Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MKEAELRPVNSEQLIKLAHLISKHNSVAAPLTWQIGDPSRPFPQEHEFRSGHLLNPKIQSTGPQLVPGKNASQKVAQVSIGTFGNLEY |
Length | 88 |
Position | Middle |
Organism | Caenorhabditis japonica |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida> Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae> Caenorhabditis. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.492 |
Instability index | 46.55 |
Isoelectric point | 9.22 |
Molecular weight | 9708.94 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP30225 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 83.59| 24| 31| 7| 30| 1 --------------------------------------------------------------------------- 7- 30 (39.26/25.03) RPVNSEQLIKLAHLISKHNSVAAP 40- 63 (44.32/29.00) RPFPQEHEFRSGHLLNPKIQSTGP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MKEAELRPVNSEQLIKLAHLISKHNSVAAPLTWQIGDPSRPFPQEHEFRSGHLLNPKIQSTGPQLVP 2) VAQVSIGTFGNLEY | 1 75 | 67 88 |
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