIVDLTAGGPLSQDREPPPKRPRLEVPSGSNPSDTSTAVGETRSTPGSAISRPAVSWRGRPAWSFQAVVSEIPNNENRGDGTAGYKPHSPPPLPAQPWVNGFGAEPRGSGVVKSRESSPVGAVQTTPYCIEIPSVAPIYKSQKPADFAPWTGNHPEDVLSEQTTKQGYFDRTQVSQNESNTARPALYAQLKNRTGLQMLSSVFSAALEKRQSHNTIHAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKILLDQCLGKWIPVARAVWLAKCVGANEIRAFKRKGTSGTLAVGLEAKWVREWTTNVQQFVEGVFAFPKSSDWKAKMTYAIGLTARFFSENLLDHDHFLEWFLSSFETASIGTIPIWLLMLGIYWNSIMRYRRRGRRLAELLLQKVQQATEAKLIQLQPLIDRLSRFIKKLVLDHTSSMILPNSWDMYKQLVSSALDLSNEAEKALFQSLAERNARVQRPKHSKQTTQRSPHQRIVRLLDSIRTAHDLSSVFGYLDAFDDKAVLVFKLLEWLSTPFRHGLCRVYIGVRLLRKWKLAGVDIDSHILAFLSRGQNNQKLNMDQIYHVVSELVRSQTFSVGRYLQWIMARGVTNASPSAEKRKVKDLPIEIRLIAQLPVARLPEHVGNLRSTLLTRTGLSALEENAAIDSVKDIISQRLPGIFGVHEHASMALDSLPQNLPWAVKAEVGQWLRRAIGEHNWGAKSTNREMFPVGIASVVSALTPAEFYVVRDALESFGDISMLADVLKFASSCGDSTVLASVADTTNCHFDSLCVIGATTDLFRRLIDAYAGIKRFGMPSLDLIFSLIELGLRIPSELNTVSILRQDLSRMENKSIMTASSPVSDHIPDGFGGVDPFFQEKLDRLLQSGNVMDEPTLDAIFNTLIKHLESDDGHANLSANDTCRYLAQLRSFHPKHFDGILARWVCDHLRSPERTILLRILPPLIGVGCVTIRAFLTLAKKLTLSTPSTVPNAAQLPADLVQLLVSGDEDSKSIDLVSYRFQLAQQEFLNKNSEEALKIVCDAASSNANGSSTRRSELEHSITMLLRDLLVRHPECAAQNGMQKLMEQYPAALGIVQKALDLLLGIESHSDGNSVLSKVEKLACMTDDFSLPFCQLKLQVLFYAVSGSEDRTNIVDAMFKTAVSDCRARRLHWVDLVALMSPDAVRQIRERAEKAFFSIPLLEEPMGDIPDSPDKLGSLETARMYLTIIEELASSIPDSGAPFVAPVLVEKMDSLLHKIITMHNSTLAKGVANTDRSKFERALAFWFSALLRIVVLHRSAFAQPPSSLKINPLHEQLRLLTSIFCIALSRLPGDVLRLFPAADYFPHPTPTEGFRPCPGILLQTHALDVAASLIDIFPDDVRHQCARFLKEKCPSFVPFQNDSRFLYLLGPMPDQSASAQQVSAPSPAASGSTPTPTPALFSIVGSSSAQQSVAAASGLSTGPPDSNSMVSRLRLQHRGRIVGPYPVRPWELLEDAAPFLGVNDTAVNLGFFDARRVRA
Length1570
PositionKinase
OrganismPenicillium digitatum (strain PHI26 / CECT 20796) (Green mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.165
Instability index47.82
Isoelectric point8.94
Molecular weight173619.99
Publications
PubMed=23171342

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30362
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.56|      25|      26|    1239|    1264|       1
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 1239- 1264 (40.86/29.31)	IrERAEKAFFSIPLLEEPMGDIPDS..P
 1267- 1293 (37.70/21.90)	L.GSLETARMYLTIIEELASSIPDSgaP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.53|      15|      26|     128|     142|       2
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  128-  142 (29.59/21.75)	ENRGDGTAGYKPHSP
  157-  171 (26.94/18.98)	EPRGSGVVKSRESSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.11|      21|      27|    1462|    1487|       3
---------------------------------------------------------------------------
 1464- 1487 (33.95/26.36)	PD.....QSASAQQVSApspAASGSTPTP
 1489- 1514 (32.17/10.86)	PAlfsivGSSSAQQSVA...AASGLSTGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.93|      24|      27|     353|     379|       4
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  353-  376 (43.02/34.44)	GTLAVGLEAKWVREWTTNVQQFVE
  391-  414 (42.91/24.62)	MTYAIGLTARFFSENLLDHDHFLE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.68|      20|      30|      23|      52|       5
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   26-   52 (24.82/32.25)	VDnVQMLGQYDQpDRpaslpQPPIRQP
   55-   74 (38.86/14.54)	VD.LTAGGPLSQ.DR.....EPPPKRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.81|      13|      23|     709|     721|       6
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  709-  721 (21.52/13.29)	GLSALEENA..AIDS
  732-  746 (19.29/11.12)	GIFGVHEHAsmALDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.41|      16|      39|     948|     963|       7
---------------------------------------------------------------------------
  948-  963 (26.89/16.63)	LDAIFNTLI.KHLESDD
  988- 1004 (25.53/15.40)	FDGILARWVcDHLRSPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.25|      10|      21|     617|     626|       9
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  617-  626 (17.61/ 9.72)	HILAFLSRGQ
  638-  647 (16.64/ 8.80)	HVVSELVRSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.92|      14|      32|    1306|    1320|      13
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 1306- 1320 (19.41/17.99)	LLhKIITMHNSTLAK
 1341- 1354 (23.51/15.31)	LL.RIVVLHRSAFAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.42|      16|      30|     551|     566|      14
---------------------------------------------------------------------------
  551-  566 (27.01/14.07)	RLLDSIRTA..HDLSSVF
  581-  598 (26.42/13.61)	KLLEWLSTPfrHGLCRVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.68|      21|      30|    1392|    1412|      15
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 1384- 1409 (38.63/21.98)	GDV...lrlfpAA...DYFPHPTPTEGFR....PCP
 1410- 1445 (24.04/10.84)	GILlqthaldvAAsliDIFPDDVRHQCARflkeKCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.08|      25|      32|     884|     908|      16
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  884-  908 (41.72/21.42)	RIPSELNTVSILRQD.LSR.MENKSIM
  917-  943 (37.35/18.49)	HIPDGFGGVDPFFQEkLDRlLQSGNVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.21|      24|      80|      91|     127|      19
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   91-  115 (42.39/41.46)	VGETRSTPgSAISRPAVS..WRG.RPA....W
  172-  202 (31.82/ 8.54)	VGAVQTTP.YCIEIPSVApiYKSqKPAdfapW
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30362 with Med12 domain of Kingdom Fungi
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