<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30216

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYVCEWEKRPKSNHCPSIPLVCAWSCRNLIAFTTDLKNEEEKGIDLTHMIHILDTEHPWDVYSINSGHIEIITCLEWDQSGIGSRLLSADADGHIKCWSMTDHLANSWENTVGSMVEGDPIVALSWLHNGVKLALHVEKVQSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTSTESLCRLRCRVALADIAFTGGGNIVVATSDGSSTSPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVKVLLCASNQNSSIVECWSLRKEGLPVNNIFQQISPVGEVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGTGLALAFHDGSVHIVHRLSLQTMAVFYGSSSQRPVDEQAIKRQRAAGPLVHFKAMQLSWTSLALVGIDNHGKVQLSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPSMVQNLVEKLHEEYMRQNAALQQVQVLSTRIVAMKASLCKLSSSTVARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEICSKITDIGTDIDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFVLYLLASLPNQVQGSPVRPGHSFLRDGASLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCKGLKLPRIPATRPLWVQGTLLAGCRKPPQGQRGSG
Length744
PositionTail
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.07
Grand average of hydropathy0.054
Instability index39.49
Isoelectric point8.44
Molecular weight82554.26
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30216
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.36|      19|      99|     326|     361|       1
---------------------------------------------------------------------------
  343-  361 (31.31/ 9.84)	ATNDLDRVSAVALPKLPIS
  443-  461 (32.05/27.54)	ALVGIDNHGKVQLSMLRIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.45|      20|     523|     119|     138|       7
---------------------------------------------------------------------------
  119-  138 (35.53/23.22)	VEGDPI.VALSWLHNGVKLAL
  643-  663 (32.93/20.96)	VQGSPVrPGHSFLRDGASLGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.87|      26|     202|      78|     103|       8
---------------------------------------------------------------------------
   78-  103 (49.21/28.47)	LEWDQSGIGSRLLSADADGH..IKCWSM
  281-  308 (41.66/23.12)	LARDMSEQVKVLLCASNQNSsiVECWSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30216 with Med16 domain of Kingdom Metazoa
Unable to open file!