<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30219

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISENKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGPTVGPLPHDVEVAIWQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDHNSSVIFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKLEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVRQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGSGRSGPYGVTVPPDLLHHPNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTSMIGTMTPLGAQSVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRVRPWDVIWDLGARGGGEGAAAATQAPPEVHKIERGSICVLSHQQGRAAGLKLGLKIPILPPFPEGSGRRELGVVCWVLQVWFSLQLSEWGEQQTQSSCPVFLPLSPSLHH
Length2187
PositionKinase
OrganismSus scrofa (Pig)
KingdomMetazoa
Lineage
Aromaticity0.07
Grand average of hydropathy-0.434
Instability index54.26
Isoelectric point6.68
Molecular weight243288.74
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30219
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.90|      16|      16|    2037|    2052|       1
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 2037- 2052 (34.75/18.39)	QQQQQQQQQQQ....QQQQQ
 2054- 2073 (29.15/14.19)	QQQQQQQQQQQyhirQQQQQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     430.94|     137|     148|     920|    1067|       2
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  912- 1062 (219.82/153.06)	AVLRHyhaCLILNQDQMAqVFEGLCGVVKHGM.NRSD.GSSAERCILAYLYDLYTSCSHLKSKFGELFSDF..CSKVKNTI..YCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGlgkslsENPANRYSFVCNalMHVCVGHHdpDRVNDIAILC
 1063- 1206 (211.12/122.91)	AELTG..yCKSLSAEWLG.VLKALCCSSNNGTcGFNDlLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLirCAAIPSLLnaACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDG......NKPTVGIRSSCD..RHLLAASQ..NRIVDGAVFA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.57|      18|      19|    1718|    1735|       3
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  683-  699 (27.27/ 9.84)	PDFSLFSP....TMPCEGKGS
 1718- 1735 (33.49/13.82)	PRAYYLEP...LPLPPEDEEP
 1736- 1756 (28.80/10.82)	PAPTLLEPekkAPEPPKTDKP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.31|      17|      20|    1941|    1958|       4
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 1941- 1957 (34.44/14.49)	QHTGPA..GTMVPPSYSSQ
 1960- 1978 (26.88/11.06)	QSTHPStnPTLVDPTRHLQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     234.71|      57|     125|    1474|    1531|       5
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 1474- 1531 (89.03/66.01)	KGQDEQREGLLTSLYSQVRQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGmFDTV
 1553- 1601 (63.67/40.73)	TVDMQSNNELFTTVLDMLSVLINGTLAADM..SSISQGSMEENKRAYMNLV.......
 1603- 1655 (82.02/55.35)	KLQKELGERQSDSL.EKVRQLLPLPKQTRDVITCEPQGSL...IDTKGNKIAG.FDSI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     287.82|      56|     104|    1877|    1932|       6
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 1766- 1821 (48.58/20.90)	.....RKKKST..KGKK.RSQPATK.TEDYGMgsgrsgpygvtVPPDLLHHPNPGSISHLSY...RQG...
 1824- 1874 (76.89/37.78)	..GLYTQNQPLPAGGPRVDPYRPVR.LPMQKL...........PTRPPYPGVLPTTMTGV......MGLEP
 1877- 1932 (92.85/47.30)	KTSVYRQQQPAVPQGQRLRQQLQAK.IQSQGM...........LGQSSVHQMTPSSSYGLQT...SQGYTP
 1981- 2035 (69.51/33.38)	PSGYVHQQAPTYGHGLTSTQRFSHQtLQQTSM...........IG.....TMTPLGAQSVQAgvrSASILP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.96|      50|     246|     329|     396|       7
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  341-  396 (79.55/87.01)	STPSTP.FSD.............................LLMCPQHRPLVFGLSciLQTILLCCPSALVwhYSLTDSRikTGSPLD
  560-  639 (77.41/40.39)	SAPSAPiFQDvllqfldtqapmltdprseserveffnlvLLFCELIRHDVFSHN..MYTCTLISRGDLA..FGAPGPR..PPSPFD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.09|      26|     200|    1223|    1250|      18
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 1223- 1250 (42.89/27.72)	GFTVTGGTEELpeEEGGG.GSGGRRQGGR
 1425- 1451 (41.20/20.42)	GHVLKAAGEEL..EKGQHlGSSSRKERDR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30219 with Med12 domain of Kingdom Metazoa
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