<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30266

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPVPLEGHQTPVTNMPQEGNRGGSISLGLLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSARTRQLFVRLLALVKWASSATKVEKSAHIMAFLDKHSLLFVDTADILARMARETLVHARLPNFHLPAAVEVLTTGSYNRLPACIREKIVPPDPITLSEKRSTLQRLNQVIQHRLVTGNLMPQMKDLEIDAGRVTFRVEQEFSVSLTVMGDGPNLPWRLLDLEILVSDRETGDGKSLVHPLQTQYVHQVVQARLSESSDPLAEVYHILHYFCQSLQLEVLYSQTLRLIRDRLDDHIRIDKYISGECLTISYWKELTNKDSGSELGYKLSVLVDQHDPAKPLAIVHTPSLANKECEISDLAIRSNQLSMEYLLVHTIYIRTRNRLTDLKQELQSMFKGVECTLAGSPAILSVPILQPCLRAELLLIAVDTHTGMLQCHIPQYDAPLVPDLTAALNEDHLKLPALISELRFWITQKRCEKTLQHLPATPHEKLPLLYQPDHPITSISKHRMYVQFHRHPTVILIVSFKENELLPCEIQCSFYLCAVKASSTEQESHDDSIETKSHNIYLKLESLIEFDTFVVTHGSFTSIDCESNESESSGISETGDKSKNKRTKSPAYFIPELAHVVALCDEQIPFVMLAQELTKREIAHQGLQIEANATALVLKLVQLPAPSTNLATNSAWNALLKRLLSVAIRVQGKGTGKTWLAEFVFYGSPLISSHPKEQGLRRPIYFQYEMGTIDTIPQMVDSLLNDWAQIVNLYSLVHDLSEYYKMEKSNLRNIANIKSYNYSKLIMSYGPYRRSSVTVQWDANEKTFKLFFGKSPTSTVENAHSLLREQLEANLNRDKNLMQIIHILNETLQPLTSISKLPIIPQLGLYEKRIQIPVQTFIVMPQCISLVRIAYQSMYCLELCFRGDGLVSLRDGAYSRFDHSNVVEGFTPIQGLSTFLSQYVDKNAIYRRRSQSEDDNPPSPVTVDSEGNNGGGGPGGGGGLGGFLAHHRSGPQSPAQQREGLRFHPPHTPPSGSNPNTPASPHTANIGSQGGQHQNYGNSPGMSLNLASPPSLTPNTPNVLPHPSPGSGLVASPLNQMHAPSPAGLMPTSSPGPCSNVQLGHSPAGSFMQTGGHGVDGSPFPSSQSMASPAASNWVGSPSISRPSPVRPGQSPGHVPLHSPQQPQQQMSAEHARMGNHVSRVLPQRSWAGAIPTILTYDTLELLCSCSKHPAGVPGPDMSPLERFLGCVFMIRQLKRLIQMNERENPLSIVNSTEFGVIHFKVESLQCRVSLNPQNMQSLHIKIQPVPESGKPWTLEDLQALEKFFDSRVVAAPYKPNNLQCFINMLLMPHAVLKDFIQIMKLELIPSLVQQHQMKWAPQWCLRVPPSAMPIIPVGYPAILLKNTKILYYLHITRLGVQCREEEEPPSLILPLVYDTRNNVTLLANERDPAMAAVLVQLKRFAEYGSNSPECTLFSAVRNLLINLTLPSETVMSQQMAPNMAGAQVAPGQQIPNAGMQMMPGAQGLSQGPYRAQGIPPMNMIGGPQ
Length1539
PositionTail
OrganismNasonia vitripennis (Parasitic wasp)
KingdomMetazoa
Lineage
Aromaticity0.06
Grand average of hydropathy-0.217
Instability index56.23
Isoelectric point7.10
Molecular weight171086.75
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30266
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     474.55|     163|     354|       5|     194|       1
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    5-  194 (234.96/169.48)	PLEGHQTP.VTNMPQE....GNRGGSISLG.LLIDFIIQRTYHELTVLAELLprkTDMERKIEIyNFSARTRQLFVRLL.ALVKWASSATKVE.KSAHIMAFLDKHSLLFVdtADILARMAREtlvHARLPNF..................HLPAAvevlttgSYNRLPaCIREkivpPD.PIT.LSEKRSTLQRlnqviqHRLVTGNLMPQMKDLEI
  345-  535 (239.59/123.10)	PLAIVHTPsLANKECEisdlAIRSNQLSMEyLLVHTIYIRTRNRLTDLKQEL...QSMFKGVEC.TLAGSPAILSVPILqPCLRAELLLIAVDtHTGMLQCHIPQYDAPLV..PDLTAALNED...HLKLPALiselrfwitqkrcektlqHLPAT.......PHEKLP.LLYQ....PDhPITsISKHRMYVQF......HRHPTVILIVSFKENEL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     284.34|      36|      38|    1001|    1036|       2
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  924-  953 (30.31/10.52)	.RDGA...YSRFD...HSnvvEGF......TPIQGL..STF.LSQY
  962-  988 (36.24/14.27)	RRS.............QS...EDDNPPSPVTVDSEGN.NGG.GGP.
 1001- 1036 (72.66/37.32)	HRSGP...QSPAQ...QR...EGLRFHPPHTPPSGSNPNTP.ASPH
 1047- 1076 (42.55/18.26)	HQNYG...NSP...........GMSLNLA.SPPSLT.PNTPnVLPH
 1077- 1107 (38.25/15.55)	PSPGSglvASPLN...Q........MHAP..SPAGLMPTSS.PGP.
 1114- 1144 (35.58/13.85)	...G....HSPAGsfmQT...GG...HGVDGSPFPSS.QSM.ASPA
 1155- 1177 (28.76/ 9.54)	SRPSP...VRPGQ...SP...GHVPLHSPQQP..............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.89|      16|      20|    1407|    1426|       3
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 1407- 1422 (28.65/24.86)	TRLGVQCREEEEPPSL
 1430- 1445 (27.23/11.27)	TRNNVTLLANERDPAM
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.76|      14|      20|    1287|    1306|       4
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 1287- 1301 (21.88/23.33)	PQNMQSLhIKIQPVP
 1330- 1343 (27.88/ 9.81)	PNNLQCF.INMLLMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.55|      20|      20|     669|     688|       6
---------------------------------------------------------------------------
  669-  688 (33.22/22.33)	KLVQLPAPSTNLATNSAWNA
  692-  711 (32.33/21.51)	RLLSVAIRVQGKGTGKTWLA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.66|      17|      20|    1202|    1220|       8
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 1202- 1220 (23.08/22.31)	AGaIPTIlTYDTLELLCSC
 1225- 1241 (33.59/21.15)	AG.VPGP.DMSPLERFLGC
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.47|      23|      29|     748|     775|       9
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  751-  773 (40.17/37.52)	DSLLNDWAQI..VNLYSLVHDLSEY
  778-  802 (36.29/15.85)	KSNLRNIANIksYNYSKLIMSYGPY
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30266 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YRRRSQSEDDNPPSPVTVDSEGNNGGGGPGGGGGLGGFLAHHRSGPQSPAQQREGLRFHPPHTPPSGSNPNTPASPHTANIGSQGGQHQNYGNSPGMSLNLASPPSLTPNTPNVLPHPSPGSGLVASPLNQMHAPSPAGLMPTSSPGPCSNVQLGHSPAGSFMQTGGHGVDGSPFPSSQSMASPAASNWVGSPSISRPSPVRPGQSPGHVPLHSPQQPQQQMSAEHARMGNHVS
960
1193










Molecular Recognition Features






MoRF SequenceStartStop




NANANA