<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30352

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGANTNIHLIDGFTNIYWRIYTEEASIANNPQESPANGYTILKHLSRLKDLEARLRGLNCLASCPRRLGLWVFSPTPEFESLNALYVRESDPESSRIVVGTTTLKVSALGSVSSLDLVKGLSSDTQSQHGTQPAGQQRPHQSQLPSRRQDGYSSSAAIYASFISAVAGSISLQIIRRHAALPLGSRTLFTAIEKSGYESPQINNESILSTSCLTTLNIQLTMSGTITVSAQTVPQTGIIRLCSPCEDTAEIIDAQPGTDLWLCPNGTIARLVTADVDSSNVLSLGYPAPGNLSAKRIQWKLDVVQWLRNFGLNVDSIDEEHWVEVEVWEPFFARLAGEAWRQSDDSQSALPLKRMLWPARFCFRRASSSNLSSEAQPSLLDEPLDFAERWSAMASSLKLDQIAHTAQNTSITQDPQSKDQEMLSPKAEPLDSIESLSRIAQYPDLQSTNLVYPTPPDGAAVVGLNNSNPPEAFTDDSDFGPPHLLQRNSRRNAPGSDISPVQNSGIGIGTGRYDASDEEDLFGEMNERDFGSKGITDADFSFFDDPDFDGMEGGSRVDDADEALEALHPQSEPEAEAMVDAEHSPNQPPGISTHVEALEVHASPIYLEAPQLSEELLAPEEPAHSPTDRAGQTISPPLSPVEVKRILFPGPEAGDHQQSTDNRGQGHYHPVVFEKKLGDWDQKYGAAGKFWFSSGGSLDALNHTSEIPTIGIPRRARSSANALGSSKELNKTSLSLIPSENGLRSASVSSDSSDESIDIISEHVPTPAAMPSMHSLKRKRASSESDIMSVASQEKSLPGTEATPGYAAENSTFLGNFLANFSDWTLTGYFSALPPQQHPVIIRREGQLEIAQLLVDQITQSSLKHPLDGKIGLFDLESEPLSLQAPDDTTLLSEASKMDFKRYISLQDEFFANQLQQHSPPPKDTPKSIISKLPAPHIRVRRGKEYLEALPPAVSFWETFGLEPAYGPKNISAYCIHPQAASKAADVFLRRFGLLYQSCSLGTHARGEDSVAFEEGLKLWKSETSSYESMMQVLKRICEQLGSELSQSPATTDNHVVYIINPFTHAAALADICSAFWYLFQQLVAGSERRQTQISNELVLQIIPLEFIMSSETMVAPPQTDYLNLALEVYSRCRPNDVDMSPLLCAPPMLLADALPRAISFRLAPERSSPLQDGRSLHIAYSKSLDQRWISVAWSDLPGSIQRTMSYCLRYRQSGGARPISEIRNEIWATTKHIMDKFQARWKVQLATTEPIETDEVEAWSSLADHHNKLNPGSLELTILAVNTIPDLILEPPVPPISMAMLNILSSSTPVSTPNASASVASPEQSGNAATPTSAGPAACTAPTPTDLSLETDSEAVLADICDDSWLAILSHRLNSSPHLTEFRPALSSGYLLRRRGAADGDGVFAITVNLIYSPRPPASYDNVLKDTLSMYRDLGCLARAKGICSVQNNTLPWHVATALRGQELLSYVF
Length1474
PositionKinase
OrganismPenicillium digitatum (strain PHI26 / CECT 20796) (Green mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.320
Instability index60.86
Isoelectric point4.96
Molecular weight161061.57
Publications
PubMed=23171342

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30352
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.01|      25|      40|     568|     605|       1
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  568-  594 (41.72/17.87)	LEAlhPQSEPEAEAMVDAEHSPNQPPG
  611-  635 (45.30/27.14)	LEA..PQLSEELLAPEEPAHSPTDRAG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.33|      31|      43|     224|     266|       2
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  226-  259 (48.77/32.39)	MSGTITVSAqtvPQTGIIRL.......CSPCE.DTAEIIDAQ
  268-  286 (15.89/17.46)	............PNGTIARL.......VTADV.DSSNVL...
 1113- 1151 (46.66/20.55)	MSSETMVAP...PQTDYLNLalevysrCRPNDvDMSPLLCAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.38|      18|      25|     521|     543|       3
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  521-  543 (20.56/22.73)	DEEDlFGEMnerDFGSKgITDAD
  548-  565 (35.82/17.50)	DDPD.FDGM...EGGSR.VDDAD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.77|      19|      25|     415|     435|       4
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  415-  435 (30.42/24.83)	ITQDPQSKDQEMLSPkaEPLD
  443-  461 (33.35/20.45)	IAQYPDLQSTNLVYP..TPPD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.69|      11|     288|    1071|    1081|       5
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 1071- 1081 (22.73/15.68)	AALADICSAFW
 1360- 1370 (22.96/15.92)	AVLADICDDSW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     304.27|      97|     883|      32|     131|       6
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   32-  131 (159.97/86.25)	ANN.PQESPANGYTILKHLSRLKDLEARL.RGLNCLASCPRRLGLW.VFSPTPEFESLN..ALYVresDPESSR...........IVVGTTTLKVSALG..SVSSLDLVKGLSSDTQS
  916- 1030 (144.30/72.03)	ANQlQQHSPPPKDTPKSIISKLPAPHIRVrRGKEYLEALPPAVSFWeTFGLEPAYGPKNisAYCI...HPQAASkaadvflrrfgLLYQSCSLGTHARGedSVAFEEGLKLWKSETSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.87|      18|      25|     347|     371|       7
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  360-  378 (30.02/14.55)	LWPARFCFRRASsSNLSSE
  740-  758 (26.84/ 6.76)	LIPSENGLRSASvSSDSSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.48|      30|     340|     135|     172|      10
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  135-  168 (45.32/41.97)	TQPAGQqrphQSQLPSRRQDGYSSSAAIYASFIS
  184-  213 (49.16/24.63)	ALPLGS....RTLFTAIEKSGYESPQINNESILS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.77|      35|     290|     481|     517|      11
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  481-  517 (62.34/44.08)	SDFGP.P......HLLQRnsRRNAPGSDISPV..QNSGI.GI.GTGRY
  765-  810 (39.43/20.95)	SEHVPtPaampsmHSLKR..KRASSESDIMSVasQEKSLpGTeATPGY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30352 with Med13 domain of Kingdom Fungi
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