<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30339

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKIMETLKKHLPVSVPEGLTELHKIAVRFEEKIYTAATSQSDYLRKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQKYLNQKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQTSAGMLLQQNNIDQKQYVQAQRGLQEAPSTSVDSTAQTGHPGIGDLQEELYQMIKSLKDQYFVELNELYNKVSIKIQQIDNQMPAQKSAEQYEKMKGFKGMLERTLHFLQVNKSNIHPGLREKIPIYERQILSILSSQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKSGMYQQLSQRNYYQQIKQGGVFPISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTPGISASPLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTTQRESLSAAVSDIGSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNFITHDGSGASKKMKRDTSAMPLNVSSAGSVNDSLKQSYGVGTPELQSTATSRVKWQRAEVNHALMEEIQEINQQLIDTELHVSEDDAESFTTSEGGKGTVIRCTFTAVAVCPSLKSVFASAQMSPILPLRLLVPASYPKCSPVLLDKFPDEQCRNSDDLSTKAKTKFSVLLRGLAEPMSLREIARTWDACARKVITEYAQQTGGGSFSSSYGCWESCVGAC
Length1308
PositionTail
OrganismZea mays (Maize)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Tripsacinae> Zea.
Aromaticity0.03
Grand average of hydropathy-0.773
Instability index70.28
Isoelectric point9.33
Molecular weight143804.39
Publications
PubMed=19965430

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30339
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.30|      24|      24|     312|     335|       1
---------------------------------------------------------------------------
  312-  335 (45.71/10.66)	QPTQ..SVVRQ.QQHPQSMHQQSSLQQ
  337-  362 (38.55/ 7.77)	QPTQqpNIPLQ.QQQPQLMNQQSNLQQ
  480-  504 (37.04/ 7.16)	QPQQ..HMMSQfQSQPNQMQQQLGMQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     412.42|      65|      65|      83|     147|       3
---------------------------------------------------------------------------
   63-  135 (92.12/27.31)	GLTEL................HKIAvrfeekiyTAATSQSD......YLRKI..SLKMLSMESQTKTQQN...P.GNVQVIPNQN..P..........PGP....APGLPPQVSNP.A
  136-  203 (76.45/21.12)	QSSAI................PLIS........QQQTRQSN......ASTSVqgSLPSLGQNSSSVSQAS...TlHNMSVMP.QNtmN..........NGL....AQG.TPQDMYA.A
  204-  274 (57.11/13.49)	QRQMA................GR..........QQQQQQQQahnqliYQQQ.....KYL...NQ.KLQQNslmP.SHIQ...QQQ..PllqstqmqssQQPmmqmSSGLQ.....P.G
  664-  710 (66.42/17.17)	QAPS...................................SN......ISQQL..Q.......TSQGLQQH...D.SHTSQMPQAS..L..........PSM....NTGVQTSGAPA.P
  810-  851 (64.24/16.31)	QS...............................QQMKQRQQ......MMQQI...............QQ.......KQTLQPQLP..I..........QQL....KKQQQQGQMQF.P
  852-  913 (56.08/13.09)	QLHSGndvnelkvrqgaaiksGMY..........QQLSQRN......YYQQI..K........QGG.............VFPISS..P..........QTL....QTS.SPQISHHsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.00|      25|      30|     711|     738|       4
---------------------------------------------------------------------------
  726-  759 (30.18/16.96)	NAPQAGSNLenaQgnnfnhvQHGSMGA.ALQQERT
  967-  987 (35.13/13.61)	SAGQAG......H.......QQTSL.APQTQSIAV
 1113- 1137 (36.68/14.59)	SAGSVNDSL...K.......QSYGVGTPELQSTAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     156.52|      38|      77|     363|     400|       5
---------------------------------------------------------------------------
  363-  396 (52.65/15.79)	...........................................NQLMN..QQSGVVETQQ.QQRLPVQ..SNNLLNMQ.QTQQ
  397-  475 (31.22/ 6.49)	MMNQqsmslhqpqqlanqgnmsslhqqqhqqnqqqqqllgtgpNARMHmlQQQKVIQQPQ.QQQHAQQ.tSMGLIQ.P.QSQQ
  525-  559 (42.41/11.35)	VQAQ.......................................RGLQE..APSTSVDSTA.QTGHP......GIGDLQeELYQ
  560-  607 (30.25/ 6.07)	MI..............................kslkdqyfvelNELYN..KVS..IKIQQiDNQMPAQksAEQYEKMK.GFKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.38|      25|     202|    1001|    1029|       9
---------------------------------------------------------------------------
 1001- 1029 (32.77/30.83)	FTSADGSPAnVP..tqVPAkSSAAERP..LDRL
 1205- 1235 (39.61/20.89)	FASAQMSPI.LPlrllVPA.SYPKCSPvlLDKF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30339 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDSAANWRSTQGTDPAAGGVDPNAAAPAGSDWRTQLQPEARHRIVNKI
2) PISSPQTLQTSSPQISHHSPQVDQHSLLQSQVKTGTPLHSANSPFVPSPSPPVAPSPMPMDSDKPLSNLSSVTSAGQAGHQQTSLAPQTQSIAVNTP
3) PLLAEFTSADGSPANVPTQVPAKSSAAERPLDRLLKALRTT
4) QKLQQNSLMPSHIQQQQPLLQSTQMQSSQQPMMQMSSGLQPGQTAIPQTQSMTMHSATQSGIQQNPLNSVQQSVQPLLHQPTQSVVRQQQHPQSMHQQSSLQQTQPTQQPNIPLQQQQPQLMNQQSNLQQNQLMNQQSGVVETQQQQRLPVQSNNLLNMQQTQQMMNQQSMSLHQPQQLANQGNMSSLHQQQHQQNQQQQQLLGTGPNARMHMLQQQKVIQQPQQQQHAQQTSMGLIQPQSQQNQLQQPQQHMMSQFQSQPNQMQQQLGMQQRLQ
5) RKISLKMLSMESQTKTQQNPGNVQVIPNQNPPGPAPGLPPQVSNPAQSSAIPLISQQQTRQSNASTSVQGSLPSLGQNSSSVSQASTLHNMSVMPQNTMNNGLAQGTPQDMYAAQRQMAGRQQQQQQQQAHNQLIYQQQ
6) SQRRKPVQAPGQQTFQQSSGQAPSSNISQQLQTSQGLQQHDSHTSQMPQASLPSMNTGVQTSGAPAPQGTNFGVPTTQQNVTNAPQAGSNLENAQGNNFNHVQHGSMGAALQQERTGPMQGALNAQQQSSSNMISNNAMSTMQTNNNANANSLQQLKQQRQEHQMMQSQQMKQRQQMMQQIQQKQTLQPQLPIQQLKKQQQQGQMQFPQLHSGNDVNELKVRQGAAIKS
1
894
996
233
90
644
48
990
1036
507
228
872










Molecular Recognition Features






MoRF SequenceStartStop




NANANA