<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30210

Description Cyclin dependent kinase 19
SequenceMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAMHIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKGDKPRLSQNFNKQDVPCSPSQQTSLPPATSASQPTSTQTNGTAGGGGTGGGGTGAGLQHSQDSSLNQVPPNKKPRIGPSGTNSGGPVMPTDYQHSSSRLSYQSNIQGSSQTQSTMGYSTSSQQSSQYHQSHQSHRY
Length443
PositionKinase
OrganismPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Trionychia> Trionychidae> Pelodiscus.
Aromaticity0.09
Grand average of hydropathy-0.636
Instability index60.00
Isoelectric point8.96
Molecular weight50039.14
Publications
PubMed=17381049
PubMed=23624526

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30210
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.03|      30|      32|     351|     380|       1
---------------------------------------------------------------------------
  327-  366 (47.40/22.71)	SQQTSLPPATSASQptstqtngtaGGGGTGGGGT..GAGLQH
  367-  401 (48.63/23.46)	SQDSSLNQVPPNKK.......priGPSGTNSGGPvmPTDYQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.27|      22|      28|     271|     292|       2
---------------------------------------------------------------------------
  271-  292 (41.46/23.63)	QDPYFQEDPLPTSDVFAGCQIP
  302-  323 (38.81/21.70)	DEPEEKGDKPRLSQNFNKQDVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      37|      91|     105|       3
---------------------------------------------------------------------------
   91-  105 (26.77/16.48)	DLKPANILVMGEGPE
  129-  143 (28.67/18.09)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.13|      15|      27|     179|     193|       4
---------------------------------------------------------------------------
  179-  193 (27.73/18.16)	EDIKTSNPFHHDQLD
  208-  222 (27.39/17.85)	EDIRKMPEYPTLQKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30210 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKGDKPRLSQNFNKQDVPCSPSQQTSLPPATSASQPTSTQTNGTAGGGGTGGGGTGAGLQHSQDSSLNQVPPNKKPRIGPSGTNSGGPVMPTDYQHSSSRLSYQSNIQGSSQTQSTMGYSTSSQQSSQYHQSHQSHRY
291
443










Molecular Recognition Features






MoRF SequenceStartStop




1) GPVMPT
2) QYHQSHQSHRY
3) RLSYQSNIQGS
4) SLNQVPPNKKPRIGPS
5) STMGYSTSS
392
433
405
371
420
397
443
415
386
428