<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30360

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSTQVSQQPTMSATNQFPTPASSFSGNLANPTSEDVDQGRISFSMRIQDSAENSGARPSRQPTQHRPSSHDRQPLQTDSTTDFATGQGQHSTDPDAMEVDTEPTRRADTTLSLDLDSLQKELTSAFHLCKSSPIVTGPDPSLDLVSLYGLGSIAHSVARTDPVTGEKINRLRKSYEGKLKGLGLAGRNKPLKQEIGAPGSLRYMTLWPDEEWQNQKVHGKTIKVSDMDSALQSLQSRAMQMEPGLIPNNDFWEDILGHEKQAKNPAAGETGKKIAPAPTAGRPSTQFYAASPRPQEAERPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERGASYGVGMFGIGAR
Length372
PositionHead
OrganismPenicillium digitatum (strain PHI26 / CECT 20796) (Green mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.899
Instability index43.34
Isoelectric point6.77
Molecular weight40489.28
Publications
PubMed=23171342

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364141
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP30360
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.75|      23|      27|      25|      50|       1
---------------------------------------------------------------------------
   25-   50 (33.18/23.49)	SGnlANPTSEDVdQGRISFSMR..IQ.DS
   54-   79 (35.57/15.96)	SG..ARPSRQPT.QHRPSSHDRqpLQtDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.53|      25|      27|     112|     137|       2
---------------------------------------------------------------------------
  112-  137 (40.00/33.98)	SLDLDSLQKELTSAFHLCKSSPiVTG
  141-  165 (43.53/31.76)	SLDLVSLYGLGSIAHSVARTDP.VTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.70|      12|     232|      83|      95|       4
---------------------------------------------------------------------------
   83-   95 (19.23/11.63)	FAtGQGQ....HSTDPD
  315-  330 (17.47/ 6.24)	FA.GYGEgfvdDDDDPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30360 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTQVSQQPTMSATNQFPTPASSFSGNLANPTSEDVDQGRISFSMRIQDSAENSGARPSRQPTQHRPSSHDRQPLQTDSTTDFATGQGQHSTDPDAMEVDTEPTRRADTTLSLD
2) QKVHGKTIKVSDMDSALQSLQSRAMQMEPGLIPNNDFWEDILGHEKQAKNPAAGETGKKIAPAPTAGRPSTQFYAASPRPQEAERPRPSRGRKRHYDDNSFAGYGEGFVDDDDDPGFYSNGEGTGKKKRKKDHVAKVSTPMSERGASYGVGM
1
215
114
366










Molecular Recognition Features






MoRF SequenceStartStop




1) GEGFV
2) KKRKKDHVAKVS
319
341
323
352