<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30361

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADSFTLPLRPIPEKRDRPDTLPVEIAQINNQWGSFREVNEDLLRNKILEEEEKDGLNEVDESDQDATDLDSTERLEQLYKRRAEITQFAMQAHMETMFALDFVSLLLSKQAPRQAETSMSAFLKQVAPLGSLNSEVVNPPPKPESTTKDVSAVSRGWRIQNFNAAANKLLQAAFRLETEVASETRYWNEVLAVKDRGWKLSRLPREKQALGVQYGFLEATPVFRDRGLASLSRAEDGALILDEGLIPPKTRFVRVQVIQDGRLSGISKPTRSTFNSDGLIENRILQARDTVYEEELFHELVREARAIASFGVTTRQNLIQIPASDDIEILLDLVDTDEDASEHEHDISQQGTSLAEGLAHTIRILLAYAHRQNLRRRTLLPPPLTPKMRSVPEHHLIRPALAYIKHMSHVRWLQSFLNDLFGVLQSADLKPPAYTSRVFSTGRRRQTSSAPAVETLVGQFLTPLLSTFNGKILTPRGSFSIAIHTNLSSPPFGTTFDVSFNMPKYQDLESPGKLHHREEVEAAITHLLMLDVVFTISSNNSLSNSESDKDKANGTWEAIYPEHGELLIPSKSEKRKKMKIALSRHELSLEIYTVRCIDGTGRGNWEKPSHHSMSHTWKQSSIAESFKQFSLMDYVSTQVPRS
Length643
PositionHead
OrganismPenicillium digitatum (strain PHI26 / CECT 20796) (Green mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.458
Instability index49.37
Isoelectric point6.14
Molecular weight72620.28
Publications
PubMed=23171342

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30361
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.22|      30|      32|     216|     247|       1
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  216-  247 (41.69/32.55)	GFLEaTPVFRDRGLASLSRAEDGALILDeGLI
  252-  281 (48.53/28.81)	RFVR.VQVIQDGRLSGISKPTRSTFNSD.GLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.78|      16|      33|     361|     376|       2
---------------------------------------------------------------------------
  361-  376 (29.34/24.90)	HTIRILLAY.AHRQNLR
  396-  412 (26.44/21.63)	HLIRPALAYiKHMSHVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.15|      15|      39|     146|     160|       3
---------------------------------------------------------------------------
  146-  160 (28.01/20.10)	STTK...DVSAV.SRGWRI
  183-  201 (18.15/10.44)	SETRywnEVLAVkDRGWKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.21|      17|      31|      82|     101|       4
---------------------------------------------------------------------------
   82-  101 (24.71/25.07)	RRAEItqfAMQAHMETMFAL
  114-  130 (28.50/18.56)	RQAET...SMSAFLKQVAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.45|      25|      39|     440|     464|       5
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  440-  464 (43.52/27.80)	FSTGRRRQTSSAPAVETLVGQFLTP
  480-  504 (45.92/29.73)	FSIAIHTNLSSPPFGTTFDVSFNMP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30361 with Med17 domain of Kingdom Fungi
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