<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30255

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAMLDKRFGIDSVEKNQLQKSLDALQHSIRVTSLQSMIERLESLSRQLGLKFVMSGPPTTTNTELFISSDMFFLEVLLEPSGAVKDVKIHHDGKNEQQSEELVACLSRGDFVDFTTQLEGLASIYQLNADKKVKGKAFSALQSLETDLGILAELQKFMKEPFNVVHKSPVGILERRKGGHAMKLTYFVSPYDLIDQENKSCEALSLEAVISKKVGHSVTVCLEGSTAHKLPTSSIITVTRTPTGKSTPSYASLTSANSSMLPACFVLKLAKKMPMCLELIRKIQKVTDLECTDISVPYPLLSMIVQHTSDKQLDCQNNRGLTVSLPDQQHCYFMTENRNMEGVLVGSIPFTHPAHVPQILNVLRQQALFNTLISSCVRPMARQDSEHTTIFEVSALSWQCISVSLEHPFEETLATAELDLSDISALKCKLYGVSITNTEQTSDLAGKVLQRCLSVPLTMRTLIKAWEGRTFMLNPIGGGNNGFNSNLGTGREQNNHNGSNVPEFGNEDIIIKQEPGTGMNGTGSTGRQQQQQAPTQQQQPQQNQQQNQQQQQSFLEAGAENSIGFPSFSGSSDTPPVAMLNPLQLGALSSTPTPSGDGKSKKSRKRKAADGSWKSPKRKNDLDSNEILLESSSSDSTPLGTPTGSKDVMNDARTPTPTSAASIASAGLDLSNLDPLDVLSTDKSSDYDLDNDAEIMQVEPTVASLEEALKRERKLKKRAEEKPSPTNVFEDNKTLVSPSVSITPISSGSSSQSASYNSMLTSIGLDRRPGIEIIPIASLPQTPLLNSITITAINNPAKSSTSSSSTGTSSSSSGTSQGLGDERSKERKSSKNRSSSSSLEDKNKLEKKRKRKRESSPMGPPGKLPLKQVSSNVDPLSKPVSVSIKPASESPPSSARPSSPATTLRKFSPSPTRNNPLVLVGKSSPTSLKQSSSSSSSSGSTGGNGAGGGSGSKPVPSPKHSPVYSSPKHMSSMPSSSVSPKHGTSSPKHGNSGSAGKPSMSALKSAANSPSGKSSDGSGVSSKTKISSLQSSTSPSSSAMSLSTLSSSTSSSSSSSLSSKESRDKEARKTSSLIFGSSSGSSSGHQSPKSKSISSKPKAIDSEQQQASLSTGSGGSTPPSDPSKSALTSTQQQQQQARNRKGSLSAVIDKLKNAQHCTDDAMSSSGSNLAPSSTTGGSSSSSSASNSASKNPSDAKNPTEYMVKPSSDGMKLTINKTRTKDLKSNSSGLKLSSVALGGTSGSAGGLTITPVTMPGNILPKLFSGLKAGVISGPVSRKPQVQTSAKVRSTSPLTSSSGMGSGKSGLASGQKLSSGGLKSSSGSGLLSSSSGLAGKSLSAKSFSSTGGSSMKQSSIAAELGRARDKARFKTAGDKSFAGKGNDLRKSIPSTVESENEKALRQHLNSNILTSSMSGLSNLSGLMVEGLIKQLDTKFQIPKLSARANAADNADKRSVDKVDSGSKSSDAPGRSSQIMSNPAVSSSSNVPKLEEAHPVIAHGASNSVVGYGAGSASTSSSSANAISAHESDVPTNLSMQPDESLQMKAEVGSGRPFLNPSGESSKEGMDLAGSKHSSYSMGSDTTGNLESLNLVTKGSEKYKSSDDKDQQQQQQQHAVFHRLPHADKKSVESSITTPASITLTPIPPVSSSASAGGSGTSSQEAAEMLLDFSTPKESGGGGGSVSSLPLKSAMSFAASSSSPIRKNTTPPPPPPPPPLPPPPPPSVSPAVLAAVPPSVSPISSFPQSPSVSLHIVKSPAPSPRVIPLSPHSASPCITDDELMDEAIALETAKLQSTTAVRYDSLSWKKP
Length1804
PositionMiddle
OrganismNasonia vitripennis (Parasitic wasp)
KingdomMetazoa
Lineage
Aromaticity0.03
Grand average of hydropathy-0.517
Instability index58.55
Isoelectric point9.34
Molecular weight188608.66
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30255
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     750.47|      96|     119|     885|    1003|       2
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  636-  748 (68.61/12.13)	STP...........................L........GTPTGSKDV..M.......................NDARTPTPTSAASiASAGL.DLS.N..........LdpldvlstdkssdydldndaeimqvEPTVASLE...................EA..LKRERKL..KKRAEEKPSPTNvfedNKTLV.............SPSVSITPISS...G
  749-  810 (63.26/10.64)	SSSQS..ASYNS..................M........LTSIG........................................................................................ldrRPGIEIIP...................IA..SLPQTP....LLNSITITAI.....NNP....AKS........S.TSSSSTGTS...S
  811-  871 (60.92/ 9.99)	SSSGT..SQG.............................LGDERS.....................................KERKS.SKNRSSSSSlE..........D.........................KNKLEKKR...................KR..KRESSPM..........GPPG....KLPL...................KQVSS.....
  872-  935 (84.69/16.60)	.....................................................................................NV.DPLSKPVSV.S..........I.........................KPASESPP...................SS..ARPSSPA..TTLRKFSPSPTR....NNPLVLVGKS........SPTSLKQSSSS...S
  936- 1056 (104.19/22.02)	SSSGS..TGGNG..................A........GGGSGSKPV..PspkhspvysspkhmssmpsssvsPKHGTSSPKHGNS.GSAGKPSMS.A..........L.........................KSAANSPSgkssdgsgvssktkisslqSS..TSPSSSA..MSLSTL...................S........SSTS..SSSSS...S
 1057- 1162 (87.89/17.49)	LSSKE..SRDKE..................ArktsslifGSSSGSSS..............................GHQSPKSKSI.SSKPKAIDS.E..........Q..................qqaslstGSGGSTPP...................SD..PSKSALT..STQQQQQQARNR....KGSLSAVIDK........LKNAQHCTDDA...M
 1163- 1233 (75.41/14.02)	SSSGSnlAPSST..................T........GGSSSSSS......................................AS.NSASK..........................................NPSDAKNP...................TEymVKPSSDGmkLTINK.....TR....TKD..L..KS........NSSGLKL...S...S
 1234- 1326 (80.85/15.53)	VALG....GTSG..................S........AGGLTITPVtmP.....................................GNILPKLFS.G..........L.........................KAGVISGP...................VS..RKPQV.Q..TSAKVRSTSPLT....SSSGMGSGKSglasgqklSSGGLKSSSGSgllS
 1327- 1405 (72.81/13.29)	SSSGL..AGKSL..................S........A...................................KSFSST...GGS..SMKQSSIA.AelgrardkarF.........................KTAGDK.....................SF..A...GKG..NDLRKSIPST............VESE........NEKALRQHLNS...N
 1644- 1723 (51.84/ 7.46)	SSSAS..AGGSGtssqeaaemlldfstpkeS........GGGGGS..V..S..............slplksamsFAASSSSPIRKNT.TPPPPPPPP.P..........L.........................PP...PPP...................PS..VSP.......................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     447.71|     151|    1076|     396|     577|       3
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  396-  577 (229.59/172.25)	LSWQCISVSLEHP.FEETLATAELDLSDiSALKcklYGVSITNTEQTSdlAGKVLQRCLSVP..LTMR...TL.IKA..WEGRTFmLNPIGggnngfnsnlGTGREQNNHNGSNVPEFgnediiikqepgtGMnGTGSTGRQQQQQAPTQ.....QQQPQQNQQQNQQQQQSFL......EAGAENSIGFPSFSGSSDTPPV
 1473- 1643 (218.12/111.11)	MSNPAVSSSSNVPkLEEAHPVIAHGASN.SVVG...YGAGSASTSSSS..ANAISAHESDVPtnLSMQpdeSLqMKAevGSGRPF.LNPSG..........ESSKEGMDLAGSKHSSY.............SM.GSDTTGNLESLNLVTKgsekyKSSDDKDQQQQQQQHAVFHrlphadKKSVESSITTPASITLTPIPPV
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.01|      15|      15|    1432|    1446|       4
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 1432- 1446 (23.76/13.05)	KFQIPKLSARANAAD
 1450- 1464 (23.25/12.58)	KRSVDKVDSGSKSSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.63|      17|      19|     168|     184|       5
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  168-  184 (29.62/19.69)	SPVGILERR.KGGHAMKL
  189-  206 (25.01/15.33)	SPYDLIDQEnKSCEALSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.30|      13|      21|    1731|    1744|       6
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 1731- 1743 (25.67/11.84)	PSVSPISSFPQSP
 1757- 1769 (25.63/ 7.36)	PRVIPLSPHSASP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.99|      11|      16|     310|     321|       8
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  310-  321 (17.33/14.61)	DKQlDC...QNNRGL
  327-  340 (17.65/ 9.46)	DQQ.HCyfmTENRNM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30255 with Med1 domain of Kingdom Metazoa
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